Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1378 for “"Oxidative stress"”.
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Oxidative stress biomarkers in dementia
… thus far suggests that increased levels of oxidative stress and vascular risk factors are two major contributors, amongst others, to AD development. The thesis aimed to investigate markers of oxidative stress in AD plasma. Moreover, the oxidative status of specific proteins was investigated …
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Oxidative stress and seed survival
… with a view to determining the role of oxidative stress as a diagnostic marker for desiccation tolerance.<br/>Axes of non-senescent highly viable recalcitrant seeds of horse chestnut were metabolically active, contained products of lipid peroxidation, displayed low levels of enzymatic …
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Oxidative stress in anoxic habitats
… enzymes. Virtually all life forms experience oxidative stress to some degree, and they are all equipped with mechanisms to protect themselves and to repair the damaged moieties. While oxidative stress is an obvious caveat of oxic life, it can also affect the organisms in anoxic environments …
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Role of oxidative stress in photoreceptor degeneration
… and represent the major cellular source of oxidative stress. ROS are capable of attacking molecules such as DNA, proteins and lipids, and of compromising either the structural and functional integrity or the survival of cells. Mitochondria also play a key role in apoptosis, the major …
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Regulation of The Oxidative Stress Response By Arid1A
… ARID1A is required to protect cancer cells from oxidative stress. In the absence of ARID1A, intracellular ROS levels were increased, and this increase was required for increased cell growth upon ARID1A depletion.</p> <p> Next, I investigated the relationship between ARID1A and NRF2, the major …
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Chronic oxidative stress and susceptibility to renal carcinogenesis
Kidneys are important target organ for oxidative stress mediated injury and oxidative stress has been suggested as a common pathway shared by multiple risk factors of kidney cancer. But there is no experimental evidence to show direct role of oxidative stress in kidney cancer. In this study, our …
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Biomarkers of oxidative stress in models of schizophrenia.
Increasing evidence indicates that oxidative injury exists in schizophrenia. Although it may not be the main cause, oxidative damage has been suggested to contribute to the pathophysiology and may account for deteriorating course and poor outcome in schizophrenia. There is increasing interest in …
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HPV16 E6* Induces Oxidative Stress and DNA Damage
… in both HPV+ and HPV- cells. This increased oxidative stress led to higher levels of DNA damage. The observed increase in ROS may be due to a decrease in cellular anti-oxidant activity, as we found that E6* expression also led to decreased expression of SOD and Gpx, These studies indicate …
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Free radical mediated oxidative stress in plant cancers
… for the first time an in depth examination of oxidative stress and antioxidant protection in plant tissue cultures undergoing various stages of ageing and neoplastic progression towards a cancerous state. Two experimental systems were investigated: (1) <i>Beta Vulgaris</i> cultures comprising …
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Oil palm phenolics suppresses oxidative stress and inflammation
… to protect glial cells and chemical systems from oxidative stress and inflammation were studied. The antioxidant effects of OPP were analyzed based on its ability to act as a direct antioxidant against Reactive Oxygen Species (ROS), the selective expression of several antioxidant enzymes when …
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The Role of Oxidative Stress in Skeletal Muscle Regeneration
… NAC administration resulted in a decrease in oxidative stress levels that was associated with significant survival benefit during oxidative damage. When used in vivo, NAC administration also showed decrease in tissue fibrosis, increase in myogenesis, angiogenesis and muscle function. These …
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Exercise and Oxidative Stress: Implications in Health and Disease
… compromised antioxidant defences and increased oxidative stress. Study two investigated the effects of exhaustive exercise on these parameters in type 1 diabetic patients. No selective exercise difference (<i>time x group, P </i>> 0.05) was observed in free radical production between groups, …
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Gamma-Glutamyltransferase- Is it a Biomarker of oxidative stress?
… the extracellular medium that is associated with oxidative stress. Hydrogen peroxide and menadione were used to induce oxidative stress in human fetal liver (HFL cells) and human renal proximal tubules epithelial cells (hRPTE cells). The results suggest that there is an increased excretion of GGT …
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Mechanisms of Oxidative Stress Resistance in Porphyromonas gingivalis W83
… gingivalis</em>must employ mechanisms to avoid oxidative stress generated by reactive oxygen species during phagocytosis, or the occasional exposure to air. Presently, only three proteins with antioxidant enzymatic function have been identified as playing a role in oxidative stress resistance in …
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Noxious Cellular Injury Triggers an Oxidative Stress Gene Response
… a series of complex processes that can induce oxidative stress by elevating intracellular reactive oxygen species (ROS) levels. In this study, we used RNA-seq and qPCR to examine the molecular signature of Human Embryonic Kidney cells (HEK-293T) stimulated with <em>Crotalus atrox </em>(CA) …
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Chemical probes for the study of mitochondrial oxidative stress
The implication of oxidative stress in ageing, and various disease states, has resulted in great interest in understanding the processes associated with it. Mitochondria are the major source of reactive oxygen species (ROS) via the electron transport chain. ROS may be free radicals, or molecules …
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Excitotoxicity, oxidative stress and neuroprotection in cerebellar granule neurones
Neuronal death due to excitotoxicity and oxidative stress is a critical part of several major disease processes, including ischaemic brain damage and Alzheimer’s disease. This study used cultures of cerebellar granule neurones as a model for investigation of these processes, considering both their …
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Consequences of Endogenous Mitochondrial Oxidative Stress in the Heart
<p>For many years, it has been proposed that oxidative stress within the mitochondria causes mutations to the mitochondrial genome, resulting in changes in copy number per single cell. Ultimately, this compensatory increase in mtDNA, coupled with an increase in mutations, has been suggested to play …
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Estrogen's Effects on Oxidative Stress Levels in Glial Cells
… any protective effect on astrocytes exposed to oxidative stress. We measured the oxidative stress level ofN1 1321 glial cells that were exposed to 600pM hydrogen peroxide. The astrocytes were pretreated for one hour with one of four types of estrogen at four concentrations ranging from 10nM - 10 …
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