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Showing 1 to 14 of 14 for “"OxyR"”.
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Investigating the transcriptional regulation by OxyR in Porphyromonas gingivalis.
… the presence of a transcriptional regulator OxyR which is a homologue of OxyR present in E. coli. P. gingivalis OxyR induces the expression of antioxidant defense genes like sod, ahpC-F, dps to protect the bacteria from oxidative stress. Expression of P. gingivalis OxyR regulon is not very …
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Secondary problems caused by the oxyr response to hydrogen peroxide stress in Escherichia coli
… enzymes. E. coli uses the transcription factor OxyR to sense and respond to H2O2 stress. When the intracellular H2O2 levels rise to 0.2 μM, OxyR is activated via the formation of a disulfide bond, and it induces the transcription of the OxyR regulon. The induced genes include those that scavenge …
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Comparison of induced proteins synthesized in hydrogen peroxide and near-ultraviolet -treated bacterial cells
… overexpressing proteins controlled by the oxyR regulon, and deletion mutants of oxyR. In the oxyR mutants that overexpress specific proteins constitutively, 11 newly synthesized proteins were induced by H2 O2 in S. typhimurium and 14 in E.coli in the initial 50 minutes following treatment. …
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Responses to Reactive Oxygen Species in Escherichia Coli: The Roles of Aconitase a and Fur Protein
… damage. However, induction of fur expression by OxyR restored Fur repression in iron-replete media. Indeed, when the OxyR binding site upstream of fur was disrupted, Hpx- mutants accumulated high concentrations of intracellular free iron and suffered mutagenesis and bacteriostasis. These defects …
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Response of intestinal Escherichia coli to dietary factors in the mouse intestine
… belonging to the oxidative stress regulon oxyR such as alkyl hydroperoxide reductase subunit F (AhpF), DNA protection during starvation protein (Dps) and ferric uptake regulatory protein (Fur), which are required for E. coli’s oxidative stress response, were upregulated in E. coli of mice …
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Testing oxidative-stress hypotheses generated by systems-biology assays
… is regulated by a transcriptional factor, OxyR. A previous microarray study suggested that yaaA, an uncharacterized gene found in many bacteria, was induced by H2O2 in Escherichia coli as part of its OxyR regulon. Here I confirm that yaaA is a key element of H2O2 stress response. In a …
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Functional Genomics and physiology of growth initiation in Salmonella
… synthesis and cellular metabolism. Genes in the OxyR regulon were induced earlier in cold-stored cells, a response coupled with a delay in the expression of Fe2+ acquisition genes, and down-regulation of genes encoding central metabolic enzymes. Together, these findings with physiological tests …
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Characterization of Fe-S Cluster Assembly On the Sufbc2D Complex
… showed that suf transcription is controlled by OxyR (an H2O2 stress response transcription factor), the iron metalloregulatory protein Fur, and the Fe-S transcription factor IscR. While transcriptional regulation of the suf genes has been well characterized, almost nothing is known about Suf …
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Estudo de virulência de Salmonella spp. isolados de linfonodos mesentéricos suinos: uma abordagem utilizando o sequenciamento de genoma completo
… sodC1, phoP, phoQ, tolC, sdiA, entF, fhuA, leuO, oxyR, slyA, fimA, flgL, flgK, fliC) apresentaram 100% de frequência nos isolados. Os genes relacionados as ilhas de patogenicidade, regulação, fimbrias e flagelos se mostraram bem conservados em todos os genomas estudados. Assim, a constante …
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The metabolism of iron-sulfur clusters during hydrogen peroxide stress in escherichia coli
… To protect itself, E. coli activates the OxyR regulon, including genes that encode the Suf iron-sulfur-cluster assembly system. E. coli normally relies on the Isc system for cluster assembly; however, when E. coli scavenger mutants were exposed to low-grade H2O2 stress, Suf was needed to …
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Identification and characterization of a novel class of hydrogen peroxide targets in escherichia coli
… damage by H2O2 are becoming clearer. While the OxyR response increases production of H2O2 scavenging enzymes, it also plays a role in metal homeostasis through regulation of MntH and Dps. These proteins work to increase Mn concentrations, while sequestering Fe in the stressed cell, respectively. …
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The molecular characterisation of the recA locus in the opportunistic pathogen Bacteroides fragilis
… and the anaerobic cellular environment until the oxyR regulated system and the pathogenicity genes are activated.
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Electrogenetic pathways in cyanobacteria
… redox-sensitive transcription factors (e.g. OxyR, PerR) and membrane translocation systems (e.g. ABC) alongside more sporadically conserved regulators (e.g. PrqR, SoxR) and transporters (e.g. MATE), suggesting a complex evolutionary history of ancient mechanisms and environment-specific …
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The mechanism by which manganese protects Escherichia coli from hydrogen peroxide
The goal of this study was to understand the mechanism by which manganese protects cells against reactive oxygen species, particularly H2O2. We showed while manganese transport mutants, mntH, have no growth defect, mntH mutants in strains that cannot scavenge H2O2, Hpx- mntH, failed to grow when …