Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"P2Y RECEPTORS"”.
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THE ROLE OF P2Y RECEPTORS IN HUMAN VASCULAR SMOOTH MUSCLE
… were ineffective, ruling out the involvement of P2Yi, P2Yi2, P2Yi3 and P2Yii receptors respectively. This suggests that the proproliferative action of ATP is at P2Y2 receptors, whilst the anti-proliferative action is at P2Y4 (UTP) and P2Y6 (UDP) receptors. In SV cells, the marked downregulation …
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Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells
… mimic the third extracellular loop of the human P2Y2 receptor, the aim of this study was to use this peptide as an immunogen to generate and fully characterise polyclonal rabbit antibodies to the P2Y2 receptor. Other aims of this study were to characterise epithelial and endothelial cells for a …
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PURINERGIC TRANSMISSION IN MIGRAINE: ROLE OF P2Y RECEPTORS IN THE SPINAL-TRIGEMINAL SYSTEM IN VIVO AND IN VITRO
… functionality, and cellular localization of P2 receptors in primary mixed neuron-glia cultures prepared from mouse TG. Our results show that TG sensory neurons mainly express functional P2X3 receptors, while SGCs are highly responsive to P2Y-agonists (i.e., ADP, UTP, and UDP). Moreover, exposure …
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Extracellular Nucleotides Induce Transient Elevation of Cytosolic Calcium in Articular Chondrocytes
… that can regulate cell behavior by binding to P2Y receptors. Our objective was to test the effect of nucleotides on P2Y receptor activity in live articular chondrocytes by monitoring changes in the concentration of cytosolic free calcium. ATP and UTP induced large transient elevations of …
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Synthesis and biological evaluation of purine and pyrimidine based ligands for the A3 and P2Y2 purinergic receptors
P1-receptors, or adenosine receptors, and P2Y receptors, are G-protein-coupled receptors, belonging to the purinergic receptor family. Adenosine is the natural ligand of the P1 receptors, while P2Y receptors are activated by nucleotide ligands (ATP,ADP, UTP and UDP). The adenosine receptors (P1) …
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Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation
… brain, however it is now known that they have receptors that bind neurotransmitters released into the synapse, and in turn, can cause the release of gliotransmitters from the astrocyte (Araque, 2008; Araque et al., 1999; Parpura & Zorec, 2010; Perea et al., 2009). The most commonly released …
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Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha
… release of extracellular nucleotides acting on P2Y receptors, leading to increased [Ca2+]i and subsequent activation of calcineurin and NFATc3. It also decreases the export of NFATc3 from the nucleus by inhibition of GSK-3beta and JNK activity. Arteries of diabetic patients display increased …
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Mitogene Effekte extrazellulärer Nukleotide in humanen Mesangialzellen
… Charakterisierung scheinen verschiedene P2Y-Rezeptoren an den Wachstumsvorgängen beteiligt zu sein: P2Y1-, P2Y2-, P2Y4- und P2Y11-Rezeptor. Die Bindung an Purinrezeptoren aktiviert im weiteren Verlauf die MAP42/44 Kinase Kaskade. Es konnte kein Hinweis gefunden werden, dass ATP auch über …