Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Ovarian carcinoma"”.
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The Role of Platelets In Ovarian Carcinoma
… of paraneoplastic thrombocytosis associated with ovarian carcinoma remains unknown and were the focus of the current study. Following IRB approval, patient data were collected on 619 patients from 4 U.S. centers and used to test associations between platelet count at initial diagnosis, …
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Platelets and Anti-Angiogenic Resistance In Ovarian Carcinoma
… found to increase at the time of diagnosis of ovarian cancer recurrence in a pattern comparable to CA-125. Platelet co-culture increased proliferation, increased migration, and decreased apoptosis in all cell lines tested. RNA interference implicated platelet derived growth factor alpha …
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X chromosome studies and breast and ovarian carcinoma
… X content have been associated with breast and ovarian cancer. Partial or complete reactivation of the inactive X in females may be a step in breast and ovarian cancer progression, leading to overexpression of some tumour enhancing gene. Markers of an X reactivation event were examined: X gene …
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Evaluation of novel prognostic factors In ovarian carcinoma
… was collected from 283 randomly chosen ovarian cancer cases from at the Saskatoon Cancer Centre between the years 1983-1995. The data was evaluated for its significance in predicting survival and relapse free survival (RFS) using univariate and multivariate analysis. Several clinical …
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Augmented Radiology in High Grade Serous Ovarian Carcinoma
… topics will be considered in the context of ovarian cancer, a complex, multi-site disease which is frequently diagnosed at late stage, and for which limited improvement in survival outcomes has been made in recent decades. Chapter 3 considers the clinical utility of a newly developed AI-based …
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Oncogenic Signaling Pathways Activated by Lysophosphatidic Acid (LPA) in Ovarian Carcinoma
Ovarian cancer is currently the most fatal gynecologic cancer and the fifth leading cause of fatal cancer in women overall. As compared to the better-characterized malignancies, such as such as prostate, breast and colorectal cancers, there have been no major changes in methods of detection or …
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The role of p27 phosphorylation in mediating atRA sensitivity of ovarian carcinoma cells
… has been shown to inhibit the growth of CAOV3 ovarian carcinoma cells. This results from arrest of the cell cycle during the G1 phase. G1 checkpoint is regulated by a multitude of molecules, including the retinoblastoma family of proteins, cyclin dependent kinases (Cdks), and cyclin dependent …
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… remains a critical barrier to effective ovarian cancer therapy, necessitating a deeper understanding of the cellular and metabolic changes that drive platinum resistance. Here, we dissect the interplay between platinum-induced genotoxic stress, type-I protein arginine …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… of immune cell abundance in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave imprints of copy-number aberrations (CNA) …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
About 70% of patients with ovarian cancer (OC) are diagnosed at an advanced stage (III-IV), with associated poor prognosis, even after chemotherapeutic interventions (mostly platinum taxane-based), leading to poor survival rates. The current biomarkers available in the clinic are not enough for …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… showed that BRCA-deficient high grade serous ovarian carcinoma (HGSOC) had increased tumor infiltrating lymphocytes (TILs) compared to BRCA-wildtype (WT). To better understand the underlying immune mechanism in these tumors, a preliminary transcriptome analysis was performed on a set of …
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Comparison of Survival between Patients with Serous Fallopian Tube carcinoma and Serous Adenocarcinoma of the Ovary
Primary fallopian tube carcinoma is rare, about 0.14-1.8 % prevalence of the total female carcinoma that histologically and clinically resembles epithelial ovarian carcinoma. Because fallopian tube lies close by ovary, stage and treatment of fallopian tube carcinoma were similar that of ovarian …
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A Review of Women with Epithelial Ovarian Carcinoma in a Middle-Income setting: Groote Schuur Hospital, Cape Town, South Africa: Demographics, Treatment and Outcomes of Patients between 2005 and 2015
… In 2020 there were 313 959 new cases of Ovarian carcinoma worldwide.1 It is one of the most challenging female gynaecological cancers to manage with a poor prognosis for latestage disease and high recurrence rates. Ovarian Carcinoma ranks 8th amongst new cancer cases in women and accounts …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
<p> <p>Background: High grade serous carcinoma whether ovarian, tubal or primary peritoneal, continues to be the most lethal gynecologic malignancy in the USA. Although combination chemotherapy and aggressive surgical resection has improved survival in the past decade the majority of patients still …
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Studies on the synergic activity of a three-drug cocktail active against cisplatin-resistant human leukemia and carcinoma cells
… CEM cells, wild type and CDDP-resistant human ovarian carcinoma A2780 cells, and ex vivo cultures of human peripheral blood lymphocytes from healthy donors, were used as cell models to characterize the cytotoxic activity of both binary and ternary drug combinations. Experimental Design (ED) and …
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Expression and role of the extracellular matrix protein tenascin in ovarian cancer
… of malignant tumours. The expression of TN in ovarian cancer has not previously been investigated. The aims of the project were therefore to (i) define the expression of TN in ovarian cancer, (ii) examine factors controlling its production and (iii) explore the functionality of the protein. …
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Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
<p>High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer. Angiogenesis is a vital function for both wound healing and oxygen homeostasis and is one of the hallmarks of cancer in solid tumors. To …
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Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis
… along with their activity against A2780 human ovarian carcinoma and WHCO1 oesophageal cancer cell-lines.
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Arsenic trioxide in ovarian cancer
… responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance in ovarian cancer cells were investigated. It was found that As2O3 treatment caused both apoptosis induction and …
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