Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"P2Y Receptor"”.
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The role of the microglial P2Y₆ receptor in ageing, development, and tauopathy
… has shown that activation of the microglial P2Y₆ receptor (P2Y₆R) with uridine diphosphate (UDP) induces microglial phagocytosis. Also, young mice with knockout of the P2Y₆R gene (*P2ry6⁻´⁻*) were found to perform worse in memory tests compared to *P2ry6⁺´⁺* mice, but *P2ry6⁻´⁻* mice were …
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PURINERGIC TRANSMISSION IN MIGRAINE: ROLE OF P2Y RECEPTORS IN THE SPINAL-TRIGEMINAL SYSTEM IN VIVO AND IN VITRO
… functionality, and cellular localization of P2 receptors in primary mixed neuron-glia cultures prepared from mouse TG. Our results show that TG sensory neurons mainly express functional P2X3 receptors, while SGCs are highly responsive to P2Y-agonists (i.e., ADP, UTP, and UDP). Moreover, exposure …
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Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells
In light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic the third extracellular loop of the human P2Y2 receptor, the aim of this study was to use this peptide as an immunogen to generate and fully characterise polyclonal rabbit …
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Extracellular Nucleotides Induce Transient Elevation of Cytosolic Calcium in Articular Chondrocytes
… that can regulate cell behavior by binding to P2Y receptors. Our objective was to test the effect of nucleotides on P2Y receptor activity in live articular chondrocytes by monitoring changes in the concentration of cytosolic free calcium. ATP and UTP induced large transient elevations of …
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Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation
… brain, however it is now known that they have receptors that bind neurotransmitters released into the synapse, and in turn, can cause the release of gliotransmitters from the astrocyte (Araque, 2008; Araque et al., 1999; Parpura & Zorec, 2010; Perea et al., 2009). The most commonly released …
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Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system
… excitation, and activates both ion channel receptors (P2X) and G protein-coupled receptors (P2Y) on post-synaptic cells. In addition to its role as a neurotransmitter, ATP and other nucleotides are known to be released from injured or ischemic tissue and have been reported to affect …
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ADP regulation of insulin secretion and beta-cell apoptosis
… via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… Clopidogrel on the other hand antagonizes ADP receptor P2Y12. ADP is a weak platelet agonist stored in platelet dense granules and is released upon platelet activation. ADP activates platelets through two purinergic receptors namely P2Y1 and P2Y12 these receptors couple to Gq and Gi class of …