Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"P2X"”.
-
Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system
… and activates both ion channel receptors (P2X) and G protein-coupled receptors (P2Y) on post-synaptic cells. In addition to its role as a neurotransmitter, ATP and other nucleotides are known to be released from injured or ischemic tissue and have been reported to affect inflammatory events …
-
The Role of Extracellular ATP in Dictyostelium discoideum Growth and Development
… cyclic AMP. It is also known that it possesses P2X receptors which are localised on the inside of the cell. Despite the lack of cell surface ATP receptors, previous studies have indicated the existence of Dictyostelium ecto-ATPases and calcium responses to the addition of exogenous ATP. In these …
-
Development of a Microplate-Based Calcium Assay for Studying Desensitization of the P2Y2 Nucleotide Receptor
… of tissues by binding to either the ionotropic P2X family or metabotropic P2Y family of nucleotide receptors. The P2Y2 receptor (P2Y2R) regulates several important processes, such as inflammation, neuroprotection, and NaCl balance on the airway surface and in the kidneys. Prolonged stimulation …
-
Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
… actin-cofilin rod formation by binding to P2X and P2Y cell surface receptors. In our peptide inhibition strategy, we discovered three peptides that inhibit actin-cofilin rod formation in cells undergoing energetic stress. These peptides were found to significantly decrease the length of …
-
Neuronal plasticity in the enteric nervous system motor pathways
… receptors, 5-HT or ATP acting at 5-HT3 or P2X receptors (respectively), but may have depended upon an increased excitability of enteric neurons. Thus, neuronal plasticity of the enteric nervous system is highly adaptable and able to compensate for inhibition of multiple receptors in …
-
Caractérisation du rôle du récepteur P2X7 dans le transport du glucose par les cellules épithéliales intestinales et le contrôle de la glycémie et du métabolisme
Dans l’intestin, le récepteur P2X7, un membre unique de la famille P2X, est fortement exprimé à la surface des cellules épithéliales intestinales le long des villosités, ce qui suggère un autre rôle pour ce récepteur que l’induction de l’apoptose des cellules à l’apex des villosités. Dans des …
-
The role of nucleotides and the P2X7 receptor in radiation induced bystander effect
… pathway that involves both the P2Yand the P2X receptors and activation of these receptors regulate many different functions. The prolific and varied functions of purinergic signalling receptors and the processes they are involved with, either directly or indirectly, suggest a possible …
-
Molekulare und histologische Untersuchungen zur gustatorischen Fettwahrnehmung des Menschen
… auf gustatorische Nervenfasern über P2X-Rezeptormultimere wurde mit Hilfe einer vorherigen Intervention mit einem P2X3 /P2X2/3-spezifischen Antagonisten an der Maus als Modellorganismus im Kurzzeit-Präferenztest untersucht. Es zeigte sich weder eine Beeinträchtigung der Wahrnehmung …
-
The role of the P2X7 receptor in the intestinal inflammatory response to the parasite, Toxoplasma gondii
… tested in this thesis was that the purinergic P2X7 receptor plays a critical role in intestinal inflammation. This was tested by infecting mice with 10 cysts of the ME49 st rain of T. gondii - three strains of mouse were used: BALB/c mice, which are known to be resistant to toxoplasmic ileitis; …
-
Computational study of the structure and function of membrane transport proteins
… interaction, I present my work on the P2X receptor, a non selective cation channel, where we present a unique ion permeation mechanism where the ion permeation pathway is formed by both protein and the lipid molecules. In recent times, Cryo-EM has emerged as a tool for structural …
-
Dining in the Dark ATP Sensing in the Female Aedes Aegypti Mosquito
… any orthologs of vertebrate extracellular P2X or P2Y ATP receptors, we focused on ionotropic receptors (IRs), a large family of chemosensory receptors in insects that has previously been shown to respond to stimuli ranging from olfactory to taste to thermal cues. IRs form heteromeric …
-
The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
The role of the neurotransmitter serotonin (5-HT) in the taste bud is not well understood. Serotonin was long thought to be the neurotransmitter of taste signals from taste receptor cells (TRCs) to the gustatory afferent nerves, but the surprising discovery that this transmission is actually …