Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"P2Y12"”.
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Biochemische Charakterisierung des ADP-Rezeptors P2Y12 und pharmakologische Therapiekontrolle von Thrombozytenfunktionshemmern
… die Phospholipase D als ein neuer Effektor des P2Y12 nachgewiesen werden, deren Stimulierung wahrscheinlich zur Degranulierung von Thrombozyten führt. Dieser Mechanismus könnte der Entscheidende sein, der der essentiellen Rolle des Gi-Proteins bei der Stimulation der Sekretion und der …
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Role of P2Y12 receptor-mediated ADP signalling at microglia in the phagocytosis of neurons
… this loss. The ADP-specific microglial receptor P2Y12 has been implicated in long-range communication between neurons and microglia, as well as in microglia chemotaxis preceding phagocytosis, but the direct role of this receptor in phagocytosis of live neurons has not been addressed. In addition, …
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Novel Agonists and Antagonists of Platelet Receptors
… ADP-activated G-protein coupled receptor (GPCR) P2Y12 is a key receptor for platelet activation, and thus for thrombus formation, which makes P2Y12 a target in pharmaceutical antiplatelet therapies. As a complement during revascularization surgery, mild hypothermia has been accepted, but its …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… to airway inflammation by interacting with P2Y12 receptor as well as type 1 and 2 cysteinyl leukotriene receptors. We investigated the effects of P113, a P2Y12 receptor antagonist, on airway inflammation in a mouse model of allergic asthma. MATERIALS AND METHODS: Sensitized BALB/c mice were …
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Study of patients with suspected platelet-based bleeding disorders: a search for patients with a defect in the P2Y12 ADP receptor
… inherited gene defects in the ADP P2Y12 receptor and only one in the platelet TxA2 receptor have been reported, with none in the UK. Over a period of nearly 4 years, patients with a diagnosis of platelet dysfunction made at UK Comprehensive Haemophilia Care Centres were investigated …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… on the other hand antagonizes ADP receptor P2Y12. ADP is a weak platelet agonist stored in platelet dense granules and is released upon platelet activation. ADP activates platelets through two purinergic receptors namely P2Y1 and P2Y12 these receptors couple to Gq and Gi class of G-proteins, …
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Investigating small-molecule inhibitors of platelet aggregation
… by the Gi-protein-coupled receptor (GPCR), P2Y12. Therefore, P2Y12 antagonists are clinically used to prevent thrombotic events. However, current antiplatelet drugs have several drawbacks such as the increased risk of bleeding, difficulty in fine-tuning the antiplatelet effects of …
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Genotype- versus phenotype-directed personalization of antiplatelet treatment in Koreans with coronary artery disease undergoing coronary stenting
… phenotype-directed individualization for use of P2Y12 inhibitors to decrease high on-treatment of platelet reactivity (HOPR). Sixty-five patients undergoing percutaneous coronary intervention for non-ST elevation acute coronary syndromes were randomly assigned to genotype- or phenotype-directed …
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H θέση της τικαγκρελόρης ως αντιαιμοπεταλιακό φάρμακο
… από του στόματος αναστολέας του υποδοχέα P2Y12, ο οποίος έχει καθιερωθεί ως βασικό αντιαιμοπεταλιακό φάρμακο στην αντιμετώπιση των οξέων στεφανιαίων συνδρόμων και στη δευτερογενή πρόληψη καρδιαγγειακών επεισοδίων. Σκοπός της παρούσας διπλωματικής εργασίας είναι η συνολική αξιολόγηση του …
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DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort
Background: P2Y12 receptor is the target for thienopyridine mediated platelet inhibition. Epigenetic factors, including DNA methylation could influence gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA …
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Downstream Cangrelor versus upstream ticagrelor in patients with St-Segment elevation myocardial infarction
… Il pretrattamento con un inibitore del recettore P2Y12 può essere preso in considerazione nei pazienti con infarto miocardico con sopraslivellamento del tratto ST (STEMI) indirizzati ad una rivascolarizzazione miocardica percutanea (PCI). In questo contesto, dove l’assorbimento orale può essere …
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Molecular genetic mechanisms of eosinophil activation in aspirin-exacerbated respiratory disease : Genetic mechanisms of eosinophil activation
… both cells could express purinergic receptor P2Y12. Considering that elevated eosinophil infiltration constitutes a major characteristic feature of asthma and AERD, we hypothesize that activation of eosinophils via dysregulation of IL5, IL5RA and P2RY12 genes may play an important role in the …
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Adiponectin : a novel circulating anti-thrombotic factor in humans?
… synergy was found to occur via the Gi-coupled P2Y12 receptor and not Gq-coupled P2Y1. Since the secretion of ADP from platelet dense-granules is driven by protein kinase C (PKC), we examined the role of PKC in gAd-mediated platelet aggregation. Ablation of PKC using a general inhibitor reduced …
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Aspects of bleeding complications and hemostasis at central line insertion and mild induced hypothermia
… and aspirin, this effect was offset by powerful P2Y12 blockade, confirmed by analysis of vasodilator-stimulated phosphoprotein. The effect of ticagrelor was delayed in survivors of cardiac arrest, probably due to slow gastric emptying. Paper IV demonstrated prolonged clot initiation and decreased …
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Investigating the role of the CCL2/CCR2 axis in monocytes and its modulation by extracellular nucleotides
… that although P1, P2X1, P2X4, P2X7, P2Y1, P2Y11, P2Y12, and P2Y13 purinoceptors were unlikely to play a major role, P2Y6 and CCR2 engaged in crosstalk. Cross-desensitisation experiments and studies on P2RY6-knockdown THP-1 cells supported this finding and indicated that a blockade of P2Y6 …
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Πρωτόκολλο μελέτης προσδιορισμού της αντιδραστικότητας των αιμοπεταλίων με τη συσκευή μέτρησης VerifyNow σε ασθενείς υπό αιμοκάθαρση : σύγκριση της διπλής δόσης κλοπιδογρέλης (150mg) έναντι πρασουγρέλης (10mg)
… των αιμοπεταλίων καθορίστηκε η τιμή PRU (P2Y12 reaction units) ≥235. Επίσης μελετήθηκε η παρουσία του CYP2C19*2 loss-of-function αλληλίου ως πιθανού παράγοντα που σχετίζεται με την αντιδραστικότητα των αιμοπεταλίων. Αποτελέσματα: Το πρωτεύον καταληκτικό σημείο της αντιδραστικότητας των …
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The Molecular Mechanism of Platelet Activation in Inflammation
… activation by targeting thromboxane A2 and P2Y12 receptor-mediated pathways, respectively. These findings suggest that histones directly disrupt the platelet membranes, which is followed by the release of agonists that engage multiple receptors on the platelet surface. This necessitates …
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Non-invasive tuning of experience-dependent plasticity in the primary visual cortex
… and that interfering with microglial purinergic P2Y12 receptor activation blocks the ketamine-induced enhancement of ODP. Building on these insights, Chapter 3 investigates the use of non-invasive light-flicker stimulation at different temporal frequencies as a means to unlock different forms of …
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Synthesis and biological evaluation of purine and pyrimidine based ligands for the A3 and P2Y2 purinergic receptors
… in 8 subtypes: P2Y1, P2Y2,P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, P2Y14. In the first part of this work (chapter 2 and 3), we present the synthesis and biological evalutation of two series of adenosine A3 receptor ligands. In the second part (chapter 4), we discuss the synthesis and biological …
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