Global ETD Search

P4HB TARGETING HALTS TUMOR GROWTH AND RE-SENSITIZES RESISTANT MELANOMA CELLS TO DABRAFENIB AND TRAMETINIB STANDARD-OF-CARE THERAPY VIA IRE1-⍺ ACTIVATION AND AKT DOWNMODULATION

ZOCCHI, ANGELICAUniversità degli Studi di Milano2025

… (CREBBP) and Prolyl 4-Hydroxylase Subunit Beta (P4HB), whose inhibition reduced tumor growth in vivo and increased overall survival of A375-DT but not of A375 parental cells, suggesting a putative point of intervention in resistant tumors. Additionally, I demonstrated that silencing CREBBP and …

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