Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Other Genetics and Genomics"”.
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The developmental function of Pax7 : chromatin-immunoprecipitation discovery of Pax7 target genes
… development of brain, spinal cord, neural crest and skeletal muscle. As a sequence-specific DNA-binding transcription factor, the direct functional role played by Pax7 during development is the selection of target genes. To date, an accurate description of the function of this transcription …
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Analysis of the population genetics of the Han and Hui of Liaoning province, Peoples Republic of China
… fluctuated significantly in population numbers and in their political and commercial influence. However, at all times they were considered as important contributors to the nation. Many of these peoples had moved from their homelands, settled in China and had intermarried with Han Chinese. Over …
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Analyzing Extracellular Vesicles for Disease Monitoring in Metastatic Colorectal Cancer Patients
… are the main cause of cancer-related death, and the most frequent metastatic sites in patients with CRCs are liver and lung. To confirm the diagnosis of metastatic CRC (mCRCs) and to classify mCRCs, tumor biopsy of a suspected metastasis is often required. The consensus molecular subtype …
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Helitrons are enriched in lichenized fungi with long generation length and small distribution sizes
… drive genome evolution by introducing mutations and causing structural instability and chromosomal rearrangements, particularly under conditions like environmental or genetic stress. In this study, we generated 18 new long-read reference genomes for lichenized fungi, which form obligate …
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Improving the Phylogenetic Understanding of the Genus Juniperus
<em>Juniperus</em> is a species-rich and geographically widespread genus of coniferous trees and shrubs. The genus is relatively recently diverged, and has experienced periods of rapid diversification. Recent phylogenetic investigations by others have compared DNA from selected regions of the …
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Characterizing A Novel Genetic Locus Associated With Familial Co-Occurrence of Thoracic Aortic Aneurysms and Intracranial Aneurysms
… form of Thoracic Aortic Aneurysms (TAA), and many causal mutations have been identified for this disease. Intracranial Aneurysms (ICA) also show linkage heterogeneity, but no mutations have been identified causing familial ICA alone. Here, we characterized a large family (TAA288) with an …
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Transgenerational epigenetic inheritance via environmental stress in Caenorhabditis elegans
<p>No abstract available</p>
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Exploring the role of the arginine-methylation writer-reader pair PRMT5/SND1 in JAK2-mutant myeloproliferative neoplasms
… in constitutive activation of the JAK2 protein and the JAK-STAT signaling pathway. A role for the methyltransferase activity of Protein Arginine Methyltransferase 5 (PRMT5) has been proposed in JAK2-mutant MPN, highlighting both a mechanism through which this mutation can drive disease …
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Hypoglycemia In Mitochondrial Disorders
… conditions affecting the heart, muscles, and especially brain. The endocrine system is commonly affected in MTDs, and diabetes and hyperglycemia are established secondary diagnoses. Rates of non-iatrogenic hypoglycemia have not been studied in individuals with MTDs. This study aims to …
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Environmental DNA is an Effective Method to Monitor Species in Various Freshwater Habitats
… (eDNA) to monitor three amphibian species and two trout species associated with habitat intersected by Interstate-90 in Snoqualmie Pass, Washington. This included a large catchment area within creeks and nearby wetlands historically affected by I-90, including sites where significant …
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Effects of m6A DNA methylation by bacterial methyltransferase in colorectal cancer
… in colorectal cancer Fabian Alejandro Mendoza Galvan Advisory Professor: Angela H. Ting, Ph.D. Fusobacterium nucleatum animalis (Fna) is found in the human oral cavity and gut. A distinct clade of Fna is primarily enriched in the tumor microenvironment (TME) and within colorectal …
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Vascular Injury In Col3A1+/- Mice Model of Vascular Ehler-Danlos Syndrome
… bruised skin, indicating aberrant wound healing and injury repair ability. Over 70% of the patients carry a glycine mutation located in their <em>COL3A1 </em>gene, which encodes the propeptide of type III collagen. Mutations in glycine residues lead to a disruption in the assembly and maturation …
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Floral trait architecture in crop sunflower (<i>Helianthus annuus</i>) under drought conditions
<p>Longer and more intense droughts are predicted to become more common in the coming century due to anthropogenic climate change. Drought can reduce crop yield and decrease food security. In order to mitigate the negative effects of drought on crop production, it is important to elucidate the …
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Patient Preferences for Ultrasound Soft Sign Disclosure with Prior Negative cfDNA Screening
… screening, which exhibits superior sensitivity and specificity for aneuploidy compared to what can be provided by soft sign risk adjustment, the utility of these soft signs is arguably waning. Thus, this study aimed to establish patient preferences for whether and how soft signs are disclosed in …
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Trim24 As An Oncogene In The Mammary Gland
… the many advances made in breast cancer research and treatments, breast cancer remains one of the deadliest diseases plaguing women worldwide. While many findings on genetic mutations and their role in predisposing people to breast cancer have been uncovered, we are just beginning to understand …
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THE STATUS OF INVASIVE DUSKY SLUG (ARION) SPECIES IN THE UPPER GREAT LAKES: A MOLECULAR APPROACH
… two cryptic slug species, <em>Arion fuscus </em>and <em>Arion subfuscus</em>,<em> </em>in the Upper Great Lakes of the United States using molecular identification methods. <em>Arion fuscus </em>has not previously been reported in the literature in this region, and <em>Arion subfuscus </em>has …
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Invisible Disabilities, Academic Capital and Competitiveness of Genetic Counseling Applicants
… concerns about cost, familial expectations, and navigation of systems. Genetic counseling applicants for the 2021 and 2022 admissions match cycles were recruited via a multipronged, snowball method and surveyed via Qualtrics (IRB# HSC-MS-21-0477). Responses were analyzed using IBM SPSS …
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Npsd4: A New Player In Sumo-Dependent Dna Repair
… is under constant threat from sources of damage and stress. Improper resolution of DNA damage lesions can lead to mutations, oncogene activation, and genomic instability. Difficult-to-replicate-loci present barriers to DNA replication that, when not properly resolved, lead to replication fork …
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Identifying Functional Enhancers For Fibrotic Gene Regulation In Liver Fibrosis
… by progressive activation of proliferating and migrating myofibroblasts that lead to accumulation of extracellular matrix (ECM). These myofibroblasts most arise from activated liver-resident hepatic stellate cells (HSCs). There is an increasing number of patients suffering from liver …
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Genetic Testing Practices of Genetic Counselors, Geneticists, and Pediatric Neurologists With Regard to Childhood-Onset Neurogenetic Conditions
… disorder (ASD), intellectual disability, and epilepsy, is critical to providing proper medical management for these patients and their families. However, many patients with these conditions are not tested appropriately or receive no genetic testing at all. The current study was designed to …
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