Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 860 for “"Ovarian"”.
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Characterization of Residual Ovarian Tissue in Mice following 4-vinylcyclohexene Diepoxide-induced Ovarian Failure
… with disorders such as osteoporosis and ovarian cancer. It is unclear whether the postmenopausal ovary retains steroidogenic capacity and how it can impact the development of these disorders. The present studies used the VCD-treated follicle-depleted mouse model of menopause to test the …
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Arsenic trioxide in ovarian cancer
… responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance in ovarian cancer cells were investigated. It was found that As2O3 treatment caused both apoptosis induction and …
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BMP9 Signalling in Ovarian Cancer
Ovarian Cancer is the 5th most common cause of cancer death in women and the second most common gynaecological cancer in the UK. Worldwide, around 152,000 women were estimated to have died from ovarian cancer in 2012. Survival rates for women with epithelial ovarian cancer have not significantly …
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An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… there are over 190,000 new reported cases of ovarian cancers per annum. This comprises 3% to 4% of all cancers in women. Ovarian cancer is one of the leading causes of deaths in women. Ovarian cancer is the second most diagnosed gynaecological malignancy and over all the fifth cause leading to …
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OVARIAN TISSUE BANKING IN ANIMAL MODELS
Ovarian tissue preservation offers limitless opportunity of fertility insurance for all ages and at any state of reproductive cycle in addition to multiple restoration options that can rekindle both reproductive and endocrine functions of the gonad. Vitrification has been argued as a superior …
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The mechanism of ovarian cancer chemoresistance
Ovarian cancer (OC) is the leading cause of female reproductive tract cancer mortality in the world. Although cytoreductive surgery followed by platinum/taxane acts a standard therapy and contributes to a high initial response rate, most patients will ultimately develop tumour recurrence and …
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Estrogen in ovarian cancer cell metastasis
Benign ovarian tumors and majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and …
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Biochemistry of ovarian cells in vitro
… supported by in vivo studies using ewes bearing ovarian autotransplants since it was found that, just as in vitro, simultaneous administration of PGE₂ would antagonise the luteolytic action of PGF₂α. Corpora lutea were infused with either PGF₂α, PGE₂ PGE₂α + PGE₂ or saline on Day 10 of the cycle. …
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Studies of the mammalian ovarian endothelin system
… In situ hybridization was used to determine the ovarian compartment that synthesizes ECE-1. ECE-1 mRNA was detected in granulosa cells of large (10 mm) and medium (3 mm) antral follicles. This study, in conjunction with previous studies suggests a novel autocrine role of ET-1 as a possible local …
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The Role of Platelets In Ovarian Carcinoma
… of paraneoplastic thrombocytosis associated with ovarian carcinoma remains unknown and were the focus of the current study. Following IRB approval, patient data were collected on 619 patients from 4 U.S. centers and used to test associations between platelet count at initial diagnosis, …
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The Role of Gdf15 In Ovarian Cancer
… diseases, diabetes, and rheumatoid arthritis. In ovarian cancer, high GDF15 serum levels correspond to poor survival. It has further been shown to be expressed at higher levels in serum in ovarian cancer patients post-chemotherapy than pre-chemotherapy.</p> <p>The overall 5-year survival for …
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Ovarian cancer serum biomarker discovery using proteomics
Ovarian cancer is a lethal gynaecological malignancy which is known as the silent killer. It has a poor prognosis due to the lack of major symptoms in early stage disease and hence its late detection. Cancer antigen-125, the most widely used biomarker for ovarian cancer detection, lacks appropriate …
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Cytogenetic studies of ovarian and endometrial malignancies
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Modeling Epithelial Ovarian Cancer In The Mouse
For over five decades epithelial ovarian cancer (EOC) is identified as the leading cause of death from gynecological malignancies in the USA. Unfortunately, due to latent progression of EOC and lack of accurate animal models studies of this disease's pathogenesis have been challenging. Not …
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ING1 Impacts Ovarian Cancer by Altering EMT
… well as its clinical implication in epithelial ovarian cancer. Our analyses revealed that ING1 epigenetically regulates the transcription machinery of the EMT program through binding to the promoter region of Twist1, the critical gene encoding transcription factor (TF) that induce EMT. …
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Lateral Distribution and Recurrence of Ovarian Endometrioma
… the lateral distribution and recurrence of ovarian endometrioma. MATERIALS AND METHODS: The 371 patients who were diagnosed as ovarian endometrioma through pathology in Ajou University Hospital during from May 1994 to Apr. 2007 were retrospectively studied. The characteristics of ovarian …
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Effects of Hyperadrenalism on Bovine Ovarian Function
Effects of hyperadrenalism on bovine ovarian function were studied by using 25 intact heifers treated with ACTH or saline (S) and 33 adrenalectomized (ADRX) heifers treated with ACTH, hydrocortisone succinate (HS), progesterone (P) or S and bovine pituitary cells in culture. All ADRX animals were …
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