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Showing 1 to 10 of 10 for “"Oxindoles"”.
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Chiral acyl radicals generated by visible light enable stereoselective access to 3,3-disubstituted oxindoles: application toward the synthesis of (–)- and (+)-physovenine
… stereoselective synthesis of 3,3- disubstituted oxindoles via an additional-cyclisation cascade sequence to acrylamide precursors. 6 oxindoles were produced in up to 85% yield, with moderate diastereoselectivity of up to 2.2:1, but which could be easily separated by standard chromatography to …
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Catalytic enantioselective synthesis of oxindoles and benzofuranones bearing a quaternary stereocenter and reactions of palladium bisphosphine complexes relevant to catalytic C-C bond formation
… of a new method for the construction of oxindoles and benzofuranones bearing quaternary stereocenters is discussed. A planar-chiral PPY derivative catalyzes the O-to-C acyl group migration (Black rearrangement) in a highly efficient and enantioselective manner. The utility of this method …
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Recent advances in copper- and palladium-catalyzed carbon-heteroatom and carbon-carbon bond-formation
… of nucleophiles, including (benz)imidazoles, oxindoles, 2-, 3- and 4-hydroxypyridines, anilines, and aliphatic, benzylic, allylic and propargylic alcohols. In many cases, catalyst optimization and ligand structure are discussed and evaluated. Where applicable, the palladiumand copper-based …
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The development and application of metal-catalyzed processes for organic synthesis
… stabilized carbanions. Chapter 2. Synthesis of Oxindoles from a-Haloacetanilides via Palladium-Catalyzed C-H Functionalization We have discovered a palladium-catalyzed reaction that efficiently produces oxindoles from a-haloacetanilides through a net functionalization of an arene C-H bond. The …
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Organophosphorus-Catalyzed Reductive Functionalization of Nitrocompounds via P(III)/P(V) Redox Couple
… a variety N-functionalized azaheterocycles (oxindoles, indoles, quinoxalinediones, and benzimidazoles). Besides boronic acids, anilines were also introduced as an exogenous coupling partner for novel cross-selective intermolecular N–N bond forming reactivity in the formation of various …
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Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma
… of two different classes of HDM2 SMIs: the spiro-oxindoles (MI-219) and cis-imidazoline (Nutlin-3) in lymphoma cell lines and patient-derived B-lymphoma cells. Surprisingly, results revealed significant quantitative and qualitative differences between these two agents. At the molecular level, …
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Rhodium-Catalyzed Enantioselective Desymmetrizations of Oxabicyclic Alkenes and Alkene Difunctionalization via Nickel-Catalyzed Arylcyanation
… reaction for the synthesis of 3,3-disubstituted oxindoles. This method was inspired by our work on the palladium-catalyzed arylcyanation reaction, originally developed to address challenges in the formal synthesis of (+)-corynoline. This nickel-catalyzed reaction uses an air-stable catalyst …
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New explorations in visible-light mediated energy and single electron transfer for nitrogen heterocycle synthesis
… stereoselective access to 3,3-disubstitued oxindoles via newly developed N-acyl chiral auxiliaries, serving as chiral C1 radical synthons. These acyl radicals are generated under visible-light mediated single electron transfer to N-hydroxyphthalimido esters, which then undergo a radical …