Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Overall Survival (OS)"”.
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HIV-associated Hodgkin lymphoma at Groote Schuur Hospital, Western Cape, South Africa
… rate in the world. There is currently no 5-year overall survival (OS) outcome based data for HIV-associated HL from SA. Methods: A bone marrow database was compiled of all bone marrow biopsies (BMB) reported at National Health Laboratory Service (NHLS) Groote Schuur Hospital (GSH) between January …
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Kasos adenokarcinomos diagnostinių ir prognostinių biožymenų paieška /
Survival rates from pancreatic cancer have remained stagnant for decades due to the heterogenic nature of the disease. This dissertation aimed to find a new advanced biomarker and evaluate its clinical capabilities, thus enabling more individualised pancreatic cancer management. Between 2013 and …
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Prognostic Factor Analysis of Patients with Advanced Non-Small Cell Lung Cancer Treated with Palliative Chemotherapy
BACKGROUND: Alterations in apoptosis and DNA damage repair related proteins are associated with resistance to chemotherapy, which is the most important cause of treatment failure in non small cell lung cancer (NSCLC). MATERIALS AND METHODS: Pretreatment tumor biopsy specimens from 50 patients with …
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Treatment Outcomes in Children with Very High Risk Acute Lymphoblastic Leukemia Intended to Treat with Allogeneic Hematopoietic Stem Cell Transplantation
The prognosis of very high risk group acute lymphoblastic leukemia (VHR ALL) in childhood is generally poor in spite of intensive chemotherapy. Recently, allogeneic hematopoietic stem cell transplantation (Allo-HSCT) was use to treat the patients with VHR ALL. We studied the clinical course and …
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Clinical Impact of A Highly Sensitive Next-Generation Sequencing Measurable Residual Disease Assay In Patients With Acute Lymphoblastic Leukemia
… residual disease (MRD) is highly prognostic for relapse and overall survival (OS) in acute lymphoblastic leukemia (ALL), although many patients with apparent “MRD negativity” by standard assays still relapse. We evaluated the clinical impact of a highly sensitive next-generation …
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Completion Lymph Node Dissection or Observation for Melanoma Sentinel Lymph Node Metastases: A Decision Analysis
… We developed a Markov model to simulate the prognosis of hypothetical cohorts of patients with SLN metastases who underwent either immediate CLND or observation with delayed CLND if macroscopic disease developed. Model parameters were derived from published studies and included the likelihood of …
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Expression of Bax Predicts Outcome in Advanced Gastric Cancer Patients Treated With 5-fluorouracil and Platinum Palliative Chemotherapy
Purpose: The present study evaluated the predictive role of Bax, excision repair cross-complementation group 1 (ERCC1), and thymidylate synthase (TS) on clinical outcomes in patients with advanced gastric cancer treated with 5-fluorouracil (5-FU) and platinum palliative chemotherapy. Materials and …
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Sequential improvement in paediatric medulloblastoma outcomes in a low-and-middle-income country setting over three decades
… Cape Town, South Africa Methods: This was a retrospective study of 136 children with MB diagnosed between 1985 and 2015. Modified Chang criteria were used for risk stratification. The primary study objective was overall survival (OS), quantified by analysis of epidemiological, clinical and …
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The influence of cisplatin dose variations during concurrent weekly chemo-radiation in stage IIB cervical cancer at Groote Schuur Hospital
… effect of treatment and tumour factors on the overall survival (OS) of patients completing chemo-radiation (CRT) for stage IIB cervical cancer. Materials and methods: Retrospective audit of 228 patients with stage IIB cervical cancer treated between 1995 and 2010, who received CRT with at least …
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A retrospective review: long-term outcomes and predictors affecting long-term outcomes in osteosarcoma patients in the Groote Schuur Hospital patient population
… Predictive factors for long-term outcomes in osteosarcoma patients are still controversial. There is no literature available regarding these factors in a patient population in a developing country. Objectives: To determine the outcome of treatment of osteosarcoma patients treated at Groote …
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Treatment outcomes of Epstein-Barr virus associated nasopharyngeal carcinoma with three-dimensional conformal radiotherapy: A retrospective review
… The primary aim of the study was to determine overall survival (OS) of patients with EBV associated NPC treated over an 11-year period. Setting: Groote Schuur Hospital, between January 2003 and December 2013. Methods: This is a retrospective observational study. Medical records of all patients …
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Ependymal tumours in childhood: outcomes and prognostic factors
OBJECTIVES: To retrospectively review the patient demographics, disease profile and treatment outcomes of paediatric patients treated for ependymoma at our institution. STUDY DESIGN AND METHODS: 51 eligible patients were treated between 1980 and 2013. The median age at presentation was 6 years. The …
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Aspirin Use Is Associated with Improved Outcomes in Inflammatory Breast Cancer Patients
PURPOSE: Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and has a high propensity for distant metastases. Our previous data suggested that aspirin (ASA) use may be associated with reduced risk of distant metastases in aggressive BC; however, there are no reported …
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Does the Timing of Adjuvant Chemotherapy for Gastric Cancer Influence Patient Outcome?
PURPOSE: Although adjuvant chemotherapy is currently established as standard treatment in stage II/III gastric cancer, there is no report about the optimal timing of the initiation of chemotherapy. We investigated the effect of the interval between surgery and the start of chemotherapy on patient …
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Impact of no residual versus residual disease after hysterectomy for stage 1 cervical cancer on recurrence
… procedure (LEEP OR CKC) for histological diagnosis, followed by simple hysterectomy (29.6%), simple hysterectomy with lymphadenectomy (12.3%) or radical hysterectomy (58.2%). The prevalence of residual disease on hysterectomy specimen was 56.5%, versus no residual disease (43.5%). The overall …
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Advanced breast cancer: A retrospective review comparing two palliative radiotherapy protocols used at Groote Schuur Hospital between 2010 and 2013
Purpose: To retrospectively evaluate and compare the loco-regional progression free survival (PFS), overall survival (OS) and acute effects of the two breast palliative regimes used in patients with locally advanced or metastatic breast cancer between 2010 and 2013 in a single institution. Methods: …
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Predictive and Prognostic Value of Tumour-Infiltrating Lymphocytes in Women with Breast Cancer // Предиктивна и прогностична стойност на тумор-инфилтриращите лимфоцити при жени с рак на млечната жлеза
Ракът на гърдата (РГ) е най-честият злокачествен тумор при жените в света. По данни на Световната здравна организация (СЗО) в световен мащаб заболеваемостта от рак на гърдата е с около 2.1 млн. нови случаи, диагностицирани годишно, като в България годишно се регистрират около 4 000 нови случаи. В …
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Long-Term Survival In Metastatic Melanoma Patients With Leptomeningeal Disease Treated With Intrathecal Interleukin-2
… disease (LMD) have an extremely poor prognosis and a paucity of effective treatment options. We assessed the safety and efficacy of intrathecal interleukin-2 (IT IL-2) in metastatic melanoma patients with LMD.</p> <p><strong>METHODS:</strong> We reviewed the outcomes of 43 consecutive …
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Biliary atresia at Red Cross War Memorial Children's Hospital: A retrospective descriptive study reviewing the age of presentation, clinical course and outcome of infants presenting to RCWMCH with biliary atresia
… untreated it rapidly progresses to hepatic fibrosis and cirrhosis, with death occurring within 2 years. It is the leading cause of end-stage liver disease in the paediatric population and remains the most common indication for paediatric liver transplantation in South Africa. Objectives: Despite …
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Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
<p>Melanoma brain metastases (MBMs) are diagnosed in up to 60% of metastatic melanoma patients. Previous studies have identified clinical factors that correlate with overall survival (OS) after MBM diagnosis. However, molecular and immune features associated with OS are poorly understood. An …
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