Global ETD Search
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Showing 1 to 2 of 2 for “"P2 transporter"”.
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Synthetic strategies for potential trypanocides
… further inhibitors. The second part details the P2 strategy. The P2 transporter is a nucleoside transporter unique to T. brucei, which concentrates adenosine. The transporter also binds and selectively concentrates compounds that contain benzamidine and diaminotriazine P2 motifs, which can …
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Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis
… suffer from parasite resistance. The T. brucei P2 transporter, which is encoded by the gene TbAT1, mediates uptake of melaminophenyl arsenicals and diamidines. Reduced P2 uptake is associated with drug resistance. A number of point mutations found in a laboratory derived melarsoprol resistant T. …