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Showing 1 to 15 of 15 for “"Oxadiazole"”.
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Structural and spectroscopical study of crystals of 1,3,4-oxadiazole derivatives at high pressure
Die Suche nach neuen Materialien von technischem Interesse hat in den letzten Jahren neue Antriebe zu der Untersuchung organischer Verbindungen gegeben. Organische Substanzen haben viele Vorteile wie z.B. die Möglichkeit, ihre Eigenschaften durch verschiedene chemische und physikalische Techniken …
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Development of Novel Methods for the Installation of Trifluoromethyl/Boryl and 1,2,4-Oxadiazole Moieties
… 5 provides insight into the synthesis of 1,2,4-Oxadiazoles which are privileged scaffolds in medicinal chemistry. The developed reaction occurs under metal-free conditions using sodium carbonate to couple N-hydroxylbenzenecarbonimodyl chlorides with nitriles.
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Preparation and characterization of vapour deposited films based on substituted 2,5-diphenyl-1,3,4-oxadiazole derivatives
… untersuchten Ts-Bereich bilden etherverbrückte Oxadiazole immer geordnete Schichten und die Schichtperiodicität hängt linear von der Längen der aliphatischen Ketten, während sich bei den amidverbrückten Oxadiazolen nur bei hohen Ts geordnete Schichten bilden können. Diese Unterschiede sind auf …
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Antiviral Agents: 3,5-Disubstituted 1,2,4-Oxadiazole Derivatives and Novel Peptidomimetics Containing Hydroxyethyl Isostere and Imidazolidinone Structures
<p>The search for new compounds with biological activity is the major goal of medicinal research.</p><p>One way to discover new lead compounds is the screening of large compound libraries, followed by the optimization of the found compounds. With this method, <b>A3</b> was recently identified as a …
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SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL ANTIPARASITIC AND ANTICANCER AGENTS
… hit compounds featuring 1,3,4- and 1,2,4-oxadiazole scaffolds linked to a 3-bromo-4,5-dihydroisoxazole (BDHI) core. Structure-activity relationship (SAR) exploration guided the synthesis of novel derivatives, incorporating modifications to enhance potency, drug-like properties, and …
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New Luminescent Organic and Organomatallic Materials for OLED Applications
… of fluorescent carbazole-2,5-diphenyl-1,3,4-oxadiazole dyad molecules and in which the topology and electronic properties are systematically varied by chemical modification. Cyclic voltammetric data, HOMO-LUMO calculations, and X-ray crystallographic analyses are also presented. Our study …
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New Strategies for the Qualitative and Quantitative Analysis of Nitrofural and Its New Derivatives // Нови стратегии за качествения и количествен анализ на Nitrofural и неговите нови производни
… for synthesising new 5-(5-nitrofuran-2-yl)-1,3,4-oxadiazole derivatives with a precursor Nitrofural have been investigated.
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Design, synthesis, and evaluation of bioactive molecules; Chiral polyvinylpyrrolidones supported Cu/Au nanoclusters catalyzed cyclization of 5-substituted nona-1,8-dien-5-ols
… ischemia and reperfusion (I/R) injury. Oxadiazole derivatives were designed as T-type calcium channel inhibitors, which have potential application in the treatment of seizure and epilepsy. Tricyclic pyrone derivatives were reported as anti-Alzheimer lead compounds in previous research …
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Electroactive Conjugated Polymers as Charge-Transport Materials for Optoelectronic Thin-Film Devices
… excited states. With the carbazole-substituted oxadiazoles 1–3 it was shown that on the one hand the carbazole functionality is suitable for enabling the electrochemical polymerisation of the monomers and on the other hand it facilitates reversible p-doping of the resultant polymers. Although …
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Localised states in organic semiconductors and their detection
… Trisphenylquinoxaline und Oxadiazole), die wegen ihrer technologischen Bedeutung ausgewählt wurden, zeigen komplexes thermisches Verhalten. Insbesondere hoch geordnete Filme eines amphiphil substituierten 2-(p-nitrophenyl)-5-(p-undecylamidophenyl)-1,3,4-oxadiazols (NADPO) …
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Structure-Activity Relationship Studies of Imidazo[4,5-b]pyrazine Derivatives as Mitochondrial Uncouplers and their Potential in the Treatment of Obesity
… electrophile partner, in situ reduction of the oxadiazole fragment followed by cyclization afforded imidazolopyrazines in moderate to good yields. The selection of different orthoesters as electrophiles also allowed functionalization on the 2-position of the imidazole ring. This new method was …
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Determining The Excited State Properties of Novel Aryleneethynylenes
… systems. 2,5- bis(Phenylethynyl)-1,3,4-oxadiazole exhibited high energy absorption and emission maxima, as well as relatively narrow absorption and emission profiles, in contrast to the broad profiles of the other electron–deficient systems. The benzofurazan se- ries exhibited broad, …