Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"P107"”.
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P107 negatively regulates the neural precursor pool by repressing Hes1 transcription
… and their long-term ability to self-renew. P107, a member of the pocket protein family of cell cycle regulators has previously been shown in our laboratory to negatively regulate neural precursor cell number and self-renewal (Vanderluit et al., 2004). In this study, we investigated the …
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The roles of Rb, p107, and E2f4 in bone formation and embryonic development
… in vivo roles of three proteins, pRb, E2F4, and p107, in murine embryonic development and in differentiation in vitro. As Rb loss causes embryonic lethality due to placental defects, we adopted a conditional knockout strategy to generate Rb-deficient embryos that survive to birth. This approach …
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The B55α/PP2A Holoenzyme in Cell Cycle Exit, Maturation/Differentiation, and Cancer
… suppressor pRB and two closely related paralogs, p107 and p130. In their hypophosphorylated state, they are associated with E2F transcription factors which result in the repression of transcription of E2F-dependent genes that are required for cell cycle progression. The phosphorylation state of …
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The role of E2F·pocket protein repressive complexes in cell cycle control and differentiation
… of the retinoblastoma susceptibility gene), p107, and p130. This family regulates the GI/S transition by interacting with their major downstream target, the E2F transcription factor. E2F is a heterodimeric protein composed of one DP subunit and one E2F subunit. The E2F family can be …
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Pocket protein family function in mesenchymal tissue development and tumorigenesis
… which includes the closely related proteins p107 and p130. The pocket proteins are critical regulators of the cell cycle and function to restrain proliferation by controlling the activity of the E2F family of transcription factors. The pocket proteins also play an important role in the …
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Molecular analysis of the role of E2F proteins in the pRB pathway
… interactions with the pRB-related proteins p107 and p130. Unlike pRB, mutations in p107 or p130 are not associated with cancer. The different properties of the pRB family may result from the manner in which each protein regulates E2F. To determine how individual E2Fs contribute to the cell …
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Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells
… protein (pRb), and its homologues pRb2/p130 and p107, comprise a gene family which is central in maintaining appropriate cell proliferation and differentiation. The RB proteins bind to and modulate the activity of E2F transcription factors, by way of a unique binding motif termed the pocket …
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The role of E2F4 in the growth suppressive properties of the retinoblastoma protein
… of the pocket protein family, which includes p107 and p130. The pocket proteins have some functional redundancy; however, they have differential binding properties to the E2Fs and make very different contributions to the suppression of tumors. The E2F proteins that associate with the pocket …
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Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis
… In contrast, the closely related pRB homologues, p107 and p130, are known to inhibit cell cycle progression by repressing the E2F transcription factor family, but are not known to have roles in promoting cell differentiation. Interestingly, the Rb promoter contains a critical cassette of binding …
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In vivo studies of repressors of RNA polymerase III transcription
… the tumour suppressors p53 and Rb, as well as p107 and p130, and the basal transcription factor Dr1. The work in this thesis focused on the role of these repressors in regulating Pol III transcription in human cells.
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E7 PROTEINS OF HIGH-RISK (TYPE 16) AND LOW-RISK (TYPE 6) HUMAN PAPILLOMAVIRUSES REGULATE p130 DIFFERENTLY
… E7 proteins target all pRb family members (pRb, p107 and p130) for degradation. LR E7 does not target pRb or p107 for degradation, but does target p130 for degradation. Immunohistochemistry experiments on HPV 6 infected patient biopsies of condyloma acuminata showed that detection of p130 was …
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CRISPR-mediated interrogation of small cell lung cancer
… Using this system, we have demonstrated that p107, a member of the retinoblastoma family that is mutated in a significant fraction of human SCLC tumors, is a functional tumor suppressor in SCLC. Notably, loss of p107 in SCLC tumors resulted in significant phenotypic differences compared with …
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Design of Non-ATP Competitive and Cell Cycle Specific CDK Inhibitors Targeting Cyclin Binding Groove
… for the C-terminal phenylalanine in p21 and p107 derived peptides were used to probe their binding to the specific primary hydrophobic pockets of CDK2/A2 and CDK4/D1 due to a Leu/Val exchange in CBGs. A 3-thienylalanine replacement in SAKRRLFG (p107) context was found to be more potent than …
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The retinoblastoma gene family in tumor suppression and development
… tumor suppressor and the closely related p107 and p130 proteins play important roles in the regulation of both tumorigenesis and tissue-specific differentiation. To determine the role of Rb in development more precisely, we analyzed chimeric embryos and adults made with marked Rb-/- cells. …
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E2F1 induction following DNA damage and oncogene activation
… through binding the RB family proteins (pRb, p107 and p130) and via the E1A N-terminal domain that interacts with different cellular protein complexes including the p300/CBP transcriptional activator and p400/TRRAP chromatin-remodeling complex. The results presented here illustrate novel …
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A possible mechanistic role for microorganisms in the genesis of colorectal cancer.
… and is capable of inactivating p53 and the pRb/p107/p130 protein families. While JCV remains in a latent state for the majority of those infected, we hypothesized that a disturbance to the immunological control allows for JCV to be active again and that the T Antigen may be involved in the …
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Regulation of melanogenesis in conditionally immortalised mouse melanocytes expressing a temperature-sensitive SV40 large T antigen
… suggested that expression of the RB1, p130 and p107 is not altered when DMEL-3 cells were induced to differentiate at the non-permissive temperature. The results from western blot anaysis were inconclusive and require further investigations. Finally, the pigmented cell lines established in the …