Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"Ovarian tumors"”.
-
The Involvement of the Cyclooxygenase Enzymes in the Gallus Domesticus Model of Ovarian Cancer
… the cyclooxygenase (COX) enzymes are involved in ovarian carcinogenesis in the hen as a model for the human disease. The expression patterns of COX-1 and -2 mRNA and protein in normal hen ovaries and hen ovarian tumors were determined. COX-1 mRNA expression was significantly increased in ovarian …
-
Mapping the Landscape of Acquired Vulnerabilities in Ovarian Cancer
… to identify the genetic lesions associated with ovarian cancer have noted the striking diversity of mutations occurring in this disease. This genetic diversity has complicated the search for novel therapies. However, recent data has suggested that one commonality of ovarian tumors might be …
-
Ανοσοϊστοχημική μελέτη της έκφρασης των οιστρογονικών υποδοχέων στους όγκους των ωοθηκών με μονοκλωνικά αντισώματα (με την μέθοδο αβιντίνης-βιοτίνης)
… were localized in 35% of cystadenomy in 67% of tumors of borderline malignancy and in 66% of carcinomas; also in 67% of sex cord-stromal tumors, in 29% of germ cell tumors and in 33% of metastatic tumors, while they were not detected at all in ovarian cysts. We conclude that ER-positive ovarian …
-
The role of ERα in the uterus during embryo implantation and in the ovary during ovarian tumorigenesis
… action via ERalpha in uterine physiology and ovarian pathophysiology and is written in two parts. The first part is an investigation of ERalpha and its downstream target Hif2alpha in the uterus during embryo implantation. The later part of the dissertation discusses the role that ERalpha plays …
-
The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis.
… on cell migration and uPAR expression in ovarian cancer cell lines. We also analyzed the diagnostic and prognostic value of cleaved forms of the uPAR in plasma from patients with ovarian tumors. EGF stimulates cell migration by up-regulation of cell surface uPAR in ovarian cancer cells via …
-
Intrinsic subtypes and prognostic implications in epithelial ovarian cancer
Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. However, ovarian cancer is a …
-
Effects of Diabetes on Ovarian Cancer: Data Analysis and Modeling Study
<p>Ovarian cancer has one of the highest mortality rates of all gynecological cancers [13]. Further knowledge of risk factors for the growth of ovarian tumors would be beneficial in both the treatment and prevention of this type of cancer. Previous research has shown a positive correlation between …
-
The role of p27 phosphorylation in mediating atRA sensitivity of ovarian carcinoma cells
… has been shown to inhibit the growth of CAOV3 ovarian carcinoma cells. This results from arrest of the cell cycle during the G1 phase. G1 checkpoint is regulated by a multitude of molecules, including the retinoblastoma family of proteins, cyclin dependent kinases (Cdks), and cyclin dependent …
-
AN INVESTIGATION OF POTENTIAL MECHANISMS UNDERLYING CHEMOSUPPRESSIVE EFFECTS OF DIETARY FLAXSEED IN THE LAYING HEN MODEL OF OVARIAN CANCER
Epithelial ovarian cancer is the most lethal gynecologic malignancy, with a 5-year survival rate of less than 40%. This is due in part to a lack of early detection markers and lack of specific symptoms during early disease. The laying hen is the only accessible animal model which develops …
-
The Role of Cyclin E In Pkc Iota-Driven Early Ovarian Tumorigenesis
<p>Among the gynecologic malignancies, epithelial ovarian tumors are the leading cause of death. For the past few decades, the only treatment has involved surgical resection of the tumor and/or general chemotherapies. In an attempt to improve treatment options, we have shown that several oncogenes …
-
DNA methylation analysis and identification of a novel antisense transcript in the Peg3 imprinted domain
… hypermethylation in DNA derived from breast and ovarian tumors. Second, we identified an antisense transcript to ZIM2 (zinc finger imprinted gene 2) called ZIM2as in the human, chimpanzee, and orangutan. In non-primate mammals, the 5’ side of the Peg3 imprinted domain is bounded by a cluster of …
-
Indications and limitations of vNOTES for the surgical staging of early-stage ovarian cancer: a narrative literature review
… σε οριακούς όγκους των ωοθηκών (borderline ovarian tumors – BOTs) και σε εκτιμώμενο πρώιμο στάδιο επιθηλιακού καρκίνου των ωοθηκών (epithelial ovarian cancer – EOC). Μέθοδοι: Πραγματοποιήθηκε βιβλιογραφική ανασκόπηση με στόχο την αξιολόγηση της δυνατότητας χρήσης της συγκεκριμένης …
-
Tumor-penetrating delivery of small interfering RNA therapeutics
… protein transduction domains to direct siRNA to tumors in vivo. Second, we utilized this delivery system to bridge the gap between cancer genomic discovery and in vivo target validation. Comprehensive analysis of ovarian cancer genomes identified candidate targets that are undruggable by …
-
Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
<p>High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer. Angiogenesis is a vital function for both wound healing and oxygen homeostasis and is one of the hallmarks of cancer in solid tumors. To …
-
Estrogen in ovarian cancer cell metastasis
Benign ovarian tumors and majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and …
-
The role of Mullerian differentiation in epithelial ovarian carcinogenesis
Ovarian cancer is a fatal disease because of the lack of symptoms and markers for early detection. Most ovarian neoplasms resemble and are classified according to the complex characteristics of Mullerian duct epithelia. We tested the hypothesis that Mullerian epithelial characteristics influence …
-
MUTANT P53 AS A THERAPEUTIC TARGET IN CANCER
… and inactivated in half of sporadic human tumors. Additionally, individuals who harbor germline TP53 mutations are at greater risk for developing spontaneous cancer. Within the spectrum of germline TP53 mutations are hypomorphic variants, which are partially inactivated with defective tumor …
-
Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance. Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal metastasis. TG2 is a multifunctional protein which catalyzes Ca2+-dependent cross-linking of …
-
A New Immunoassay for Quantification of a Novel Cancer Antigen in Serum and Immunostaining of Carcinoma Tissues and Cultured Cells Revealing the Antigenic Cellular Location.
… those with a family history of cancer (n = 97). Ovarian, breast, colon carcinoma tissues and their normal counterparts and cultured ovarian and prostatic carcinoma cells were subjected to immunofluorescence using IgY antibodies and goat anti-chicken fluorescent secondary antibodies. Basic imaging …
Page 1 of 2