Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Oxygen delivery"”.
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Modulating tissue mechanics to increase oxygen delivery to tumors
Solid tumors have low oxygen tension - hypoxia - that fuels disease progression and treatment resistance. Thus, strategies for alleviating hypoxia are needed. Two factors affect tissue oxygen levels: oxygen supply via blood vessels and oxygen consumption by cells. I focused on improving supply to …
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Ultrasound-assisted Ice Nucleation, Fibroblast Migration and Oxygen Delivery in Collagen Scaffolds for Tissue Engineering
… structure, and the ability to provide targeted oxygen delivery. Collagen scaffolds were fabricated by freeze-drying and crosslinking using N-(3-Dimethyl-aminopropyl)-N’-ethylcarbodiimide hydrochloride (EDC) with N-Hydroxysuccinimide (NHS). Scaffolds were freeze-dried at -20 °C and crosslinked …
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OXYGEN DELIVERY AND CONSUMPTION DURING HYPOTHERMIC OXYGENATED MACHINE PERFUSION AND THEIR IMPACT ON POST-LIVER TRANSPLANT OUTCOME.
Introduzione Sebbene sia comunemente raccomandato mantenere una pO2 >600 mmHg (80 kPa) per garantire un’adeguata ossigenazione durante la perfusione ipotermica epatica ossigenata con macchina (HOPE), studi recenti hanno evidenziato come l’aumento della produzione di anidride carbonica (CO2) sia …
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Fatigue-Independent Alterations in Muscle Activation and Effort Perception During Forearm Exercise: The Role of Local Oxygen Delivery
… the same exercise intensity is exercise where oxygen delivery is suboptimal, resulting in reduced oxygen levels (oxygenation) in the muscle. When human and animal muscle is electrically stimulated, force produced for a given electrical stimulation decreases when muscle oxygenation is reduced. …
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A validation and feasibility study of the non-invasive measurement of oxygen delivery and consumption after elective major abdominal surgery.
… increase in post-operative metabolic demand and oxygen consumption (V̇O2), which must be met by an increased oxygen delivery (DO2). Historical studies described the increase in V̇O2 in patients after major surgery and presented evidence that the inability to meet this increase oxygen demand and …
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Validation of tissue oxygen saturation determined by near-infrared spectroscopy in canine models of hypoxemia and hemorrhagic shock
… was to evaluate the relationship between tissue oxygen saturation (StO2) and oxygen delivery index (DO2I). Oxygen delivery index is product of two factors arterial oxygen content (CaO2) and cardiac index (CI). In this study the relationship between DO2I and StO2 was evaluated by manipulating both …
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Maternal and placental adaptations to hypoxia
Oxygen is an essential element that is required to sustain life. Oxygen is especially important in the maintenance of pregnancy where proper oxygen delivery to the fetus is crucial. In order to study pregnancy-dependent responses, a physiological stressor such as hypoxia was used to exaggerate …
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Prenatal Cardiovascular Physiology and Early Neurodevelopment in Cyanotic Congenital Heart Disease
… have been linked to disruptions in cerebral oxygenation due to the abnormal cardiac connections and obstructed blood flow that characterize CHD. Recently, our group developed an updated fetal cardiovascular magnetic resonance (CMR) approach to non-invasively assess patient-specific hemoglobin …
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Design of a numerical model for simulation of blood microcirculation and study of sickle cell disease
… sickle cell model is the coupling between oxygen delivery and red blood cell dynamics, which is crucial to understanding sickle cell crises and is unique to this blood disease. Based on an original physical description of polymerizing sickle hemoglobin (HbS), an extensive study of blood …
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The physiological changes of circulatory death with respect to organ donation
… is the lack of concordance between arterial oxygen saturations when measured by pulse oximetry and by arterial blood gas (ABG) analysis. This has demonstrated that saturation assessment by ABG analysis document oxygen saturation being above generally accepted minimal levels for up to 40 …
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Physiological effects of exercise in patients with peripheral vascular disease
… included in the final regression model were peak oxygen uptake, calf muscle oxygenation at 1 min and time-to-minimum calf muscle oxygenation. The results suggest that cardiopulmonary fitness and the ability to match oxygen delivery to metabolic demand are important determinants of walking …
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Cerebral haemodynamics in man: Clinical and applied observations
… brain is exquisitely sensitive to oxygen requiring a constant supply of adequately oxygenated blood to function normally. Cerebral oxygen delivery is dynamic, and alters rapidly in response to changes in physiological and pathological stimuli. Interference with cerebral oxygen …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… hypoxia resulting from decreased maternal oxygen uptake, insufficient oxygen carrying capacity, or compromised oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases Hypoxia …
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The Effect of a PUFA Diet on Human Red Blood Cell Levels of 2, 3-DPG
… of 2,3-DPG which relates to an increased oxygen delivery capability of the red blood cells would indicate the benefit of this type of diet to the individual with a high risk of heart disease.</p>
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Model analysis of oxygen transport and metabolism in skeletal muscle: responses to a change in energy demand
<p>The increase in skeletal muscle oxygen consumption (VO<sub>2</sub>) at the onset of contraction is an indicator of the ability to do work. The VO<sub>2</sub> response to contraction (i.e., VO<sub>2</sub> kinetics) is determined by oxygen delivery (convective and diffusive) to tissue, oxygen …
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Cardiovascular effects of a low and a high dose of fentanyl in the isoflurane anesthetized dog: the influence of the anesthetic-sparing effect and the correction of bradycardia
… a significant reduction in cardiac index and oxygen delivery noted with both doses (p < 0.01) that was not different between treatments. Normal mean arterial pressures were maintained with both treatments despite these effects. Only with the high dose, however, correction of bradycardia caused …
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Optical Cerebral Blood Flow Monitoring of Mice to Men
… which are in turn used to compute tissue oxygen saturation and blood volume (Section 2.13). DCS is a qualitatively different dynamic technique that analyzes rapid temporal fluctuations in tissue-scattered light with a correlation diffusion approach to derive tissue blood flow (Chapter 4). …
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Use of blood oxygenator membrane units in teaching mass balances, friction factor and mass transfer analysis
… laboratory experiments with hollow fiber blood oxygenators allow integration of concepts into already full programs. This work describes three new educational experiments that have been developed to introduce students to concepts of mass balances, mass transfer and momentum transfer as applied …
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The Microcirculation in Trauma and Sepsis
… to outcome or parameters reflecting global oxygen delivery.
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Partial nitrification and oxygen transfer analysis utilizing hollow fiber membrane aeration
… first evaluated to determine the K<sub>L</sub>a oxygen transfer coefficient. Reactor parameters, such as mixing speed, membrane length, and gas pressure, were evaluated to determine how K<sub>L</sub>a was affected by these variables.y This hollow fiber membrane was then used to control oxygen …
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