Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"P2X7R"”.
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THE ROLE OF P2X7R IN METHAMPHETAMINE-INDUCED BEHAVIORAL CHANGES AND MICROGLIAL EFFECTOR FUNCTIONS
… and neurodegenerative processes. In particular, P2X7R is activated by pathological concentrations of ATP. I show the concurrent increases in P2X7R expression with Iba-1, a marker of microglial activation after chronic METH treatment in vivo. I confirmed the METH-induced increases in P2X7R protein …
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Roles of the P2X7 receptor in C6 astroglioma: in vitro and in vivo studies
The purinergic P2X7 receptor (P2X7R) is an ionotropic adenosine triphosphate(ATP) receptor which is closely linked with pathological conditions in the central nervous system (CNS). Gliomas are the most common primary brain tumors with presently no cures. The roles of the P2X7R in these diseases …
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New purinergic-based pharmacological targets for the treatment of retinal disorders
… pathway, which includes the P2X7 receptor (P2X7R). This ATP-gated ion channel has been linked to vascular inflammation due to an over-expression of cytokines, contributing to BRB alteration. The integrity of this physical barrier is essential for a proper vision; indeed, the BRB dysfunction …
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The physiological role of P2X4 receptors in lysosome function
… fusion. The first candidate I investigated was P2X7R, which is typically co-expressed with P2X4R in immune and epithelial cells, and which has already been shown to induce changes in lysosome properties upon activation. I co-expressed these two receptors in normal rat kidney (NRK) cells and in …
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P2XR7 y Panexina 1 en el cuerpo carotideo humano. Contribución al conocimiento de la Neurotrasmisión purinérgica
… y distribución del receptor purinérgico P2X7R en el cuerpo carotídeo humano; 2) estudiar la expresión del canal de membrana panexina 1, funcionalmente asociado a P2X7R; y 3) evaluar la expresión de ambas proteínas en el ganglio petroso y en el ganglio simpático cervical superior.
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Increased Microglial Reactivity Alters Morphine Analgesia
… morphine causes a potentiation in microglial P2X7R function mediated by µ-receptor activation of Src kinase. Specifically, I identified tyrosine residues 382-384 on the P2X7R C-terminal domain as a critical site of phosphorylation and found that interfering with this site attenuated the …
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Neuromodulation by endogenous Interlukin-1β in hippocampus of the murine brain: Regulation of neuronal excitation
<p>The pro-inflammatory cytokine, Interleukin-1β (IL-1β), is well known for its ability to initiate and propagate inflammatory responses at sites of infection and tissue injury. Paradoxically at odds with this classic view, it is now clear that IL-1β signaling modulates a number of physiological …