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Showing 1 to 20 of 28 for “"Other Microbiology"”.
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Detection of Bacterial Retroelements Using Genomics
… and are from very different bacterial hosts. The other 2 RT proteins did not show any evidence that they produce msDNA.</p>
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Multiple Posttranscriptional Regulatory Features Control Expression of Ethanolamine Utilization Genes In Enterococcus Faecalis
<p> <p><em>Enterococcus faecalis</em> is a Gram-positive bacterium that lives as a commensal organism in the mammalian gastrointestinal tract, but can behave as an opportunistic pathogen. Our lab discovered that mutation of the <em>eutK</em> gene attenuates virulence of <em>E. faecalis</em> in the …
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Structure and Function Studies on tRNA Splicing Endonuclease
<p>A subset of eukaryotic pre-tRNAs have introns that must be spliced out to become mature molecules capable of functioning in translation. This essential processing step is performed by tRNA splicing endonuclease (TSEN), a highly conserved heterotetramer with two catalytic and two structural …
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The Domains of The Catalytic Subunit of The Eukaryotic Rna Degrading Exosome, Rrp44P, Have Distinct Functions
… aberrantly processed forms of these RNAs, and others, including mRNA. The 3’ to 5’ exoribonuclease activity of the exosome is contributed by the RNB domain of the only catalytically active subunit, Rrp44p, a member of the RNase II family of enzymes. In addition to the RNB domain, Rrp44p …
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Stress-Induced Targeting of Molecular Chaperones In The Yeast Saccharomyces Cerevisiae
… and sporulation phenotypes were shared by another previously identified HSP82 mutant allele, further linking localization to Hsp90 functional status. Pharmacological inhibition of Hsp90 with macbecin in sporulating diploid cells also blocked spore formation, underscoring the importance of …
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Differential progression of pancreatic premalignancy in geographically distant murine transgenic cohorts uncovers key role of microbial metabolites
… consist of transplanting fecal bacteria and other microbes from a donor directly into the gastrointestinal tract of the recipient and have been used clinically to treat conditions as recurrent <em>Clostridioides difficile</em> infections and inflammatory bowel disease. We assessed the ability …
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Functions of The Trna Splicing Endonuclease and Other Adventures In Rna Processing
… in tRNA splicing. However, this enzyme has other functions that are just beginning to be characterized. Mutations in TSEN cause the neuronal disease pontocerebellar hypoplasia (PCH) that is characterized by atrophy of the cerebellum and pons, overall developmental failure, and usually …
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Comparative Analysis of Rhizosphere and Endosphere Microbiome of Different Blueberry Species (Vaccinium sp.)
<p>Blueberries are an important agricultural commodity in all over the United States. Due to its health benefits, there is a huge demand globally, thus expanding the industry. Breeding programs are essential to maintain such industries. Challenges that play a role in contemporary breeding programs …
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Functional Consequences of Rna Exosome Complex Alteration By Conformational Changes and Cofactor Binding
… adaptor protein that bridges the RNA exosome to other cofactors such as an RNA helicase, Mtr4. In this study, I found that Rrp6 and Mtr4 function beyond known biochemical and structural interactions. Mtr4 seems to interact with the RNA exosome independent of the Rrp6 N- terminus. In addition, the …
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Mechanism of Incorporation and Repair of Uracil At Highly Transcribed Genes In Saccharomyces Cerevisiae
<p>Recombination and mutagenesis are elevated by high levels of transcription. The correlation between transcription and genome instability is largely explained by the topological and structural changes in DNA and the associated physical obstacles generated by the transcription machinery. However, …
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Quantitative Analysis and Imaging-Based Insights Into The Characteristics and Mechanisms of Yeast Pattern Formation
<p>Biofilm formation is a common lifestyle adapted by bacteria and fungi in response to various environmental stresses. Bacterial and fungal biofilms adhering to medical devices convey resistance to antibiotics or biocides, causing high rates of clinical infections. Microorganisms are protected …
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The Elasmobranch-Microbe Relationship: Trimethylamine n-oxide Synthesis, Urea Hydrolysis, and Microbe-Osmolyte Interactions in the Atlantic Stingray, <i>Dasyatis sabina</i>
<p>The elasmobranch osmoregulatory strategy is predicated on the accumulation of nitrogenous compounds, primarily urea and trimethylamine n¬-oxide (TMAO). Despite the abundance of these plasma osmolytes, it is notable that elasmobranchs appear to lack urease and TMA oxidase (Tmase), enzymes that …
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Fecal Bacterial Communities as an Indicator of Trophic Interactions Among Anuran Larvae
<p>Anurans are mass spawners, often with multiple females spawning together, resulting in thousands of tadpoles sharing a habitat. Such large numbers of tadpoles with limited dispersal can lead to intense competition for resources. Inter and intra-specific competition for food could have negative …
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Effects of 5��-Dihydrotestosterone (DHT) on Mouse Gut Microbiome– A Study of Sex Differences and Hormonal Effects on Gut Microbiome Composition
<p>Type 1 Diabetes (T1D) is a polygenic and multifactorial disease, traditionally attributed to genetic susceptibility and diet. Over the past decade, novel studies have placed a higher significance on the role of gut microbiome in T1D pathogenesis. Furthermore, diabetic mouse models have shown …
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Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae
… expression of molecular chaperones and other protective targets. Dynamic regulation of HSF1 involves the major heat shock proteins Hsp70 and Hsp90. Recent advances in the understanding of this regulatory circuit in <em>Saccharomyces cerevisiae</em> have shown that the Hsp70 Ssa1 acts as …
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The Gut Microbiome: Is Fecal Matter Microbial Composition a Proxy for Intestinal Microbial Composition in Studies of the Microbiome
… Issues such as allergies, cancer, obesity, and other health complications have been shown to be influenced by the microbiome. Most of gut microbiome research is done by collecting and sequencing the DNA of the microbiome of the fecal matter from model organisms or human subjects. Studies that …
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Efficacy of Ultraviolet Radiation to Control Lactic Acid Bacteria in Wine Must
The use of shortwave ultraviolet (UV<sub>c</sub>) radiation to control lactic acid bacteria (LAB) in wine production was studied. A simulated wine sterilizer was built using a commercially sourced ultraviolet (UV) sterilizer commonly used in aquariums and ponds. After growing cultures in test …
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Development of A Molecular Gram-Stain Assay For The Diagnosis of Blood Stream Infections Associated With Sepsis
… from the Memorial Hermann Hospital Clinical Microbiology Laboratory’s blood culture and Gram- strain analysis. There was 100% agreement between the two positive blood cultures. There was 37% agreement between the 16 culture-negative samples and the MGS assay results. There was 62% …
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