Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"P cells"”.
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Functional Dynamics of Primate Retinal Ganglion Cells
… signals. The responses of retinal ganglion cells to such signals provide the means to explore such processing in the retina. Most primate retinal ganglion cells fall into two broad classes, M and P, which have many anatomical and physiological differences. The responses of M and P cells to …
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Multidrug resistance-associated protein 2 (MRP2) and oxaliplatin transport
… membrane vesicles prepared from Sf9 insect cells were used for studies of oxaliplatin transport. A HEK293 cell line stably transfected to over-express the human ABCC2 gene (HEK-MRP2 cells) and its isogenic HEK293 parenteral (HEK-P) cell line, and a panel of seven human gastrointestinal …
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The Immune Microenvironment of Microsatellite Instable Endometrial Cancer
… signaling pathway compared to MSS (n=160) EC (p +cells (114.9 cells/mm<sup>2</sup> vs 75.8 cells/mm<sup>2</sup>; p2 vs 28.0 cells/mm<sup>2</sup>; p+ cells (291.6 cells/mm<sup>2 </sup>vs 240.5 cells/mm<sup>2</sup>; p+ and activated cytotoxic T cells was also increased in the tumor epithelial …
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Structual Visualization of Cytoskeletal Force Tranduction
<p>Cells adhere to their surroundings, mechanically interfacing their intracellular actin cytoskeletons with their local extracellular environments. This enables contractile forces generated by myosin motors to mediate transduction of mechanical cues into biochemical signaling pathways by unclear …
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Investigation of The Role of The Scaffold Protein Shc In Erk Signaling
<p>Cells respond to environmental changes by converting extracellular signals into intracellular events. Scaffolding proteins play important roles in generating specificity in intracellular signaling through the combinatorial use of protein domains and posttranslational modifications. Using the …
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Modulated Functions of The Fanconi Anemia Core Complex
<p>Cells derived from Fanconi anemia (FA) patients are characterized by hypersensitivity to DNA interstrand crosslinks (ICLs), suggesting that FA genes play a role in ICL repair. Fanconi anemia core complex (including A, B, C, E, F, G, L, FAAP20, and FAAP100) activates the Fanconi pathway by …
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
<p>Cells obtain cholesterol in two ways, <em>de novo</em> biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation. Lens cell membrane consists of highest portion …
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Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System
<p>Cells obtain cholesterol in two ways, <em>de novo</em> biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation. Lens cell membrane consists of highest portion …
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SENSITIZATION OF HUMAN OSTEOSARCOMA CELL LINE 143B WITH CALCITRIOL FOR CISPLATIN THERAPY
… migration. Our hypothesis is pretreatment of OS cells with calcitriol would sensitize them for cisplatin therapy leading to decrease in concentration for IC50. Secondary objective was to evaluate the effect of calcitriol on migration and invasion of OS cell lines, and the role of matrix …
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Contact-Dependent Activation of Macrophages by Naive CD4<sup>+</sup> T cells.
<p>Naive T cells are positioned at the origin of adaptive immune responses. The activation of naive T cells is usually viewed from the perspective of IL-2 production and entry into the cell cycle. This activation is antigen specific and MHC restricted via TCR ligation/CD3 signaling but also demands …
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Structural determinants of murine leukemia virus (MLV) reverse transcriptase (RT) important for fidelity and drug resistance in vivo
… phosphotransferase gene. Transfection of ANGIE P cells with wild type or mutated MLV gag-pol expression constructs generated GA-1 virus that was able to undergo only one cycle of viral replication upon infection of D17 cells. The infected D17 cell clones were characterized by staining with X-Gal …
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Biochemical Characterization of Binding Partners of Two Hsp70 Co-Chaperones In Saccharomyces Cerevisiae
<p>Cells are exposed to a variety of environmental and physiological changes including temperature, pH and nutrient availability. These changes cause stress to cells, which results in protein misfolding and altered cellular protein homeostasis. How proteins fold into their three-dimensional …
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Single Unit and Population Analysis of Saccade-related Fastigial Nucleus Activity in the Alert Monkey
… eye position. Similarly, discharge activity of P-cells in the oculomotor vermis does not reveal a prominent eye position-dependency. On the other hand, it is proposed that eye position supports saccadic control via at least some FOR neurones, as some authors found that a minority of FOR neurones …
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Merlin Mediated Regulation of Hair Follicle Morphogenesis
… and maintenance of the skin are epidermal stem cells. Within the epidermis two distinct stem cell compartments exist, the bulge and interfollicular/basal stem cell niches, which play a central role in the regeneration of the epidermis through self-renewal and contribution to the differentiated …
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Mcp-1 Release Modulation Through Interaction of Pulmonary Endothelial Cells and Mesenchymal Stromal Cells
… therapies such as mesenchymal stromal</p> <p>cells (MSCs) have increasingly shown great promise for ischemic stroke recovery</p> <p>with some therapies already in various stages of clinical trials. Intravenous (IV)</p> <p>administration of the MSCs leads to the entrapment of these MSCs in the …
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THE NON-ERYTHROID MEMBRANE SKELETON AND ITS ROLE IN MECHANOTRANSDUCTION
… forces to and from non-erythroid mammalian cells. This spectrin based membrane skeleton has been the focus of much study in the context of red blood cells, as it determines their mechanical properties due to the lack of an extended actin based cytoskeleton. In stark contrast, the …
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Dock180/Elmo proteins are critical regulators of phagocytosis,macropinocytosis and chemotaxis in Dictyostelium
… movement. Aggregation competent Dictyostelium cells can detect and move up CAMP gradients. cAMP stimulation causes a transient localized increase in phosphatidyl inositol (3,4,5) tris phosphate (PIP3) concentration in the plasma membrane at the cell's leading edge. PIP3 binding domain …
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Regulation of The Heat Shock Response By Thiol-Reactive Compounds In The Yeast Saccharomyces Cerevisiae
<p>Cells govern their activities and modulate their interactions with the environment to achieve homeostasis. The heat shock response (HSR) is one of the most well studied fundamental cellular responses to environmental and physiological challenges, resulting in rapid synthesis of heat shock …
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Chemical Approaches to Dynein Inhibition
<p>Cells utilize energy to maintain order within the cytoplasm. Motor proteins are the enzymes that convert the chemical energy contained in adenosine triphosphate (ATP) into directed movement along polarized filaments of actin and tubulin within cells. Dyneins are the primary enzymes that drive …
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The role of Decapentaplegic (Dpp) in Drosophila wing development
… mutant clones are due to the extrusion of mutant cells. The extrusion of tkv bsk double mutant cells correlated with changes in the actin cytoskeleton and a dramatic loss of the apical microtubule web normally present in these cells. These results suggest that Dpp signaling is required for cell …