Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"P28"”.
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The role of the P28 multigene family in the pathogenesis of Ehrlichia chaffeensis infection.
… protein from a multigene family known as P28/OMP-1. Different alleles from this multigene family are expressed in different host cell types, but the role of this membrane protein remains unknown. Also, few host cell receptors, as well as host-pathogen protein interactions, have been …
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IL-23 and IL-27 expression in dendritic cells and the effects of HIV-1
… LPS stimulation. IL-23p19 and IL-27EBI3 and p28 mRNA expression were evaluated by quantitative real-time RT-PCR (qRT-PCR) and reported as relative expression levels. DCs are readily infected with the ptat, as shown by RT-PCR. The presence of endogenous Tat resulted in a decrease in IL-23p19, …
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EGFR deficiency results in defective hair follicle cycling, resistance to chemotherapy-induced alopecia, and cutaneous inflammation
… follicles remaining in aberrant anagen through P28. Mast cells were examined because follicular mast cell precursors can facilitate the transition into catagen after their maturation and degranulation. Failed catagen progression preceded an inflammatory response in the mutant skin, which was …
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Evaluación de tres tipos de dietas (calostro: leche) en terneras holstein friesian bajo crianza artificial
… (mínimo cuadrado realizado para la variable P28, utilizando la covariable PI mostró que no existen diferencias entre las dietas, y diferencias significativas (P<0.05) para la covariable. Para la variable Cons28, utilizando como variable el PI, se encontró diferencias significativas entre las …
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The role of semaphorin 3A signaling underlying learning and memory formation in the postnatal mouse brain
… decreasing after birth, increasing at day P28, and persisting into older adulthood. We also show that canonical Sema3A signaling is activated in the mouse hippocampus following spatial learning on a novel object place recognition (NOPR) task, suggesting that Sema3A signaling is critical for …
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Identification and Characterization of the Expression Profile of Oligodendrocyte-Derived and Associated Proteins via Unilateral X-Irradation of the Rat Optic Nerve
… reappearance in the 2-D gel protein profile of P28 X-irradiated nerves that, as we have shown previously, undergo a delayed myelination. We then employed mass spectrometric analysis to determine the identities of oligodendrocyte derivedregulated proteins. In this thesis, I will begin by …
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Influence of retinal states on the development and maintenance of retinofugal projections
… activity in Gβ5-/- mice at P7, P12, P14, and P28 correlates with impaired eye-specific segregation of retinal afferents in the LGN at corresponding timepoints. However, Gβ5-/- mice exhibit a normal transition from cholinergic to glutamatergic drive that corresponds with a temporary recovery of …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… postnatal development (postnatal day (P) 8, P14, P28 and P60). RNA sequencing of TrkB.T1 deficient astrocytes isolated at these timepoints revealed aberrant gene expression in astrocyte maturation, while pathway analysis indicated disruptions in synapse organization, neurotransmitter transport and …
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Ο ρόλος κυτταροκινών και βιοχημικών οδών ενδοκυττάριας σηματοδότησης στην παθογένεια των φλεγμονωδών αρθριτίδων
… κύτταρα και αποτελείται από τις υπομονάδες p28 και EBI3. Στα κύτταρα-στόχους ενεργοποιεί το μονοπάτι ενδοκυττάριας σηματοδότησης Jak-STAT και έχει τόσο αντι-φλεγμονώδεις όσο και προ-φλεγμονώδεις λειτουργίες. Στη βιβλιογραφία αναφέρεται ως κυριότερη προ-φλεγμονώδης δράση της IL-27 η επαγωγή …
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Defining Epithelial Cell Fate Dynamics of the Oesophagus during Postnatal Development and Homeostasis
… and cornification, were evident from P28, indicating the transition point towards homeostasis. By looking at the localisation of transcription factors associated with cell fate, I identified a temporal gradient of expression that spans postnatal development. After birth, during a …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… the gain-of-function cohort was assessed at P28 for auditory physiology and at approximately P30 for cochlear histology, without later longitudinal follow-up, the current data cannot determine whether the phenotype represents delayed cochlear maturation that might partially normalize or a …
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Unraveling the Interaction Between Beige Adipocytes and the Sympathetic Nervous System
… actively grow between postnatal day 6 (P6) and P28, overlapping with early postnatal beige adipogenesis. Constitutive deletion of Prdm16 in adipocytes led to a significant reduction in early postnatal beige adipocytes and sympathetic density within this window. Using an inducible, …
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Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration
… E18 (embryonic day 18), P14 (postnatal day 14), P28 and P90 was performed. We observed ~5000 genes change in mRNA abundance, ~530 genes change in AS and ~200 genes change in alternative polyadenylation with minimal overlap among these categories. This indicates that postnatal liver maturation is …
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The role of IL-27 and IL-35 in inflammatory diseases
… gene 3 (EBI3) and a unique IL-12p35 like protein p28. IL-27 is a member of IL-12 family, mainly generated by activated macrophages and dendritic cells. IL-27 binds a receptor composed of WSX-1/TCCR, a ligand-specific chain, and gp130, a signal-transducing molecule shared with other cytokines such …