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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 21 for “"Ovarian tumor"”.

  1. Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis

    Zhao, Guannan2021

    <p>Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and …

    tenn-hsc Repository record

  2. The impact of cholesterol and its metabolites on the ovarian tumor microenvironment and cancer progression

    He, SisiUniversity of Illinois at Urbana-Champaign2020

    … therapeutic or lifestyle strategies for treating ovarian cancer due to its high recurrence and mortality rate. In this regard, we and others have found that cholesterol appears to be clinically important for ovarian cancer survival, highlighting it and its metabolism as potential therapeutic …

    uiuc Repository record

  3. From Naturally Occurring Tumor Immunity to Supernatural T Cells: Isolation and Characterization of a Murine T Cell Receptor Specific for Human Breast and Ovarian Tumor Antigen Cdr2

    Santomasso, Bianca D

    … a protein called cdr2 in their breast and ovarian carcinomas, and thus provide an innovative starting point for understanding how to harness the immune system to fight cancer. We previously demonstrated cdr2-specific cytotoxic T lymphocytes (CTL) in the peripheral blood of HLA-A2.1+ PCD …

    rockefeller Repository record

  4. Effects of Diabetes on Ovarian Cancer: Data Analysis and Modeling Study

    Belay, Claire2020

    <p>Ovarian cancer has one of the highest mortality rates of all gynecological cancers [13]. Further knowledge of risk factors for the growth of ovarian tumors would be beneficial in both the treatment and prevention of this type of cancer. Previous research has shown a positive correlation between …

    columbus-state Repository record

  5. Cancer Associated Fibroblast Derived Angiogenic Factor Mfap5 In Ovarian Cancer Progression

    LEUNG, SZE LEE CECILIA2019

    <p>Advanced stage ovarian cancer is the most lethal gynecologic malignancy. No major improvement on patient survival has been achieved in the past decade. Therefore, identification of predictive or prognostic markers and further understanding of the molecular mechanisms in ovarian cancer …

    uthsc Repository record

  6. MUTANT P53 AS A THERAPEUTIC TARGET IN CANCER

    Foster, Maya, Janae2026

    … TP53, the gene that encodes the prominent tumor suppressor protein p53, is mutated and inactivated in half of sporadic human tumors. Additionally, individuals who harbor germline TP53 mutations are at greater risk for developing spontaneous cancer. Within the spectrum of germline TP53 …

    penn Repository record

  7. The Development of a Novel Tumor -Specific MRI Contrast Agent Targeting the High Affinity Folate Receptor: In Vitro and in Vivo Specificity, Toxicity, and Biodistribution

    Konda, Sheela DeviUniversity of Illinois at Urbana-Champaign2002

    … receptor (hFR) overexpressed on more than 80% of ovarian tumors. We tested the hypothesis that folate-dendrimers can specifically image tumors expressing the hFR with MRI. Conjugating folate to dendrimers results in specific binding of these macromolecules to cells expressing the hFR and enables …

    uiuc Repository record

  8. LOCOREGIONAL DELIVERY OF UNMETHYLATED CPG-OLIGODEOXYNUCLEOTIDES TO CANCER THERAPY: PRECLINICAL STUDIES

    M. SommarivaUniversità degli Studi di Milano2010

    Tumor cell growth, even in advanced stages of ovarian cancer, is nearly always restricted to the peritoneal cavity, therefore repeated intraperitoneal injections of CpG-ODN recruiting and activating innate effector cells throughout the abdominal cavity to the tumor site might control tumor cell …

    milano Repository record

  9. THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES

    Dikshit, Anushka

    Ovarian cancer (OvCa) is the most fatal gynecological malignancy, with over 21,290 new cases diagnosed in 2015. The 5 year survival rate for patients diagnosed at Stage IV is 17% in the United States. It has been reported that estrogen (E2) can promote metastasis of ovarian tumor cells through its …

    siu-theses Repository record

  10. Biophysical Characterization of the vOTU Proteases from the CCHF and Dugbe Nairoviruses

    Capodagli, Glenn C.2001

    … specificity of the viral homolog of the ovarian tumor domain protease superfamily (vOTU) from nairoviruses, and the structural reasons for their specificities. The vOTU from the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) has been implicated in the down-regulation of the innate immune …

    denver Repository record

  11. Estrogen in ovarian cancer cell metastasis

    Park, Se HyungUniversity of British Columbia2008

    Benign ovarian tumors and majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and …

    ubc Repository record

  12. The role of ERα in the uterus during embryo implantation and in the ovary during ovarian tumorigenesis

    Laws, Mary J.University of Illinois at Urbana-Champaign2011

    … action via ERalpha in uterine physiology and ovarian pathophysiology and is written in two parts. The first part is an investigation of ERalpha and its downstream target Hif2alpha in the uterus during embryo implantation. The later part of the dissertation discusses the role that ERalpha plays …

    uiuc Repository record

  13. Epitelinio kiaušidžių vėžio predikcinių imuninių žymenų paieška /

    Šalčiūnienė, Greta,Institutional Repository of Vilnius University2017

    … for Predictive Immune Biomarkers of Epithelial Ovarian Cancer The aim of the study: To identify predictive immune biomarkers of chemotherapy resistance in the epithelial ovarian tumor microenvironment and peripheral blood, and to investigate the relationships among them. Objectives: to evaluate …

    vilnius Repository record

  14. The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis.

    Henic, EmirDepartment of Obstetrics and Gynecology, Lund University2008

    … on cell migration and uPAR expression in ovarian cancer cell lines. We also analyzed the diagnostic and prognostic value of cleaved forms of the uPAR in plasma from patients with ovarian tumors. EGF stimulates cell migration by up-regulation of cell surface uPAR in ovarian cancer cells via …

    lund Repository record

  15. Targeting mdr1 and endocrine therapy-­resistant cancers through estrogen receptor

    Zheng, XiaobinUniversity of Illinois at Urbana-Champaign2017

    … with the development of aggressive breast and ovarian cancers. Endoplasmic reticulum (EnR) stress signaling cascade, the unfolded protein response (UPR), has documented in various human cancers and diseases. However, the precise roles of UPR signaling in development of hormone-dependent …

    uiuc Repository record

  16. Circumventing Cisplatin Resistance In Ovarian Cancers Through Reactivation of P53 By Non-Cross-Resistant Platinum Analogs

    Martinez-Rivera, Michelle2017

    … <p><strong>CIRCUMVENTING CISPLATIN RESISTANCE IN OVARIAN CANCERS THROUGH REACTIVATION OF P53 BY NON-CROSS-RESISTANT PLATINUM ANALOGS</strong></p> <p><strong>Michelle Martinez-Rivera, B.S.</strong></p> <p><strong>Advisory Professor: Zahid H. Siddik, Ph.D.</strong></p> <p>Cisplatin (cis-Pt), an …

    uthsc Repository record

  17. Profiling mucinous ovarian cancer and comparisons with tumours of the gastro-intestinal tract: identification of markers for diagnosis, prognosis, and treatment targets.

    Meagher, Nicki ; https://orcid.org/0000-0001-9134-2118UNSW, Sydney2022

    Mucinous Ovarian Carcinoma (MOC) is a rare histological subtype, comprising 3-4% of all epithelial ovarian cancers. The majority (~80%) of patients are diagnosed at early stage, International Federation of Gynecology and Obstetrics (FIGO I/II), with a good prognosis after primary surgery. The key …

    unsw Repository record

  18. In vitro Expression of Human Zona Pellucida Protein 3

    Chen, Chih-Wei2019

    … protein (47 kDa). Stable transfection of a human ovarian tumor cell line, PA-1, was produced by introduction of the hZP3/pREP4 expression vector construct using the calcium phosphate precipitation method. Approximately 200 single colonies of the stable-transfected cells were isolated by the …

    odu Repository record

  19. ASSESSMENT OF VARIABLE-DOSE SCHEDULING EFFECTS ON THE KINETICS AND HOMING OF ANTIGEN-SPECIFIC T CELLS IN CANCER VIA OPTICAL IMAGING

    Yarovoy, Iven2018

    Ovarian Epithelial cancer is the most prevalent form of ovarian cancer overall. It is the leading cause of gynecologic cancer mortality, partly due to its lack of distinctive symptoms. The mainstay for treatment for metastatic ovarian cancer has largely been chemotherapeutics, but recently …

    buffalo Repository record

  20. Species Preference of Viral Deubiquitinating Proteases Toward ISG15 Through Structural and Enzymatic Characterization

    Deaton, Michelle Kay2016

    <p>Proteases from the Ovarian Tumor domain (OTU) superfamily of deubiquitinating enzymes (DUBs) are expressed by a range of RNA viruses. Viral OTUs (vOTUs) are found in nairoviruses such as Crimean Congo Hemorrhagic Fever virus (CCHFV), Nairobi sheep disease virus (NSDV), the Erve virus (ERVEV), …

    denver Repository record

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