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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Oxindole"”.
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Identification and Quantification using HPLC-ES/MS of Four Pentacyclic Oxindole Alkaloids in Uncaria tomentosa Wild Type
… principal pharmacologically active pentacyclic oxindole alkaloids: Mitraphylline, Isomitraphylline, Uncaria C (pteropodine), and Uncaria E (isopteropodine. In order to optimize growth conditions, media with the essential composition of nutrients were established for growth of the wild type. U. …
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A combinatorial approach to the search for anticonvulsant agents from gou teng and tian ma
… widely used in the treatment of epilepsy. Some oxindole alkaloids of Gou Teng have been shown to be antagonists of NMDA receptor, possibly attributable to the antiepileptic activity. This thesis aims to search for active antiepileptic and neuroprotective agents from Gou Teng, Tian Ma and the new …
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A study of succinic dehydrogenase, indole acetic acid oxidase, nitrate reductase and cytochrome c reductase in Hygrophorus Conicus
… produces at least two more products besides oxindole acetic acid. Attempts to separate and characterize these products were unsuccessful. It is suggested that one of the products has a close structural relationship with o-formaminobenzoyl acetic acid while the other may be 5-hydroxy oxindole …
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An investigation of direct C-alkylation of 2,4-oxazolidinedione and 5-phenyl-2,4-oxazolidinedione utilizing dialkali salt intermediates
… attempts were made to form the dianion of oxindole and selectively alkylate it at the 3-position without the interference of dialkylation at that position. No evidence was obtained which indicated that the dianion had been successfully formed, and the major products afforded from these …
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Enantioselective synthesis of 2,2,5-Tri- and 2,2,5,5-tetrasubstituted tetrahydrofurans and synthesis of diketopiperazine containing natural products
… coupling with indole giving the key quaternary oxindole intermediate. A new protocol for intramolecular reductive coupling of the oxoindole and bis-unsaturated diketopiperazine led to successful construction of the hexacyclic skeleton.
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Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1
… including para-chlorobenzyl, polyphenol, oxindole, or isatin-based units. By changing the architectural scheme of these compounds we hope to effectively change the potency of our inhibitors, and will be able to develop a structure-activity relationship that will allow us to design a more …
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Catalytic promiscuity of two plant P450 enzymes: CYP725A4 from Taxus cuspidata and CYP71B102 from Isatis Tinctoria
… was the main product, while indirubin and 2-oxindole were minor products, as verified by high-performance liquid chromatography (HPLC). Half-strength terrific broth (TB) medium in combination with 5-aminolevulinic acid supplementation and isatin hydrolase coexpression altogether increased …
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Exploring Nickel Catalysis in Carbonyl and Alcohol Addition Reactions
… with aryl halides yields 3-aryl-3-hydroxy-2-oxindole products which are scaffolds for many natural product derivatives. Through high-throughput experimentation (HTE), we were able to discover that 1,2-addition at the carbonyl position of isatins is highly compatible with our established …
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OPENING NEW CHEMICAL SPACE IN DRUG DISCOVERY
… focused on boron-containing derivatives and oxindole-based molecular frameworks, have been successfully carried out.
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Rhodium-Catalyzed Enantioselective Desymmetrizations of Oxabicyclic Alkenes and Alkene Difunctionalization via Nickel-Catalyzed Arylcyanation
… reaction for the synthesis of 3,3-disubstituted oxindoles. This method was inspired by our work on the palladium-catalyzed arylcyanation reaction, originally developed to address challenges in the formal synthesis of (+)-corynoline. This nickel-catalyzed reaction uses an air-stable catalyst …
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Rhodium-Catalyzed Asymmetric Ring Opening of Oxabicyclic Alkenes and Palladium-Catalyzed Carbon-Halogen Bond Forming Reactions
… access to medicinally relevant methylene oxindole scaffolds. In contrast to the analogous protocol using palladium(0) catalysts, the reaction is initiated by an alkyne chloropalladation step, followed by intramolecular cross-coupling with a carbamoyl chloride. Experimental and …
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New explorations in visible-light mediated energy and single electron transfer for nitrogen heterocycle synthesis
… stereoselective access to 3,3-disubstitued oxindoles via newly developed N-acyl chiral auxiliaries, serving as chiral C1 radical synthons. These acyl radicals are generated under visible-light mediated single electron transfer to N-hydroxyphthalimido esters, which then undergo a radical …
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Organokatalytická příprava spirocyklických sloučenin odvozených od heterocyklů
Tato bakalářská práce se zaměřuje na enantioselektivní syntézu heterocyklicých spirosloučenin za využití organokatalytického přístupu. První část práce se zabývá enantioselektivní přípravou spirosloučenin reakcí α,β-nenasycených aldehydů s heterocyklickými sloučeninami, při které je použit chirální …