Global ETD Search
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Showing 1 to 3 of 3 for “"P2Y12 inhibitors"”.
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Genotype- versus phenotype-directed personalization of antiplatelet treatment in Koreans with coronary artery disease undergoing coronary stenting
… phenotype-directed individualization for use of P2Y12 inhibitors to decrease high on-treatment of platelet reactivity (HOPR). Sixty-five patients undergoing percutaneous coronary intervention for non-ST elevation acute coronary syndromes were randomly assigned to genotype- or phenotype-directed …
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Novel Agonists and Antagonists of Platelet Receptors
… ADP-activated G-protein coupled receptor (GPCR) P2Y12 is a key receptor for platelet activation, and thus for thrombus formation, which makes P2Y12 a target in pharmaceutical antiplatelet therapies. As a complement during revascularization surgery, mild hypothermia has been accepted, but its …
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Investigating small-molecule inhibitors of platelet aggregation
… by the Gi-protein-coupled receptor (GPCR), P2Y12. Therefore, P2Y12 antagonists are clinically used to prevent thrombotic events. However, current antiplatelet drugs have several drawbacks such as the increased risk of bleeding, difficulty in fine-tuning the antiplatelet effects of …