Global ETD Search
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Showing 1 to 5 of 5 for “"P2X4"”.
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The physiological role of P2X4 receptors in lysosome function
P2X4 receptors (P2X4R) are ligand-gated ion channels activated by ATP and with a high permeability to Ca2+. They are predominantly localised to lysosomes and from there can traffic to the cell surface. ATP levels within the lysosome are high but P2X4Rs are inhibited by the acidic pH. Previously, it …
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Recettori purinergici ionotropi e i loro ruoli nella neuroinfiammazione mediata dalla microglia
… entrambi i recettori ionotropici purinergici P2X4 e P2X7. Quest'ultimo è stato ampiamente studiato come attore principale nella risposta infiammatoria mediata dalla microglia. Tuttavia, poiché i livelli extracellulari di glutammato sono aumentati in modo simile nella neuroinfiammazione e il …
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Einfluß von extrazellulären Nukleotiden auf den eosinophilen Granulozyten
… spezifischer mRNA der Subtypen P2X1, P2X4, P2X7, P2Y2, P2Y4, P2Y5, P2Y7 und P2Y11 erbracht werden. <br>Weiter konnte gezeigt werden, daß ATP, UTP und BzATP konzentrationsabhängig eine Mobilisation von Kalzium in Eosinophilen verursachen. Die Expression des Adhäsionmoleküls CD11b nahm …
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Investigating the role of the CCL2/CCR2 axis in monocytes and its modulation by extracellular nucleotides
… also indicated that although P1, P2X1, P2X4, P2X7, P2Y1, P2Y11, P2Y12, and P2Y13 purinoceptors were unlikely to play a major role, P2Y6 and CCR2 engaged in crosstalk. Cross-desensitisation experiments and studies on P2RY6-knockdown THP-1 cells supported this finding and indicated that a …
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Pharmacological targets for treatment of retinal neurodegenerations: new perspectives [Nuove prospettive sui target farmacologici per il trattamento della neurodegenerazione retinica]
… i recettori purinergici ionotropici P2X3 e P2X4, insieme agli enzimi codificati da CYP2C8, LDHA e MAOB potrebbero essere degni di ulteriori indagini sperimentali per la mancanza di studi preclinici e clinici legati ad essi. In più, si è evidenziato il coinvolgimento di diversi geni noti …