Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Overall survival time"”.
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Joint Modeling of Tumor Size and Time-to-Event
<p>In clinical trials, time-to-event data (survival component) and longitudinal data (longitudinal component) are often collected. In order to model these two components simultaneously, the joint modeling approach which can reduce potential biases and improve the efficiency in estimating treatment …
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Optimization and toxocologic effects of cancer immuno-electrogene therapy using a tumor-targeted interleukin-12 gene construct
… for dogs with partial responses; and extended overall survival time. For the purpose of meeting pre-clinical safety requirements for an Investigational New Drug filing, we assessed the safety of tumor-targeted interleukin-12 (ttIL-12) when administered by EGT in C3H/HeJ mice by identifying an …
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Molecular Characterization of Glioblastoma Cancer Stem Cells
… aggressive, highly vascular tumors that have an overall survival time less than 14 months, and current therapies provide little improvement in the disease course and outcome. While glioblastoma multiforme (GBM) patients present uniform histological phenotypes, the molecular determinants of the …
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Flow cytometry in the diagnosis and prognosis of canine lymphoma and leukemia
… outcome was defined by a reduced first remission time (FRT) and/or overall survival time (ST). In this two-part retrospective study, two-thirds of patients (modeling group, n=106) were randomly selected to construct a multi-variable statistical model to identify test variables which showed a …
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Investigation of the beta 2 adrenergic receptor (B2-AR) pathway in canine hemangiosarcoma
… there has been minimal improvement in the overall survival time even with standard treatment, which includes surgery and chemotherapy. Propranolol, an oral drug originally developed for the treatment of cardiovascular diseases, has been successfully used for the treatment of infantile …
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NEW INSIGHTS INTO PATHOGENESIS AND PROGNOSIS OF CANINE SARCOMAS
… variables on local recurrence (LR) and overall survival time (OST) in a large series of retrospectively collected surgically excised cPWTs finding that histological grade, tumor necrosis, mitotic count, status of surgical margins, tumor ulceration, and location on distal extremities had …
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Investigation of Equus caballus papillomavirus type-2 (EcPV-2) in asymptomatic and symptomatic horses
… In Chapter 3, we measure clinical outcome (overall survival time) through the use of a retrospective survey, issued to Western Canadian veterinary practitioners. We show that the EcPV-2 status of genital SCCs is not a prognosticating factor. We identify treatment status and recurrence as …