Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"Oxidative Phosphorylation (OXPHOS)"”.
-
Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation
Metabolic switch from oxidative phosphorylation (OxPhos) to glycolysis is a key feature of inflammatory response in macrophages, but how this switch occurs in response to inflammatory signals and how it precisely contributes to macrophage function is still obscure. Here we show that stimulation of …
-
PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
… and HER2 receptors, exhibits high glycolytic and oxidative phosphorylation (OXPHOS) activity, contributing to poor prognosis and metastasis. The ATP5A1 protein, a key component of mitochondrial ATP synthase, plays a central role in energy metabolism and is linked to cancer-specific metabolic …
-
Significance of DNA base excision repair in the maintenance of mitochondrial function in Saccharomyces cerevisiae /
… being the major site of ATP production via oxidative phosphorylation (OXPHOS). Accumulation of mtDNA mutations have been linked to the development of respiratory dysfunction, apoptosis, and aging. Base excision repair (BER) is the major and the only certain repair pathway existing in …
-
MIR-181A/B INHIBITION AS A NEW STRATEGY FOR MITOCHONDRIAL DISEASE TREATMENT
… of rare inherited disorders caused by defective oxidative phosphorylation (OXPHOS) and defined by a wide range of clinical phenotypes. MDs show extreme genetic heterogeneity, which makes the development of efficient treatments particularly difficult. Indeed, despite recent progress, no effective …
-
DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… excitation-contraction coupling via aerobic oxidative phosphorylation (OXPHOS) process. Accumulation of reactive oxygen species (ROS), by-products of mitochondrial respiration, within dysfunctional mitochondria results in the activation of cardiac cell death pathways and has been associated …
-
Functional responses of cardiac and skeletal muscle mitochondria to short-term obesity: are all obesities the same?
… of lipids in squirrels, but not in mice. Cardiac oxidative phosphorylation (OXPHOS) capacity significantly increased only in squirrels, and exhibited a significantly greater capacity to oxidize pyruvate in the presence of lipids. No significant change was observed in mice cardiac mitochondria. …
-
Investigating IL-15 Metabolic Impact and Its Mechanism of Action in Skeletal Muscle Cells
… Glucose transporter 4 (GLUT4) translocation, oxidative phosphorylation (OXPHOS) complexes protein expression, troponin T expression and Akt, AMPK and Acetyl-CoA Carboxylase (ACC) phosphorylation state. Acute IL-15 treatment increased glucose uptake without activating insulin signaling pathway …
-
Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer
… of invasive MDA-MB-231 cells, and restore oxidative phosphorylation (OXPHOS) activity to these cells. These data suggest that the mitochondrial dysfunction present in these cells is partially due to their low PNC1 expression. Conversely, we observed that suppression of PNC1 in MCF-7 cells …
-
Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
… these tumors were characterized by decreased oxidative phosphorylation (OXPHOS) and increased immune infiltration signatures compared to MBMs from patients with concurrent ECMs. To further characterize the role of OXPHOS in MBM progression, intra-patient variation in OXPHOS gene expression was …
-
Ankyrin Dependent Mitochondrial Function and Bioenergetics In The Heart
… membrane potential (MMP), and inefficient oxidative phosphorylation (OXPHOS)/ATP production. Altogether, these results further elucidate the role of AnkB in the heart and provide novel insights into the mitochondrial aspect of AnkB related cardiac dysfunction.</p>
-
Fbxw7 Triggers Degradation Of Kmt2d To Favor Growth Of Mature B-Type Malignant Cells
… phosphodegrons are phosphorylated in cells and phosphorylation is required for KMT2D to interact with FBXW7. FBXW7 functions as a bona fide E3 ubiquitin ligase for KMT2D in mediating K48-linked ubiquitination and proteasomal degradation of KMT2D. Using both in vitro and in vivo functional …
-
Effects of Trimethylamine N-Oxide on Mouse Embryonic Stem Cell Properties
… of compensatory glycolysis upon inhibition of oxidative phosphorylation (OxPHOS). It also significantly increased the rate of OxPHOS, maximal respiratory capacity, and respiratory reserve. These findings indicate that TMAO induced a metabolic switch of mESCs from high glycolytic activity to …
-
The effects of complex I deficiency on neurogenesis and white matter development in a mouse model of Leigh Syndrome (LS)
… mitochondrial respiratory-chain complexes impair oxidative phosphorylation (OXPHOS), leading to bioenergetic failure in vulnerable brain regions resulting in the characteristic bilateral, symmetric deep gray matter lesions observed on MRI. While this neuron-centric perspective helps explain …
-
THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE
… of photosensitizers with the ability to target oxidative phosphorylation (OXPHOS) in pathogenic and malignant T cells. The photosensitizers are also potent stimulators of P-glycoprotein (P-gp). Enhanced P-gp activity promotes the efficient removal of photosensitizer not sequestered in …
-
The Effect of Alhagi maurorum Medik on Mitochondrial Function
… levels, mitochondrial membrane potential (MMP), oxidative phosphorylation (OXPHOS), calcium homeostasis and mitochondrial morphology in MCF-7 and MCF-10-A (control) cells after treatment with Alhagi maurorum for 24hr and its main bioactive compound hordenine for 6hr, 24hr, and 48hr are observed. …
-
OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
… melanoma tumors that pharmacologic inhibition of oxidative phosphorylation (OXPHOS) results in increased expression of genes consistent with activated anti-tumor immune responses. <strong>The central hypothesis of this dissertation is that OXPHOS plays a critical role in the pathogenesis and …
-
Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including <em>PPARGC1A</em> or <em>PGC1α</em>) than patient-matched extracranial metastases (ECMs). <strong>Thus, the central hypothesis of this dissertation is that </strong><strong>OXPHOS plays a critical …
-
Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans
… tissues. Mitochondrial ATP production by oxidative phosphorylation (OXPHOS) is known to play a critical regulatory role in glucose stimulated insulin secretion (GSIS). The overall aim of this thesis was to explore the influence of genetic and epigenetic variation on OXPHOS, islet function …
-
Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
… necessary for mitochondrial activity, including oxidative phosphorylation (OXPHOS) complexes and transporters. Mitochondrial respiratory chain (MRC) complexes, which generate ATP by OXPHOS, associate in higher-order assemblies, known as supercomplexes (SC), that are structurally interdependent. …
-
Protein factors involved in the biogenesis of the mitochondrial ribosome
… encodes thirteen polypeptide components of the oxidative phosphorylation (OxPhos) system, and the mitochondrial (mt-) rRNAs and tRNAs required for their translation. The maturation of the mitochondrial ribosome requires both mt-rRNAs to undergo post-transcriptional chemical modifications, …
Page 1 of 2