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Showing 1 to 19 of 19 for “"Oxygen binding"”.
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Effects of Hyperoxia on Thermal Tolerance and Indicators of Hypoxic Stress in Antarctic Fishes That Differ in Expression of Oxygen-Binding Proteins
… Channichthyidae) are unique in lacking the oxygen carrier hemoglobin (Hb) in their blood, leaving them with only 10% of the oxygen-carrying capacity observed in closely related red-blooded fishes. Previous studies have shown that icefishes have lower critical thermal maxima …
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Influx and Efflux of Adenine Nucleotides From Erythrocytes Regulate Oxygen Transport and Systemic Metabolism
… responsible for ensuring a sufficient supply of oxygen to meet activity demands. The mammalian erythrocytes primarily modulate their oxygen-carrying capacity by varying the levels of organic phosphates, such as 2,3-BPG. In other organisms, such as fish, ATP instead of 2,3-BPG is used to modulate …
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Mechanistic studies of magnesium electrodeposition and oxygen reduction for energy storage applications
… reactions for both batteries and fuel cells. The oxygen reduction reaction can be catalyzed to undergo reduction via two pathways. Oxygen binding energy to the catalyst has previously been shown to determine the activity of the catalyst. Here we use a novel set of comparative experiments to …
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Developmental changes in the structure and function of lobster hemocyanin
… decapod crustaceans, contain hemocyanin as the oxygen binding protein. Previous investigations have revealed a great deal about the structural and functional properties of this respiratory pigment, but a number of important questions remain unanswered. No strong correlation has yet been …
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The Purification and Characterization of The Cytochrome D Containing Terminal Oxidase of Escherichia Coli (Bioenergetics, Membranes, Ultracentrifugation)
… prosthetic group. Heme d is probably the site of oxygen binding, since both carbon monoxide and oxygen perturb its spectrum.
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SYNTHESIS, TESTING AND CRYSTALLOGRAPHIC STUDIES OF ALLOSTERIC MODIFIERS OF HEMOGLOBIN
… (Hb) is to bind, transport and deliver oxygen to tissues; made efficient by endogenous effectors, such as protons and 2,3-diphosphoglycerate. Synthetic allosteric effectors of Hb (AEHs) are also known to modulate Hb oxygen affinity, showing potential for the treatment of sickle cell …
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Structure-Function Relationship Studies of the Rhodobacter Sphaeroides Cytochrome AA(3)
… c oxidase have been mutated to mimic the metal binding site of bovine mitochondrial oxidase. Residues in a putative oxygen channel to the active site have been mutated and characterized. It was observed that only the mutations near the active site hinder oxygen binding.
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Developing biophysical markers for anemic disorders through advancing interferometric microscopy
… various functions, are mainly tasked with the oxygen transport in vertebrates through blood circulation. Red blood cells are packed with the hemoglobin, an oxygen-binding molecule, and have unique biophysical properties that are critical in enabling the oxygen delivery and optimization of the …
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PAS Signaling Mechanisms in Aer and Aer2
… aeruginosa both contain PAS domains. Aer senses oxygen (O2) indirectly via an FAD cofactor bound to its PAS domain, while Aer2 directly binds O2 to its PAS b-type heme cofactor. The Aer and Aer2 PAS domains both interact with a signal transduction domain known as a HAMP domain. The PAS-HAMP …
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The Anti-Inflammatory Effects of Low Concentrations of Carbon Monoxide in Human Airway Smooth Muscle Cells
… factor-1 (HIF-1), a stress factor limited by oxygen. Therefore, if CO limits oxygen binding, as suggested by its increased affinity to and inhibition of cytochrome c oxidase, CO’s anti-inflammatory effect could be a result of HIF-1α induction. We hypothesize that CO inhibits GM-CSF release by …
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Design, Structure, And Action Of An Artificial Photosynthetic Reaction Center
… for 150 ms after light absorption at pH 9.5. The binding of ferrous iron extends the charge separated state lifetime to 300 ms at pH 7.5. Providing the tyrosine with a hydrogen bond to histidine increases the yield of the charge separated state but decreases its lifetime. Mutation of a …
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Ligand Diffusion Pathways and Mechanisms for Regulating Oxygen Affinity in Two Model Invertebrate Globins: The E7 Gate and Apolar Tunnel
The major pathway for O 2 binding to mammalian myoglobins (Mbs) and hemoglobins (Hbs) involves transient outward movements of the distal histidine (HisE7), which allows ligand migration into the distal portion of the heme pocket. This E7 gate pathway appears dominant in vertebrate Hbs and Mbs. …
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The Proteomic Response of Northern Elephant Seal (<i>Mirounga Angustirostris</i>) Pups to Physiological Stress During Development
… proteins, skeletal muscle proteins, and oxygen-binding proteins that facilitate the development of diving ability in late-fasting pups. Lastly, changes in the abundance of oxidative stress related proteins showed increased use of antioxidant proteins to control the production of reactive …
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Thermodynamics of oxygen ordering in YBa₂Cu₃O₆₊
… has been built to study and manipulate the oxygen in high temperature superconductors. It uses the principle of cryogenically assisted volumetric titration to precisely set changes in the oxygen content of high-T, samples. The apparatus has been used to study the thermodynamics of oxygen in …
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Characterization and design of hydrogen bonding interactions in oxygen reduction by engineered myoglobins
… residue, brought about not only partial HCO-like oxygen reduction activity, but an unexpected observation – the Cu ion was found to not be necessary for imparting this function, nor did it seem to improve it, in the designed protein. On the other hand the presence and positioning of the tyrosine …
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Understanding structure-function relations in heme-copper oxidase using myoglobin-based enzyme models
Heme-copper oxygen reductases (HCOs) are respiratory enzymes that utilize a heme-copper center to perform the four-electron reduction of oxygen to water. The HCOs share significant structural and sequence homology to another class of metalloenzyme, nitric oxide reductase (NOR), that in turn, …
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Caratterizzazione strutturale e funzionale dei sistemi emoglobinici di due specie di pesci (Mugil cephalus e Ophisurus serpens) e di due varianti emoglobiniche umane (HbRoma e HbF-SS-Monserrato)
… protein that in vertebrates binds reversibly the oxygen and transport it to the tissue through the circulatory sistem. The aim of this study is to contribute to the knowledge of structural-functional relationship of the hemoglobin molecule through structural and funcional characterisation of human …
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Thermodynamic Investigations of Metalloproteins: Metal as Probe and Protein as Probe
… of some fish exhibit significantly lowered oxygen affinity at low pH, allowing for proton-mediated release of O<sub>2</sub>. This phenomenon, known as the Root Effect, serves as a proton-driven pump delivering O<sub>2</sub> to the swim bladders and eyes of the fish. The clam, ,<italic>L. …
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The interactions of cytochrome bo3 from Escherichia coli with its substrates - ubiquinone and oxygen
Heme-copper respiratory oxygen reductases reduce O2 to water and use the redox free energy to generate the proton motive force. Among the heme-copper oxygen reductases are the quinol oxidases, which catalyze the 2-electron oxidation of ubiquinol or menaquinol instead of cytochrome c. Escherichia …