Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"P19"”.
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Study of the CDKN2D (P19) locus in Xiphophorus
No abstract prepared.
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Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
… we utilized embryonal carcinomal P19 cells as an in vitro model system. We overexpressed Shh in P19 cells and investigated it’s effects on proliferation and differentiation of P19 cells., P19/Shh, P19 cells overexpressing Shh, proliferated at higher rates than normal P19 cells even …
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SF-1, BUT NOT DAX-1, PREVENTS P19 CELLS FROM DIFFERENTIATING TO EITHER TROMA-1 OR TUJ1 POSITIVE CELLS UPON RA-TREATMENT
… factors (PBX) mRNA and protein levels in P19 cells prevents them from differentiating to either endodermal or neuronal cells. This suggests that PBX is an important regulator of RA-induced differentiation of P19 cells. A microarray analysis was performed to identify PBX regulated genes, …
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Development of RNA-free particles of Cowpea mosaic virus for applications in Nanotechnology
… of silencing deployed in the CPMV-HT system, P19, was modified as the use of wt P19 inhibits regeneration of leaf tissue. A mutant form of P19, R43W, with reduced but still substantial suppressor activity was shown to permit the regeneration of transgenic plants. P19/R43W was used for the …
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Characterization of the TCOF1 Gene Using a Neuroblastoma Cell Line and a Mouse Model
… to affect the cell cycle through the c-myc and p19-Mdm2-p53-p21 pathways respectively. To further characterize the cellular effects of Tcofl, stably transfected NB cell lines with overexpression or knockdown of Tcofl were generated. Growth curves were generated by counting cell numbers. BrdU …
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The roles of the retinoic acid receptors in growth, differentiation and development.
… retinoic acid (RA) induced differentiation of P19 cells. I used mutant RARs to block the normal differentiation of these cells and then analyzed the possible mechanisms by which these mutants are able to exert such effects. My results indicate that overexpression of a dominant negative RAR …
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Transcriptional and Translational Products of Avian Erythroblastosis and Avian Myeloblastosis Viruses
… gag-related polyprotein (p75) which contains the p19 region of the gag gene at its amino terminus. Two-dimensional tryptic peptide mapping indicated that p75 contained novel peptides in addition to those derived from p19. p75 was found to be a phosphoprotein containing a phosphoserine residue. …
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Regulation of the ETn/MusD family of active mouse long terminal repeat retrotransposons
… activity in the undifferentiated cell line P19. I found that three GC-boxes that may function as Sp1/Sp3 binding sites act synergistically and are indispensable for undifferentiated cell-specific promoter activity of the LTR. Sp1 binding partners may be responsible for the restricted ETn …
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The role of small RNAs in C4 photosynthesis
… transgenic C. gynandra containing the viral p19 protein, which is capable of suppressing miRNA activity, were produced. A limited subset of the candidate C4 genes showed a high level of sRNA read alignment. In C. gynandra plants expressing p19 photosynthesis was compromised and transcripts of …
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The Oncogene of Avian Sarcoma Virus UR2 and its Cellular Homologue: Structure, Sequence and Expression
… coding for one of the viral gag proteins, p19. The fused p19 and ros sequences in UR2 code for a polyprotein of 68 kd, P68<sup>gag-ros</sup>, which has an associated tyrosine kinase activity. To elucidate the basis of the functional conservation as well as differences between ros and other …
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Reversibly neutralized perfringolysin O for intracellular delivery of macromolecules/
… siRNA carrier based on the dsRNA-binding protein p19 of the Carnation Italian Ringspot Virus (CIRV). In particular, we matured the affinity of p19 to create clones with some of the highest affinities for siRNA reported to date. Higher affinity correlated with higher potency, with the …
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Does one plus one make two? Investigation of pharmacological effects and cortical injury on the developing brain
… motor maps, forelimb motor maps were evoked at P19. The findings indicate that fluoxetine treatment or HI injury mostly negatively affected functional outcome. The combined treatment with fluoxetine and HI injury only interacted on a limited number of measures. There was no delay in the …
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TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA
… of cell cycle regulators, such as p21 and p14/p19, and the tumor suppressor PTEN in RMS tumor cells. Knock down of TBX2 significantly decreased the proliferation rate of RMS cells. We also found that loss of TBX2 significantly inhibited tumorigenesis of RMS cells by decreasing cell …
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Tissue-specific interactions between oncogenic K-ras and the p19A̳r̳f̳_p53 pathway determine susceptibility to transformation
… By combining K-rasL mice with a reporter for p19Arf expression (Ar FP), we identify a tissue-specific, onocogenic K-ras-dependent expression pattern of 19Arfin lung tumors and sarcomas that correlates with each tissue's genetic requirements for tumorigenesis. Lung tumors, which can arise in …
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Immortalisierung embryonaler Fibroblasten aus Wildtyp und Hupki (Human p53 knock-in) Mäusen durch Veränderungen des p19Arf/p53 Kontrollweges und Erst-Charakterisierung des neuen Prolin 72-kodierenden Hupki-Mausstamms
… oxidativen Stress auf die Zellproliferation aus. P19/ARF-p53 scheint der wichtigste Regulationsmechanismus für die Seneszenz in diesen Zellen zu sein. Mit der Inaktivierung von Tumorsuppressorgenen wie z.B. p53 oder pRb durch Punktmutationen oder Deletionen kann die zelluläre Seneszenz …
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Role of Sonic Hedgehog in Development of the Central Nervous System
… a pluripotent embryonal carcinoma cell line, P19 and investigated the effects of Shh on inducing the expression of nestin, the marker for neural stem/progenitor cells. In early stages, we found that Shh promoted the CNS-specific enhancer of the nestin gene through regulation of E-box on nestin …
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Studio dei meccanismi molecolari coinvolti nel determinismo sintomatologico di piante infette da virus e virus-satelliti
… transformed with another PTGS viral suppressor (p19), and other plants defective for RNA polymerase 6 (involved in systemic silencing), still resulted in yellowing appearance. This, to our opinion, suggests that in our system another possible mechanism is involved.
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Insulin-Like Growth Factor-Binding Protein 2 Supports Hematopoietic Stem Cell Expansion: From In Vitro to In Vivo
… expression of cell cycle inhibitors p21, p16, p19, p57, and PTEN. Moreover, we found that the C-terminus, but not the RGD domain, of extrinsic IGFBP2 was essential for support of HSC activity. Defective signaling of the IGF type I receptor did not rescue the decreased repopulation of HSCs in …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… and retinoic acid signaling during myogenesis in P19 cells. Theses studies have provided a clearer understanding of the pathways that regulate the expression of genes involved in the regulation muscle precursor cell fate.
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Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes
… samples of glucoseresponsive low passage (p19) (MIN6 B1(GSIS)) and non glucose-responsive high passage (p23) (MIN6 B1(Non-GSIS)) was performed. 111 differentially-regulated genes were identified and 16 gene transcripts were selected based on p-value <0.05; fold change 1.2; difference 100 …
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