Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 336 for “"Overall Survival"”.
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The overall survival and local control benefit of external beam radiation therapy for selected cancers
… 5-year local control (LC) and 2-year and 5-year overall survival (OS) benefits were investigated for gynaecological, head and neck, genitourinary, thyroid and brain cancers. Benefits were determined for each radiotherapy indication, for each cancer, in an optimal radiotherapy utilization decision …
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KRAS Codon 12 and Codon 13 Mutations in Relation to Overall Survival among Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
… of KRAS codon 12 and codon 13 mutations on the survival of CRC patients remains inconclusive. To address this, we conducted a systematic PubMed search and meta-analysis. Random-effects models were employed to quantify pooled association estimates and to investigate heterogeneity. Meta-regression …
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Impact of Cyclin-Dependent Kinase 4 and 6 Inhibitors on Chemotherapy Utilization and Overall Survival in Women with HR+/HER2– Metastatic Breast Cancer in the United States
Purpose: Delaying chemotherapy remains a vital goal in therapeutic management of HR+/HER2– metastatic breast cancer (MBC). However, recent reports continue to highlight substantially high chemotherapy utilization in earlier therapy lines. In this study, we explored the impact of cyclin-dependent …
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The incidence, management and outcomes of stage IIIB cervical cancer in a low- and middle-income setting
… hydronephrosis. Objectives: Determine the overall survival and disease-free survival of patients with stage IIIB cervical cancer with specific attention to those patients with hydronephrosis, determine the incidence of unilateral and bilateral hydronephrosis, determine how many patients …
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A demographic review of stage of presentation and survival rates of head and neck cancer patients in the Western Cape, South Africa
… to healthcare, more advanced cancers, and worse survival in rural and remote populations. This study investigates if significant disparities exist with regard to stage at presentation and overall survival of patients with head and neck cancer (HNC) between geographical areas within the Western …
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Pretreatment Serum CYFRA 21-1 Level Correlates Significantly with Survival of Cervical Cancer Patients: A Multivariate Analysis of 506 Cases
… independent prognostic factor for disease-free survival (OR, 3.110; [95% CI, 1.588-6.093], P=0.001) and overall survival (OR, 8.497; [95% CI, 1.797-40.184], P=0.007) in patients with squamous cell carcinoma, while pretreatment CYFRA 21-1(P=0.010) serum levels had a significant independent effect …
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A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital
… local control rate, loco-regional failure free survival, colostomy-free survival and overall survival. Design and Methods: The data was obtained from patient records of all patients with histologically confirmed anal squamous cell carcinoma seen and registered at the Department of Radiation …
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Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation
BACKGROUND: We compared response rates and survival after allogeneic bone marrow transplantation (BMT) or immunosuppressive treatment in severe aplastic anemia (SAA) and identified prognostic factors related with survival. METHODS: Medical data of SAA patients who treated with BMT or …
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Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
… showed that mutation of Y768 had no effect on overall survival. In addition, pharmacologic inhibition of Shp2 with II-B08 or PI3K with GDC-0941 in N51-FLT3-expressing cells and primary patient samples showed decreased proliferation. A possible mechanistic explanation for reduced proliferation …
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Perfil clínico, epidemiológico e sobrevida dos transplantados com células-tronco hematopoéticas
… possibility of cure or increase in disease-free survival. The objective of this study was to characterize the clinical and epidemiological profile of the patients who underwent HSCT at a referral service in the state of Rio Grande do Norte (RN), to estimate the overall survival of transplant …
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Body mass index and response to neoadjuvant chemotherapy in Korean breast cancer
… between pathological complete remission, survival and BMI. MATERIALS AND METHODS: This study is a retrospective study through chart review who received NAC at the Ajou University Hospital from 2001 to 2013. Total 217 patients were enrolled, of which 170 patients who performed MRI scan …
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Epidemiology of non-squamous non-small cell lung cancer in New Zealand: A focus on EGFR gene mutation
… burdens with persistent high incidence and poor survival. Treatment with Tyrosine Kinase Inhibitors (TKIs) that target Epidermal Growth Factor Receptor (EGFR) significantly improves disease outcomes for non-squamous Non-Small Cell Lung Cancer (NSCLC) patients with EGFR mutation. A better …
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Prognostic Significance of Xct Polymorphisms and Expression In Patients With Advanced Pancreatic Cancer Treated With Chemotherapy
… region (UTR) <em>xCT</em> SNP rs7674870 and overall survival (OS): Median survival time (MST) was 10.9 and 13.6 months, respectively, for the TT and TC/CC genotypes (p = 0.027). Stratified analysis showed the genotype effect was significant in patients receiving gemcitabine in combination …
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Surrogate endpoints of survival in metastatic carcinoma
… endpoint, in place of the direct endpoint of overall survival (OS) could theoretically shorten the duration of RCTs and minimise the exposure of patients to ineffective or toxic treatments (2, 3). This thesis examined the relationship between surrogate endpoints and OS in metastatic colorectal …
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Kasos adenokarcinomos diagnostinių ir prognostinių biožymenų paieška /
Survival rates from pancreatic cancer have remained stagnant for decades due to the heterogenic nature of the disease. This dissertation aimed to find a new advanced biomarker and evaluate its clinical capabilities, thus enabling more individualised pancreatic cancer management. Between 2013 and …
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Prognostic factors in women with stage IIIB cervical cancer
… and treatment outcome. Primary endpoints were overall survival, disease-free and pelvic recurrence-free survival rates.
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Ldoc1, A Novel Biomarker of Prognosis In Chronic Lymphocytic Leukemia
… cells have unmutated IGHV genes have a median survival of 8 years; those with mutated IGHV genes have a median survival of 25 years. To identify new prognostic biomarkers and molecular targets for therapy in untreated CLL patients, we reanalyzed the raw data from four published gene expression …
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Genetic Polymorphisms and the Treatment Outcome in Standard-Risk Pediatric Acute Lymphoblastic Leukemia
… ago, the disease was uniformly fatal with an Overall Survival (OS) rate < 5%. Modern-day, multi-drug chemotherapy is associated with an overall survival rate over 80%. Standard-risk ALL comprises the majority of ALL with an overall survival approaching 90%. Despite this success, children who …
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Quantitative Imaging For Precision Medicine In Head and Neck Cancer Patients
… enhanced magnetic resonance imaging (DCE-MRI), overall survival using computed tomography (CT)-based radiomics, and overall survival using positron emission tomography (PET)-based radiomics. From DCE-MRI, where T1-weighted images are serially acquired after injection of contrast, quantitative …
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EFFECTS OF LEPTIN ON ESTABLISHED GLIOBLASTOMA CELL LINES
… growth and recurrence resulting in increased overall survival and progression free survival while distress is associated with decreased overall survival. The cellular pathways activated by eustress were examined in glioblastoma cell lines; leading us to examine the use of β<sub>3</sub> …
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