Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Oxidopyrylium."”.
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Mechanistic and Synthetic Studies of Oxidopyrylium Cycloaddition Reactions
… our examination of 3-hydroxy-4-pyrone-derived oxidopyrylium cycloadditions in both mechanistic considerations as well as the unique synthetic advancements of their corresponding cycloadducts. Chapter 1 is a literature review where we specifically outline the use of oxidopyrylium cycloadditions …
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Discovery and Development of a Three-Component Oxidopyrylium Cycloaddition and Its Application Towards alpha-Hydroxytropolone Synthesis
… to these molecules, our laboratory utilizes an oxidopyrylium cycloaddition/ring-opening strategy. During our synthetic investigations, we recently discovered a three-component oxidopyrylium cycloaddition that generates novel 8‑oxabicyclo[3,2,1]octene products. In <strong>Chapter II</strong>, the …
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Studies Toward a General Synthesis of Poly-Substituted Alpha-Hydroxytropolones
… 2: A brief review on β-hydroxy-γ-pyrone based oxidopyrylium cycloadditions will be presented as well as important oxidopyrylium cycloaddition/ring opening procedures to yield natural tropolone products. Research from the Murelli laboratory will be highlighted. This chapter will discuss a new …
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Synthesis and Evaluation of Densely-Functionalized Troponoids
… This body of work has focused primarily on an oxidopyrylium cycloaddition/ring-opening strategy for the synthesis and biochemical evaluation of troponoids for assistance in a variety of medicinal chemistry studies. In Chapter 1, we outline the use of this synthetic strategy in the profiling of …
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Synthesis of Biologically Active Tropolones and Stereochemically Rich Compounds via Cross-Coupling Reactions
… The Murelli lab have therefore developed an oxidopyrylium cycloaddition/ring-opening strategy that is able to generate polysubstituted alpha-HTs starting from kojic acid, a cheap and readily available reagent. Adding to this, the Murelli lab have developed a scalable and reproducible …
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Studies on the Synthesis, Function, and Properties of Troponoids
… groups. Here we discuss our use of a dimerized oxidopyrylium ylide in [5+2] cycloadditions to generate novel tropolone probes for studying the rotational barriers of ketones appended to tropolones. These novel structures were subjected to variable temperature nuclear magnetic resonance …
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Exploring hetero-atom derivatization in maltols and flavonols : the effect on reactivity of flavonol dioxygenation.
Flavonols are a class of polyphenolic natural products containing a 3-hydroxy pyrone core. They have been found to have several desirable properties such as anti-fungal, anti-bacterial, anti-mutagenic and anti-carcinogenic properties and they act as UV filters in plants. Flavonols display dual …