Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Other Clinical Medicine"”.
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Hormonal factors in rheumatoid arthritis – Their impact on disease risk and severity
… in Malmö between 1974 and 1992 (Malmö preventive medicine programme, (MPMP)) and 1991-1996 (Malmö diet and cancer study (MDCS), respectively). Participants answered a questionnaire and blood samples were collected. We identified incident cases of RA by linking the cohorts to four different RA …
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Autonomic dysfunction in primary Sjögren's syndrome
… Sjögren’s syndrome (pSS) and to evaluate its clinical associations. In study I, 46 pSS patients and 56/80/238 autonomic nervous function test (ANT) controls participated. Objective signs of AD were evaluated using three different cardiovascular ANTs and exocrine function in pSS patients by the …
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Death, survival, and morphological development of hippocampal granule cells born in an inflammatory environment
The brain continues to form new neurons throughout life. This process of adult neurogenesis has been thoroughly documented in several species including birds, rodents and humans. Adult neurogenesis is not a global process, but is confined to two subcompartments of the brain; the subventricular zone …
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Natriuretic Peptides and the Microcirkulation in Heart Failure Patients
The increased prevalence of chronic congestive heart failure (HF) is a tremendous challenge for society. In spite of effective medical treatment for acute HF, better pharmacological treatment for specific neurohormonal intervention and better diagnostic tools, e.g. biomarkers of natriuretic …
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Clinical and epidemiologic aspects of Rheumatoid Arthritis. Special emphasis on cardiovascular outcome and risk factors
… we used two large surveys, the Malmö Preventive Medicine Program and the Malmö Diet Cancer Study. Cardiovascular morbidity and mortality in the two community based RA cohorts was increased compared to the background population. Treatment with adalimumab was associated with decreased expression of …
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Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
Bacterial infections and sepsis are amongst the leading causes of death worldwide. Sepsis is caused by an uncontrolled systemic host response towards an invading pathogen. Due to the engagement of various systems including cellmediated responses, the coagulation and complement cascades, treatment …
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Studies on cellular changes and amnesia in a rat model of electroconvulsive therapy
… for severe depressive disorder, but its clinical use has been limited by concerns about side effects such as memory disturbances. Despite over 70 years in clinical use, the exact mechanisms of action behind the therapeutic or adverse effects are not fully understood. Enhanced brain …
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Circulating proteoglycans and glycosaminoglycans during critical illness
… that probably has limited value as a marker in clinical practice.
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Treatment and outcome of anterior cruciate ligament injury: Truth or Consequences
… knee. The KANON-study, a randomized controlled clinical trial comparing surgical and non-surgical treatment after acute ACL injury, was initiated and some results are included in this thesis. 642 subjects with acute knee injury were assessed in order to include 121 subjects in this RCT. …
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Gestational Diabetes Mellitus- Future risk for mother and child
… and eventual future risks for children born to mothers with a previous GDM are less well studied. In this thesis women who had GDM during 1995-2010 and their children were investigated. Aims Paper I-III: Determine how many women with GDM that have beta-cell specific autoantibodies such as …
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In-hospital bed occupancy and the emergency department - effects on decisions about the level of care
… to a hospital bed at times of access block than otherwise. Part V addressed whether more patients were triaged out of the ED at times of access block. Methods: In Part I, the proportion of hospital admissions among 118,668 visits to the ED, at a 420-bed emergency hospital in Region Skåne, Sweden, …
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
Human autoimmune diseases such as reumatoid arthritis (RA) and multiple sclerosis (MS) are believed to develop when self-tolerance mechanisms are failing, with a chronic destructive inflammation as result. To experimentally study autoimmunity, we have used murine models that mimic their human …
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Knee function, movement pattern and knee osteoarthritis in males 14-16 years after an anterior cruciate ligament injury
… cross-over hop and one-leg hop. Four physiotherapists were used as observers. The physiotherapists assessed the knee function of the subjects with an ACL injury before and after the training period using video sequences. The reliability between the physiotherapists was relatively good and …
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Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)
This thesis explores the relation between gonadotropin-releasing hormone (GnRH) and gastrointestinal symptoms and dysmotility. In primary Sjögren’s syndrome (pSS), a patient group with high levels of GnRH antibodies, associations between objective signs and symptoms of autonomic dysfunction (AD), …
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The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion
Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose …
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Propionibacterium acnes and its phages
Microorganisms are everywhere! They can tolerate many diverse extreme environments, such as the human body. Even though many of us might associate the word microorganism with infections and disease, most are actually either harmless or even beneficial for us. Those commensals often fight off more …
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Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease
The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems …
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Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)
… and a slower progression to beta cell failure at clinical onset compared to subjects with type 1 diabetes. Furthermore, there are adult onset type 1 diabetic patients that share the rapid progression to beta cell failure with juvenile onset diabetes. The hypothesis was therefore that type 1 …
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Rhinomanometry in clinical use. A tool in the septoplasty decision making process.
… aim of this thesis was to investigate the clinical use of rhinomanometry in the septoplasty decision making process. This resulted in a checklist to increase the patients’ satisfaction with the operation. We found that higher age and allergic rhinitis were factors giving significant odds …
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MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
… results are more modest than predicted from pre-clinical studies, reflecting the complexity of tumor angiogenesis, and underlining the requirement of further studies aiming at the identification of the inherent limitations of this treatment as well as new targets of anti-angiogenic therapy. This …
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