Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Oxycodone"”.
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Stability of heroin metabolites and oxycodone in rat hair and liver during decomposition
… in the first trial, rats were administered oxycodone over five days; in the second trial, rats were administered heroin over nine days then drug abstinent for another nine days. After each respective treatment the rats were sacrificed and buried in controlled burial microcosms. …
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Precision Adjuvant Design Enabling Tailored Nanoparticle Immunization Platforms for Oxycodone and Other Substance Abuse Vaccines
… a precision‑vaccinology framework targeting oxycodone and related opioids. A comprehensive analysis of preclinical and clinical literature demonstrated that adjuvant efficacy is drug‑specific. No single formulation suffices across nicotine, stimulant, and opioid antigens. Structural …
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The Effects of Dopamine D3 Receptor Compounds on Oxycodone Self-Administration and Reinstatement in Female Cynomolgus Monkeys
… of opioid abuse. Specific Aims were to establish oxycodone self-administration under a fixed-ratio (FR) schedule of reinforcement in female cynomolgus monkeys and examine the effects of (±)VK4-40 and (±)VK4-116 versus the mu-opioid receptor antagonist naltrexone (NTX), and to investigate the …
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HIGH TRAIT MOTOR IMPULSIVITY IS AN ANTECEDENT TO COCAINE-SEEKING BUT NOT OXYCODONE-SEEKING BEHAVIOR IN RODENTS
… the hypotheses that abstinence from cocaine and oxycodone would have differential effects on trait motor impulsivity and drug-seeking behavior. We demonstrate that oxycodone- but not cocaine-abstinence altered trait motor impulsivity phenotypes. Additionally, motor impulsivity phenotypes …
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Applications of LC-MS/MS in forensic toxicology for the analysis of drugs and their metabolites
… In Scotland, the number of prescriptions for oxycodone has risen by 430% since prescribing began in 2002. Blood samples from fatalities in the West of Scotland involving oxycodone were analysed using an LC-ESI-MS/MS method developed for the determination of oxycodone and its metabolites in …
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Neuronaalisten kolinergisten nikotiinireseptorien positiivinen ja negatiivinen allosteerinen modulaatio
… nicotine and three different opioids, codeine, oxycodone and tramadol in SH-SY5Y cells. SH-SY5Y cells express endogenously α3* and α7-nAChRs. Binding assays were performed with radioactive ligand [3H]-epibatidine. Functional interactions of nicotine and the opioids were studied with 86Rb+- …
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Codependence: A Novel in Essays
… chronic daily headaches, which she relieves with oxycodone (and sometimes other drugs). The narrative chronicles Amy's relationship with Ryan and her iatrogenic dependence on narcotic painkillers, detoxification, return to opioids following a year spent "clean," and the ways in which her headache …
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Fungal biotransformation of morphine alkaloids
… thebaine, hydrocodone, codeine, oripavine and oxycodone into corresponding nor-compounds in varying yields. The study further focused on the characterization of the enzyme responsible for the biotransformation of thebaine into northebaine by Cunninghamella echinulata. The study clearly showed …
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LC-MS/MS determination of various drugs of abuse and metabolites in municipal wastewater effluent samples
… methamphetamine, morphine, nicotine, and oxycodone) and their various metabolites (acetylmorphine, cotinine, EDDP, amphetamine and benzoylecgonine) in municipal wastewater effluent samples. Samples were collected once daily and drugs were extracted from the wastewater with solid phase …
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Entomotoxicological and Thermal Factors Affecting the Development of Forensically Important Flies
… control. The effects of ante-mortem injection of oxycodone in pigs were examined with respect to insect succession patterns and the development rates of Phormia regina. Pigs were given a subcutaneous injection of oxycodone hydrochloride (3 mg/kg by weight) and antemortem blood samples were …
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Sex differences in synaptic plasticity within the reward system: the role of PKMζ and implications for opioid use disorder
… the nucleus accumbens and it works to blunt oxycodone-taking and motivation in a dose-dependent manner. Taken together these findings suggest there are functional sex differences at many levels within the reward system and gaining a better understanding of these differences could provide …
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Synthesis and Evaluation of Dual-Acting Ligands for Mu Opioid And Neuropeptide FF Receptors
… ?-opioid receptor (MOP) agonists, such as oxycodone, morphine, and fentanyl. Although these drugs provide significant pain relief, they are also associated with unwelcome side effects such as constipation, addiction, physical dependence, respiratory depression, and physiological tolerance …
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Assessing, Modifying, and Combining Data Fields from the Virginia Office of the Chief Medical Examiner (OCME) Dataset and the Virginia Department of Forensic Science (DFS) Datasets in Order to Compare Concentrations of Selected Drugs
… develop tolerances to diphenhydramine, cocaine, oxycodone, hydrocodone, methadone, and morphine. These datasets included the years 2000-2004 and were used to compare the concentrations of these six drugs between people who died from a drug-related cause of death (of the drug of interest) and …
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The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence
… action evoked by the prescription opioid oxycodone, providing early evidence that pimavanserin may suppress impulsive opioid misuse. We explored the mPFC as a potential site of action for the 5-HT2AR to modulate impulsive action using viral-mediated knockdown of 5-HT2AR protein expression. …
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A Two-Pronged Approach to Stemming the Opioid Epidemic: Preclinical Strategies for Substance Use Disorder Medications Development and Liquid Biopsy Detection of Inflammatory Pain
… the reinforcing value of the prescription opioid oxycodone (OxyContin®) and does not possess abuse liability. We also have identified a list of genes associated with high drug relapse vulnerability that should be prioritized as candidates targets for development of SUD medications. Finally, we …
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Drug Combinations in Palliative Care: A Compatibility Study
… opioids: morphine, diamorphine, hydromorphone, oxycodone and alfentanil. The preparation of the combinations replicated clinical practice as close as possible. The combinations were prepared in BD syringes and a CME T34 syringe pump together with its administration set was used for the infusion …
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Lääkitystiedon ajantasaistaminen ja lääkityksen turvatarkastus HYKS Syöpäkeskuksessa uro-onkologian poliklinikalla
… medications were related to enoxaparin (n=6) and oxycodone (n=6). Of the potentially inappropriate medications for over 75 years old, the most common discrepancies were related magnesium (n=8) and metoclopramide (n=5). In the medication review process, 4 acute and 44 non-acute DRPs were identified …
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Optimizing Opioid Prescription for Outpatient Surgery
… equivalent (MME), where one opioid tablet= Oxycodone 5mg= MME of 7.5 per tablet. Data was compared to current Outpatient Procedure Guidelines as set forth by the University of Michigan and Johns Hopkins University. A dashboard was created for physicians using collected data to enable review …
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