Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"P. knowlesi"”.
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Using biophysical tools to explore the erythrocyte preferences of the zoonotic malaria parasite Plasmodium knowlesi
… for the majority of cases and fatalities, *P. knowlesi* is the only zoonotic malaria parasite, infecting both humans and macaques. It is also the closest relative of human-infecting *P. vivax*, which is currently not possible to continuously culture in vitro. Therefore, as well as being an …
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An in vitro chemogenomic screening system to identify the molecular targets of antimalarial drug candidates
… lines in parallel. I transfected PbACs into *P. knowlesi* parasites grown in vitro in human erythrocytes, establishing that PbACs are maintained stably over many generations and the encoded *P. berghei* genes are transcribed in recipient parasites, resulting in systematic target overexpression. …
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The impact of common and rare human genetic variants on erythrocyte invasion by Plasmodium falciparum malaria parasites
… which is used by both P. vivax and P. knowlesi parasites to invade red blood cells (RBCs). A single nucleotide substitution in the promoter of the gene where erythroid-specific transcription factors bind disrupts the expression of the DARC receptor on the surface of RBCs, and …
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Investigation of the role of HSP70 in the uptake of Granzyme B by Malaria parasite-infected erythrocytes
… P. vivax, P. ovale, P. malariae and P. knowlesi. P. falciparum causes the most severe form of the disease. P. falciparum has a complex life cycle in the human and mosquito hosts exposing the parasite to environmental changes, resulting in upregulation of heat shock proteins (Hsps). These …
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Understanding Developmental Decision Making in Malaria Parasites using Single-Cell Transcriptomics
… scRNA-Seq in P. berghei, P. falciparum, and P. knowlesi. This work was followed by specifically profiling the sexual development of wild-type and single knock-out mutant P. berghei parasites using both droplet- and plate-based scRNA-seq. This has led to the identification of novel essential …
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Investigation of azithromycin analogues and proteasome-like inhibitors as quick-killing antimalarials
… falciparum and the zoonotic malaria parasite P. knowlesi. All compounds exhibited low-nanomolar activities against both Plasmodium spp. and showed excellent selectivity for parasites over human cells, suggesting these inhibitors provide viable chemical scaffolds for optimisation. There was no …