Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Ototoxicity"”.
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Ototoxicity Monitoring using Automated Extended High-Frequency Audiometry and the Sensitive Range of Ototoxicity in Patients with MDR-TB
… permanent hearing loss and/or balance disorders. Ototoxicity monitoring aims to reduce this burden by preventing or minimising the damage caused by ototoxic treatment as it can progress and worsen speech perception difficulties. However, the proposed test battery for ototoxicity monitoring is …
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TARGETING COCHLEAR INFLAMMATION FOR THE TREATMENT OF CISPLATIN OTOTOXICITY
… One of the forms of hearing loss, known as ototoxicity, refers to damage to the ear (-oto) due to xenobiotics. Cisplatin is the most widely used antineoplastic agent in the treatment of various solid tumors. Cisplatin toxicity can lead to severe effects on the kidneys, nervous system and …
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The efficacy of strategies used to minimise and prevent cisplatin ototoxicity in patients
… The study also sought to compare different ototoxicity grading criteria; namely the National Cancer Institute Common Terminology Criteria for Adverse Events Version 4 (CTCAE v4) and TUNE criteria, with respect to early identification of changes in the patient’s hearing thresholds following …
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Investigating the genetic basis of cisplatin-induced ototoxicity in adult South African patients
… patients. A prevalent reaction to cisplatin is ototoxicity, or drug-induced hearing loss, which occurs when the drug accumulates in and damages cells of the inner ear, leading to permanent and progressive hearing impairment. In this investigation, two approaches were employed to explore the role …
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Efficacy of N-acetylcysteine on Prevention and Amelioration of Cisplatin-induced Ototoxicity: A Systematic Literature Review
… NAC efficacy in prevention of cisplatin-induced ototoxicity.</p> <p>Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City University of New York was conducted to identify relevant studies for analysis. The levels of evidence were applied …
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Effectiveness of different medical interventions implemented when a change in hearing status is detected during ototoxicity monitoring
… for RR/MDR-TB patients, are associated with ototoxicity (cochlear or vestibular). Aminoglycoside-induced cochleotoxicity is characterised by permanent, bilateral, highfrequency (HF) sensorineural hearing loss (SNHL). The impact of hearing loss (HL) due to aminoglycoside-induced …
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Factors that influence the utilisation of ototoxicity monitoring services for patients on treatment for drug-resistant tuberculosis
… which are known to cause hearing loss. Ototoxicity monitoring services are often provided to patients undergoing treatment for MDR-TB for early detection of ototoxic hearing loss to facilitate alerting the patients and relevant medical staff about the presence and progression of any …
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Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication
… kHz. These results show that cisplatin induces ototoxicity including hearing loss as well as down-regulation of GJIC and inhibition of Cxs in auditory cells. EGb prevents hearing loss in cisplatin-treated rats by inhibiting down-regulation of Cx expression and GJIC. The disturbance of GJIC or Cx …
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Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
… incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of MDR-TB patients; To determine …
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The Role of Connexin43 and Gap Junctional Intercellular Communication in the Apoptotic Process of Auditory Cells
… with cisplatin are exposed to high risk of ototoxicity such as hearing loss or dizziness. It has been reported that ototoxicity occurs in about 75-100 % of patients treated with cisplatin and shows irreversible, cumulative and bilateral characteristics. However, cisplatin-induced ototoxic …
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The Distribution of Innate Antioxidant Enzymes in Rat Cochleas
… aminoglycosides is limited by the potential for ototoxicity and nephrotoxicity. In the cases of aminoglycosides’ ototoxicity, the damage of outer hair cells (OHCs) progresses in a base-to-apex gradient. Although the mechanism of GM ototoxicity has not been identified with certainty, the …
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Profound childhood deafness in South Africa : a clinical and molecular genetic approach
… dysplasia (AD CMD), familial streptomycin ototoxicity (FSO) and a private syndrome comprising deafness, microtia and facial palsy (DMF). Sclerosteosis is an autosomal recessive disorder of bone overgrowth with a high gene frequency among the Afrikaner population of South Africa. Gene …
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A fully implantable intracochlear drug delivery device : development and characterization
… inner ear disease and cisplatin-induced ototoxicity. Current efforts include ongoing refinement of the design, miniaturization of components, and testing in an in vivo guinea pig model. This thesis focuses on the interactions between the device and inner ear, including the investigation …
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The Role of the Mitogen Activated Protein Kinase Pathway in Cisplatin and Noise-Induced Hearing Loss
… loss in a translational mouse model of cisplatin ototoxicity while dabrafenib, trametinib, and tizaterkib, an ERK1/2 inhibitor, protected from noise-induced hearing loss. Additionally, dabrafenib was shown to be protective from another side effect of cisplatin, nephrotoxicity. Inhibiting the MAPK …
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Defining the cellular and molecular mechanism of maternally inherited hearing loss
… with a predisposition to aminoglycoside ototoxicity and maternally inherited non-syndromic deafness. However, the reasons for the highly variable penetrance of the associated hearing loss have not yet been fully resolved. Aminoglycosides are a recognised modifier factor of the hearing …
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Distortion product otoacoustic emissions: towards reliable and valid early identification and monitoring of hearing in adults receiving ototoxic medication
… Hz and 1.20 for f2 < 5000 Hz when monitoring for ototoxicity, to assist with early identification of outer hair cell damage, in conjunction with high frequency pure tone audiometry. This finding needs to be confirmed in a larger sample of participants with MDR-TB receiving ototoxic medication.
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ORAL ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE (EGCG) IS A POTENTIAL THERAPEUTIC FOR CISPLATIN-INDUCED HEARING LOSS
Cisplatin is a commonly used chemotherapeutic agent for multiple solid tumors. However, cisplatin-induced neurotoxicity, nephrotoxicity and hearing loss hamper its use in clinical setting. Although, neurotoxicity and nephrotoxicity can be prevented, there is no cure for cisplatin-induced hearing …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
Aminoglycoside antibiotics remain essential for treatment of severe Gram-negative bacterial infections, yet their clinical use is limited by the risk of irreversible sensorineural hearing loss. Many signaling pathways change during ototoxic injury, but transcriptional change alone does not …
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
… an effective protective agent against cisplatin ototoxicity These data suggest that localized delivery of CB2 agonists should be studied in human for protection against hearing loss.
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Vestibular functioning and pathology in adults with HIV/AIDS : a comparative study
… causing vertigo, dizziness or disequilibrium. Ototoxicity may also be related to vestibular dysfunction, due to the ototoxic nature of certain ARV medications. HIV/AIDS influence not only the vestibulo-ocular reflex, but also the vestibulocollic reflex pathways. Primary health care providers …
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