Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Otic"”.
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Effects of dietary supplementation with Bacillus spp. on immune response, intestinal health outcomes, and the nasal, otic, and fecal microbiota of healthy adult dogs
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Generation of human inner ear organoids from pluripotent stem cells and an organ-on-chip platform
… of the microenvironmental niche in which human otic progenitors emerge and develop is a key barrier to progress. This project builds on our previous discovery of a 3D culture system that uses hiPSCs to generate inner ear (otic) organoid containing sensory epithelium, neurons, and mesenchymal …
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Characterization of Agrin Function in Chicken and Zebrafish Embryogenesis.
… of the midbrain-hindbrain boundary, eye, and otic vesicles. Morphants subsequently develop paralysis, and die at larvae stages. Knockdown of agrin in zebrafish strikingly resembles phenotypes of zebrafish FGF-related mutants, such as disruption of the MHB, optic and otic vesicles during …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… originates from an ectodermal thickening, the otic placode, which invaginates and forms the otic vesicle. The otic placode gives rise to the hearing (cochlea) and balance (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular ganglia. …
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Organophosphorus Pesticide Exposure Effects on Neurobehavioral Development of Zebrafish and Characterization of Developmental Switch Between Two Cation-chloride Cotransporters (zfnkcc1 and zfkcc2)
… tissue, but appears concentrated to the otic vesicle at 3 dpf. Using double in situ hybridization, we investigated the nature of the developmental switch from zfnkcc1 to zfkcc2 by looking at regions where there was an interaction between both genes' expression patterns in the developing …
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Reinvestigation of the Auriculotemporal Nerve
… and in its means of communicating with the otic(sic) ganglion. Among the many accounts of the auriculotemporal nerve consulted, there is found a sterotyped description of the nerve indicating that it is formed by two immediately adjacent roots which tightly enclose the middle meningeal …
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A functional and therapeutic investigation of ciliopathy proteins and ciliopathies
… phenotypes, such as laterality randomisation, otic vesicle anomalies, and kidney cysts. Administration of two drugs, Rapamycin and Roscovitine, were sufficient to rescue formation of kidney cysts and restore the filterative capacity of the kidney. This paves the way for studies in mouse models …
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Exotic States in Quarkonium Physics: Effective Theories of Heavy Mesonic Molecules and an AdS/QCD Model of Hybrid Quarkonium
… dualities to study the physics of ex-</p><p>otic quarkonium states, that is bound states containing a heavy quark-antiquark pair</p><p>which nevertheless cannot be be understood working only with the standard quark</p><p>model of hadrons. Candidates for such states, long speculated to exist, …
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Promotion of Hair Cell Fate by Atoh1 and MicroRNA-183 Family
… stem cells (mESCs) and immortalized multipotent otic progenitor (iMOP) cells. Our lab has previously developed an array of plasmid vectors expressing miR-183 family alone or in combination with Atoh1, along with red fluorescent protein (RFP) from a single transcript. HEK293 cells were used to …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
Aminoglycoside antibiotics remain essential for treatment of severe Gram-negative bacterial infections, yet their clinical use is limited by the risk of irreversible sensorineural hearing loss. Many signaling pathways change during ototoxic injury, but transcriptional change alone does not …
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Development of an Optogenetic Tool for Targeted Sensory Hair Cell Ablation in Zebrafish
Mechanosensory hair cells convert mechanical information into neuronal signals. Mutations in the genes required for hair cell function cause deafness and lead to the degeneration of sensory hair cells. Mammals are unable to regenerate these cells, leading to the permanent loss of hair cells. …