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Showing 1 to 3 of 3 for “"Oxysterol-induced apoptosis"”.
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The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
… events associated with atherosclerosis. Oxysterols, the major cytotoxic component of OxLDL, induce apoptosis in macrophages by a calcium flux mediated activation of cytosolic phospholipase A<sub>2</sub> resulting in the release of arachidonic acid (AA). Inhibition of AA metabolism has …
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The Signaling Pathway of Oxysterol Induced Apoptosis in Chinese Hamster Ovary (CHO)-K1 Cells.
<p>Apoptosis, a form of genetically programmed cell death, plays a key role in regulation of cellularity of the arterial wall. During atherogenesis, improper apoptosis may cause abnormalities of arterial morphogenesis, wall structural stability, and metabolisms. It has been well established that …
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Mammalian cell cultures as a model system for the determination of cytotoxicity induced by cholesterol oxidation products
Oxysterols are products of cholesterol oxidation, which may be produced endogenously or may be absorbed from the diet where they are commonly found in foods of animal origin. Oxysterols are known to be cyctotoxic to cells in culture and mode of toxicity has been identified as apoptosis in certain …