Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 76 for “"Other Pharmacy and Pharmaceutical Sciences"”.
-
The Relationship Between Psychological Contract Breach, Professional Identity, And Organizational Citizenship Behaviors: An Equity Sensitivity Perspective
… contract breach, equity sensitivity, and identity salience on an important employee outcome, namely organizational citizenship behaviors. Second, the research explored the effects that discipline and pharmacist status have on organizational citizenship behaviors. More precisely, the …
-
Modifying Tryptophan and Indole-Derived Compounds Using Engineered Indole Prenyltransferase Enzymes
… from natural pyrophosphate donors to tryptophan and other indole-derived small molecules. Prenylation alters the structure of small molecules, enhances their hydrophobicity, and subsequently alters their interaction with cell membranes and receptors. Prenylation of small molecules has been …
-
Design and Synthesis of a Novel Neuroprotective Brain-Targeting Amylin Receptor Antagonist
… against amyloid beta (Aβ)-induced cell death and toxicity. Additionally, AC253 has been shown to improve spatial memory in mouse models of Alzheimer’s disease (AD). Screening of short overlapping fragments (12-mer) of AC253 showed that N-terminal residues were responsible for high affinity …
-
Artificial Intelligence Applications for Optimizing Population and Clinical Drug Decision-Making Processes
… an artificial intelligence chatbot, in the pharmacy field, specifically the capability of ChatGPT4 to extract and analyze FDA drug information, conduct a cost-effectiveness analysis of two antibiotics, and identify and classify adverse drugs events (ADE). We compare the results of ChatGPT4 …
-
Influence of Human and Viral IL-6 on KSHV Infection in Human Tonsil Lymphocytes
… Castleman Disease, Primary Effusion Lymphoma, and the newly-identified inflammatory syndrome designated KICS. Despite proven connections to lymphoproliferative disorders, little is known about how KSHV invades the human immune system or the early events governing infection in B lymphocytes. …
-
PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… to activation of synovial resident macrophages and downstream production of interleukin-1b (IL-1b). Xanthine oxidase (XO) catalyzes purines into uric acid (UA) and reactive oxygen species (ROS) that activate NLRP3 inflammasome. Protein phosphatase-2A (PP2A) may be involved in regulating …
-
Content and Activity of Cytochrome P450 3A in Rat Brain Microsomes and Mitochondria
… contribution of CYP3A in brain microsomes and mitochondria is crucial to designing appropriate therapeutic strategies and preventing toxicities. Until recently, there has been limited data reported in the literature with respect to CYP3A activity and its expression in the brain tissue. The …
-
Investigating Hybrid Cyclic/Linear and Linear Peptides as Vehicles for Nucleic Acid Delivery
<p>Small interfering RNA (siRNA) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated Protein 9 (Cas9) are advanced biotechnological approaches that have been able to temporarily downregulate gene expression through post-transcription RNA interference or …
-
Role of Macrophages in Ocular Surface Fibrosis
… could trigger macrophage activation and polarization and whether macrophages could cause the transdifferentiation of ocular surface fibroblasts into myofibroblasts, thus contributing to oGVHD-associated fibrosis.</p> <p>Bone marrow cells were cultured in M-CSF to obtain M0 …
-
Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… retinopathy, cataract, glaucoma, papillopathy, and ocular surface disease. Ocular surface abnormalities in patients of diabetes mullites include impairment of corneal epithelial barrier function, conjunctival defects, increased incidence of corneal and conjunctival infections and higher …
-
Role of Protein Phosphatase-2A in Regulating Monocyte Activation by Soluble and Crystalline Uric Acid in Gout
… resulting in downstream expression and production of interleukin-1 beta (IL-1β) and chemokines. The activation of monocytes by MSU crystals involves the priming of monocytes with danger signals e.g. lipopolysaccharide (LPS) or soluble uric acid (UA), crystal phagocytosis and …
-
Identification of Molecules by Spectral Imaging
… to identify/quantify the exact location and amount of the molecules. It facilitates the identification of materials and studying their properties through analyzing the way they interact with light. The study of light interaction with elements is called spectroscopy; spectroscopy examines …
-
The Use of Spectral Imaging to Reveal Inorganics and Organics Identity in The Biological Samples
… is used to identify the exact location and quantify the number of molecules in the spectral imaging system. It aids in identifying materials and studying their quantities by examining how they interact with light. A traditional spectrometer provides spectrum information of chemical …
-
Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… (PEL), multicentric Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). Existing research reveals that KSHV has developed numerous strategies to alter host cytokine signaling activities to facilitate viral persistence and escape host immune surveillance.</p> <p>Despite …
-
Design, Synthesis, and Evaluation of N-Methylated H2R2W4
<p>Antimicrobial peptides (AMPs) are potential candidates for developing antibiotics against multidrug-resistant bacteria. We have recently developed a potent cyclic AMP containing histidine (H), arginine (R), and tryptophan (W) residues named [H<sub>2</sub>R<sub>2</sub>W<sub>4</sub>]. This peptide …
-
Targeting Primary Cilia Immune Receptor Proteins for the Treatment of Polycystic Kidney Disease Mechanisms
… project from the cell surface of mammalian cell and play important roles in vertebrate development, organogenesis, health, and others genetic diseases. Primary cilium functions as a mechano-sensor and chemo-sensor. Defect in primary cilia causes the progression of polycystic kidney disease (PKD) …
-
The Structural Characterization and Bioactivity Assessment of Nonspecific Lipid Transfer Protein 1 (nsLTP1) from Caraway (Carum Carvi) Seeds
… been used in many cultures as a cooking spice and part of the traditional medicine. Previous reports primarily focus on the medicinal properties of caraway seed essential oil and the whole seeds extract. However, no effort has been made to study caraway proteins and their potential …
-
Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
<p>Here, we synthesized a novel group of linear and cyclic amphiphilic peptides containing different sequences of arginine (R) and tryptophan (W) residues. The peptides included a class of cyclic peptides, [R3W3]2, [R3WRW]2, [RWW]4, [WRR]4, [RWRW3]2, and the corresponding linear peptides, (R3WRW)2, …
-
Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes
… known as KSHV or HHV-8, is an emerging pathogen and the causative agent of multiple cancers in immunocompromised patients. KSHV is known to cause four types of malignancies: endothelial-based Kaposi Sarcoma (KS), two rare B cell- based lymphomas; Primary effusion lymphoma, Multicentric …
-
The Influence of Age, Gender, and Thiol Repletion in an In Vivo Model of Lewy Body Disorders
… disorders associated with olfactory, motor, and cognitive deficits and are collectively defined as α-synucleinopathies, as they are characterized by hallmark “Lewy bodies” composed of aggregated, fibrillar α-synuclein. It is not certain but often posited that fibrillar α-synuclein seeds the …
Page 1 of 4