Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"P4HB"”.
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P4HB TARGETING HALTS TUMOR GROWTH AND RE-SENSITIZES RESISTANT MELANOMA CELLS TO DABRAFENIB AND TRAMETINIB STANDARD-OF-CARE THERAPY VIA IRE1-⍺ ACTIVATION AND AKT DOWNMODULATION
… (CREBBP) and Prolyl 4-Hydroxylase Subunit Beta (P4HB), whose inhibition reduced tumor growth in vivo and increased overall survival of A375-DT but not of A375 parental cells, suggesting a putative point of intervention in resistant tumors. Additionally, I demonstrated that silencing CREBBP and …
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Reprogramming of human PBMCs into iPSCs for the In-vitro manufacture of engineered vascular grafts based on biodegradable synthetic polymers
… seeded on either PGApoly- 4-hydroxybutyrate (P4HB), PGA-poly-lactic acid (PLA) or PGA-poly–caprolactone (PCL) patches. Later, these patches were analyzed qualitatively and quantitatively. We found that PGA-P4HB and PGA-PLA scaffolds enhance tissue formation significantly higher than PGA-PCL …
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A Novel Media-Concentration Based Accelerated Hydrolytic Degradation Model for Biodegradable Polymers Based on Time-Concentration Superposition Frameworks
… (PLGA) anchors and a poly(4-hydroxybutyrate) (P4HB) suture, designed to percutaneously secure the fetal membrane during surgery and safely degrade postnatally. Understanding and predicting the degradation behavior of bioresorbable polymers is essential for medical device development. In this …