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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 297 for “"P. aeruginosa"”.
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Regulation of the periplasmic stress responses in E. coli and P. aeruginosa
… orthologous pathway in the bacterium Pseudomonas aeruginosa. These pathways sense stress in the periplasm and relay the signal into the cytoplasm by a series of proteolytic cleavages of a transmembrane regulatory protein. In E. coli, I have undertaken the study of the regulation of the cleavage of …
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Regulation of Outer Membrane Porins in P. aeruginosa Strains Collected from Patients with Cystic Fibrosis
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of causing a variety of serve and chronic infections in healthy and immunocompromised hosts. Individuals with the genetic disorder, cystic fibrosis, are particularly susceptible to P. aeruginosa infections, leading to higher …
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Συσχέτιση ιστολογικών, βιοχημικών και αιματολογικών ευρημάτων μετά από χορήγηση LPS P. aeruginosa σε επίμυες wistar: Πειραματική μελέτη
… in order to study the behaviour of three P. aeruginosa Lipopolysaccharides (smooth, rough and deep-rough) after intravenous injection (1.5 mg) in Wistar rats. For each lipopolysaccharide 18 experimental animals were allocated and sacrificed in groups of three at 1th, 2th, 4th and 24th hours, …
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Molecular Rationale Behind the Differential Substrate Specificity of Homologous RND Transporters in E. coli and P. aeruginosa
… coli, and MexB and MexY in Pseudomonas aeruginosa are the most prominent multi-component drug efflux pumps exporting a wide range of substrates ranging from lipophilic to amphiphilic molecules. Despite a comparable overall sequence homology among these RND transporters of E. coli and P. …
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Natural and Synthetic Ligand-Binding Induce Different Pilin Assemblies in vitro and Control P. aeruginosa Bioactivities in vivo, and Development of Bacterial-Motility Enabled Binding Assays
… formed by assembly of pilin proteins on P. aeruginosa are surface proteins that are necessary for host colonization, adhesion on abiotic surfaces, controlling motilities, formation of biofilm, horizontal gene transfer and virulence production of the bacterium. Upon contact with stimuli, pili …
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Nutritional modeling of bacterial infections : physiology and metabolism of Pseudomonas aeruginosa during growth in cystic fibrosis sputum
The Gram-negative bacterium Pseudomonas aeruginosa is a notorious opportunistic pathogen of individuals with the genetic disease cystic fibrosis (CF). Pseudomonas aeruginosa establishes a chronic infection within the CF lung, where the sputum accumulation characteristic of CF provides a complex and …
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Transposon Tn5 mutagenesis in Pseudomonas aeruginosa: a study of Beta-lactamase expression
… inducible class C B-lactamase gene of P. aeruginosa. Transposon mutagenesis was considered an effective method for the identification and subsequent cloning of such regulatory genes. To facilitate identification of Tn5 insertions in P. aeruginosa a transposon Tn5-derivative, Tn5::gen, …
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Discovery and Characterization of Small Molecule Inhibitors of Biofilm Formation in Pseudomonas Aeruginosa
… Specifically, biofilm production in Pseudomonas aeruginosa has been shown to play a significant role in chronic infection of cystic fibrosis (CF) patients. Unfortunately, no clinically effective inhibitors of biofilm formation are available. Through the development and application of convenient …
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Immunmodulatorische Funktion der Surfactant-assoziierten Proteine A und D im Rahmen der lokalen Immunabwehr in der Lunge
… Mukoviszidose-assoziierter Keime wie Pseudomonas aeruginosa, Xanthomonas maltophilia, Burgholderia cepacia und Staphylococcus aureus untersucht. Hierzu wurden zunächst insgesamt 57 klinische Isolate der Bakterien, darunter 35 P. aeruginosa Stämme, durch Sero- beziehungsweise Pyozintypisierung, …
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The influence of mucins on bacterial communities
… how mucins impact established Pseudomonas aeruginosa biofilms. The data reveal that mucins cause disassembly and structural rearrangement in P. aeruginosa biofilms in a mucin concentration and flow rate dependent manner. In Appendix A, I show evidence for the involvement of the bacterial …
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Resistencia a antimicrobianos y virulencia en cepas no-clínicas de pseudomonas aeruginosa
Pseudomonas aeruginosa es un patógeno oportunista, con una gran versatilidad metabólica y extraordinaria habilidad para crecer en distintos nichos ecológicos. P. aeruginosa es uno de los mayores responsables de infecciones nosocomiales, caracterizado por su resistencia a antibióticos y su gran …
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Pseudomonas aeruginosa: estudo epidemiológico e da ação do óxido nítrico sobre biofilmes de amostras mucoides de pacientes com fibrose cística
Atualmente, a Pseudomonas aeruginosa é o bacilo Gram-negativo mais reportado em casos de infecções hospitalares. Sua elevada resistência a antimicrobianos e desinfetantes químicos pode ser explicada, em parte, pela forma de crescimento em biofilmes. A variante mucóide da P. aeruginosa, comumente …
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Influence of Indole and Mixed Culture Growth on Pseudomonas Aeruginosa Biofilm Structure
… that quorum sensing (QS) mutants of Pseudomonas aeruginosa, unable to produce N-acylated homoserine lactone (AHL) signals had altered biofilm structure. During mixed culture growth of P. aeruginosa with Escherichia coli, we found that E. coli production of the organic compound, indole, inhibited …
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A cystic fibrosis infection monitor
P. aeruginosa causes chronic infections in people with the inherited disorder, cystic fibrosis (CF). These chronic infections result in a high rate of morbidity and mortality. Once established, the infections are almost impossible to eradicate. Pulmonary exacerbations, thought to be caused by P. …
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Analysis of the interactions between Aspergillus fumigatus, Pseudomonas aeruginosa and a model of the alveolar surface
Aspergillus fumigatus and Pseudomonas aeruginosa are the most prevalent fungal and bacterial pathogens associated with cystic fibrosis (CF)-related infections, respectively. Coinfection with both pathogens is associated with a deterioration in lung function. Despite the persistence of A. fumigatus …
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Studies on the mode of action of the pyrithione biocides
… of <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> than ZnPT. A <i>Pseudomonas</i>-gap was observed between <i>E. coli</i> and <i>P. aeruginosa</i> upon their exposure to ZnPT. The antimicrobial action of these compounds was neutralised by the presence of EDTA and extracellular …
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Loss of LasR function reshapes inter-species interactions in a polymicrobial cystic fibrosis airway model
… pathogens. One such interloper is Pseudomonas aeruginosa, a WHO high-priority pathogen, infamous for its ability to evade antibiotic clearance. However, P. aeruginosa often has to share the airway environment with a variety of other microbes: these are polymicrobial infections. We now know that …
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Effect of Exopolysaccharides on Pseudomonas aeruginosa Physiology
… biofilm matrix of the opportunistic pathogen P. aeruginosa contains up to three chemically distinct EPS: Pel, Psl, and alginate. EPS production is necessary for robust P. aeruginosa biofilms formation, however, the amount and number of EPS produced varies between strains and growth conditions. …
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Construction of a Pseudomonas aeruginosa Dihydroorotase Mutant and the Discovery of a Novel Link between Pyrimidine Biosynthetic Intermediates and the Ability to Produce Virulence Factors
… to determine if this was also true for P. aeruginosa. Creation of this mutant was a two-step process, as P. aeruginosa has two pyrC genes (pyrC and pyrC2), both of which encode active DHOase enzymes. The pyrC gene was inactivated by gene replacement with a truncated form of the gene. Next, …
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REGULATION OF ALGINATE AND PSL POLYSACCHARIDE EXPRESSOIN IN CLINICAL STRAINS OF PSEUDOMONAS AERUGINOSA
Pseudomonas aeruginosa is an ubiquitous opportunistic pathogen, which is often the terminal pathogen for patients suffering from cystic fibrosis (CF), a genetic disorder affecting the patient's ability to clear respiratory infections. The P. aeruginosa strains most often recovered from patients …
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