Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 176 for “"P. falciparum"”.
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MMV008138 and analogs: potential novel antimalarial agents for P. falciparum
… the development of novel antimalarial agents. P. falciparum parasites synthesize essential isoprenoid precursors, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), via a non-mevalonate pathway: the methylerythritol phosphate (MEP) pathway. This pathway is not utilized by …
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Host cell-pathogen interactions between erythrocytes and P. falciparum: apoptotic mimicry?
… pathogenesis through phagocytosis. Plasmodium falciparum was found to induce PS exposure in both infected and uninfected erythrocytes which could represent a form of apoptotic mimicry; therefore, aiding in parasite perpetuation and immune evasion. A new phagocytic assay was developed, using …
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Characterization of a Novel Sensing Mechanism Governing Antigenic Variation in P. Falciparum
<p>Plasmodium falciparum expresses a multi-copy gene family called var in the intraerythroyctic stages of its life cycle in a mutually exclusive manner. var genes encode the chief antigenic and virulence determinant of P. falciparum, PfEMP1, and switching between active genes results in antigenic …
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Genome-graph based genotyping with applications to highly variable genes in P. falciparum
… genes in the malaria parasite Plasmodium falciparum (Pf ), the motivating example for this thesis. The growing solution in the field is to build graph-based models, representing not one, but a population of genomes from a species, and using these genome graphs as a substrate for read …
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Biomolecular condensation of intrinsically disordered regions in P. falciparum and H. sapiens transcription factors
Plasmodium falciparum is still a major cause of disease and death, especially in sub-Saharan Africa. The organism's complex life cycle is tightly coupled to a carefully controlled gene expression programme, and its highly divergent transcriptional machinery suggests unique mechanisms of …
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The ears of the hippopotamus: Epidemiology and infectivity of asymptomatic P. falciparum and P. vivax malaria infections in Ethiopia
Contains fulltext : 308118.pdf (Publisher’s version ) (Open Access)
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Creating a New Malaria Vaccine Design that uses a Blood Stage P. falciparum Chassis for Non-Blood Stage Antigen Presentation
Malaria is a global disease that affects millions annually and the complex life cycle of the Plasmodium species that cause malaria results in increasing drug resistance and poor vaccine efficacy. Current vaccine designs focus on a single stage in the parasite life cycle and antibody responses are …
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Characterisation of the eukaryotic initiation factor 2alpha kinases of Plasmodium falciparum
… most lethal human malaria parasite, Plasmodium falciparum. As central components of many diverse signalling pathways, protein kinases are crucial for the control of proliferation and differentiation in other eukaryotes; we hypothesise that they play similar roles in P. falciparum. The life cycle …
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The Unconventional Amino Acid Starvation Response of the Malaria Parasite, Plasmodium falciparum
The apicomplexan parasite, Plasmodium falciparum, is the causative agent of the most severe form of malaria, resulting in nearly 1 million deaths each year. The parasite establishes its replicative niche within human erythrocytes, where it degrades massive amounts of host cell hemoglobin, salvaging …
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Using humanised mice to understand Plasmodium falciparum growth and development
… In-vitro culture has been used to study P. falciparum erythrocytic cycle since 1976, allowing the characterisation of genes and testing of therapies. However, it is known that P. falciparum undergoes genetic changes under continuous culture and there are limitations in the host-parasite …
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Transcription regulation in Plasmodium falciparum : functional characterisation of general transcription factor IIB
Plasmodium falciparum is the causative agent of the most severe form of malaria and continues to pose challenges to international healthcare, with high mortality rates and emergence of drug-resistant strains. Plasmodium falciparum has multiple sexual and asexual lifecycle stages within its …
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Characterisation of the plasmodium falciparum HSP70-HSP90 organising protein
Malaria is caused by Plasmodium falciparum (P. falciparum) parasite and accounts for approximately more than half a million deaths yearly. P. falciparum survives under various physiological conditions during its life cycle. The parasite employs its molecular chaperones machinery particularly heat …
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Functional divergence of the RNA polymerase II transcription machinery in Plasmodium falciparum
… functional characterisation of three Plasmodium falciparum general transcription factors - two TBP family proteins designated the TATA-binding protein (TBP) and TBP like protein (TLP), and the P. falciparum orthologue of general transcription factor IIB (TFIIB). Through the biochemical …
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Enabling the in vitro study of long noncoding RNAs to understand their role in Plasmodium falciparum
… (lncRNAs) have been identified in *Plasmodium falciparum*, the parasitic cause for life-threatening malaria, yet their role remains largely undiscovered. Through interactions with nucleic acids and proteins, lncRNAs can modulate gene expression at the transcriptional, post-transcriptional, …
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Developing and applying new methods to understand blood stage growth in Plasmodium falciparum
*Plasmodium falciparum* parasites cause nearly half a million deaths from malaria each year. There is still no highly effective vaccine, and resistance has emerged or is emerging to all current drugs. All the pathology and symptoms associated with malaria are caused by the growth of these parasites …
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Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds
… man are P. vivax, P. malariae, P. ovale and P. falciparum; of which P. falciparum is the most deadly (Bruce-Chwatt 1981 ).
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Investigation of the role of HSP70 in the uptake of Granzyme B by Malaria parasite-infected erythrocytes
… species from the genus Plasmodium, namely P. falciparum, P. vivax, P. ovale, P. malariae and P. knowlesi. P. falciparum causes the most severe form of the disease. P. falciparum has a complex life cycle in the human and mosquito hosts exposing the parasite to environmental changes, resulting …
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Engineering control of eukaryotic translation with application to the malaria parasite Plasmodium falciparum
… or post-transcriptional level. Plasmodium falciparum, the protozoan parasite responsible for the majority of death and sickness due to malaria, remains challenging to manipulate in the laboratory. No robust and generalizable tool for gene expression control has been developed in the …
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