Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Oxidative injury"”.
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Impact of mtDNA Signature on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Progression and Cardiometabolic Outcomes in Mice
… linked to differences in bioenergetic function, oxidative stress, and disease susceptibility. Given mitochondria’s central role in metabolism and their unique maternal genomes, mtDNA haplotypes, shaped by evolutionary adaptation, may influence CMDs onset and progression, yet this relationship …
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Interferon-Dependent Mechanisms of Disease Pathogenesis in Respiratory Syncytial Virus Infection
… of protective antioxidant enzyme (AOEs) leads to oxidative injury and lung inflammation. We hypothesize that strategies directed to block IFN I activity and to supplement the airway mucosa with AOEs could serve as new therapeutic approaches for RSV infections. In studies that are described in this …
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Biomarkers of oxidative stress in models of schizophrenia.
Increasing evidence indicates that oxidative injury exists in schizophrenia. Although it may not be the main cause, oxidative damage has been suggested to contribute to the pathophysiology and may account for deteriorating course and poor outcome in schizophrenia. There is increasing interest in …
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
<p>In response to oxidative injury murine tumors depend upon the GSH oxidation-reduction cycle. The susceptibility of tumor cells to lysis by a flux of H<sub>2</sub>O<sub>2</sub>, such as generated by granulocytes or activated macrophages, or by the enzyme glucose oxidase, was augmented by …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
… effect of increased susceptibility to oxidative injury in certain pathological conditions. In summary, findings from my study yielded novel insights of how gut-liver signaling regulates the complex hepatic metabolic pathways and how targeting the gut-liver signaling axis could improve …
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Evaluation of a novel mitochondria‐targeted anti-oxidant therapy for ischaemia-reperfusion injury in renal transplantation
Ischaemia-reperfusion (IR) injury makes a major contribution to graft damage during kidney transplantation and increases the risks of primary non-function, delayed graft function and rejection. Oxidative damage to mitochondria is a key early event in IR injury. The aim of this project was to …
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Protective effects of regular exercise and Korea red ginseng against high-fat diet-increased renal injury in ᴅ-galactose-induced aging rats
… seen commonly in aging. Aging further increase oxidative stress in the kidney and are associated with reduced renal function. Aging is progressive accumulation of oxidative agents. Advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs) formation has been implicated …