Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Other Biomedical Engineering and Bioengineering"”.
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Assessment of Morphology and Hemodynamics in Normal and Remodeled Microvasculature with Parameter Sensitivity Analysis
… of this study was to compare the morphological and hemodynamic characteristics of normal and remodeled vascular networks in the mouse gracilis muscle. To this end, previously developed models to assess flows and vascular branching were used to assess the normal and remodeled microcirculatory …
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Analysis of Eye Movements to Cartoon Faces in Videos
… are indicative of how we direct our attention and therefore play a role in memory and cognition. For static images, it is established that saccades move faster to faces compared to other objects. We hypothesize that the same is true for videos. To test this hypothesis, saccades to faces in …
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The Characterization of Biofilm Attachment to Metal Interfaces: Effects of Substratum Properties
… among the most abundant microorganisms on earth, and can be found in essentially every environment. When a clean surface is exposed to media containing planktonic bacteria, the bacterial cells will attach to the surface and aggregate to form what is known as a biofilm. Biofilms have been shown to …
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Application of Argon Plasma Technology to Hydrophobic and Hydrophilic Microdroplet Generation in PDMS Microfluidic Devices
… of Argon Plasma Technology to Hydrophobic and Hydrophilic Microdroplet Generation in PDMS Microfluidic Devices Brennan Graham Microfluidics has gained popularity over the last decade due to the ability to replace many large, expensive laboratory processes with small handheld chips with a …
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Biofidelic Piezoresistive Sandwich Composites
… biofidelic surrogates are being used in many biomedical applications; e.g. to understand the body injury mechanisms, evaluate protective equipment like helmets and armors. Apart from matching the mechanical behavior of bodily tissues, there is an increasing requirement for these materials to …
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A New Computational Model to Augment the Design of Microfluidic Separations: Electric Field Assisted, Hydrodynamic Chromatography
… in separations to assist with the optimization and design of microfluidic systems.</p> <p>This project differs from other computational models in that it utilizes a personal computer to run the simulation in an optimized format rather than utilizing a highly parallelized system for the …
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An Investigative Study Into the Relationship of Bone Morphogenetic Protein Antagonist Expression and Osteocyte Density by Region and Quadrant
The role of cytokines and cell behavior and viability with respect to bone remodeling and bone behavior is an exciting area of orthopedic research. The purpose of this study was to investigate the relationships between BMP antagonist expression and osteocyte density, lacunar densities and osteocyte …
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Sex Differences in Collateral Remodeling Following Hindlimb Arterial Occlusion
… of peripheral arterial occlusive disease and associated likelihood of critical limb ischemia in women, as well as worse prognosis and decreased survival post myocardial infarction. Therefore, understanding the possible differences in underlying vascular compensation mechanisms is crucial. …
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Knockdown of Heparan Sulfate Via NDST1 knockout Does Not Inhibit Mouse Aortic Endothelial Cell Alignment In-Vivo
… localizes in predictable areas such as arches and bifurcations which are characterized by disturbed flow patterns and the resulting damage and dysfunction to the endothelium. Endothelial cells (ECs) under sustained laminar flow align in the direction of flow; however, under disturbed flow …
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Mechanical Simulation of Articular Cartilage Based on Experimental Results
… cartilage (AC) biomechanical properties before and after growth. Previous research has noted limitations in the CGFEM such as model convergence with growth periods greater than 12 days. The main aims of this work were to address these limitations through (1) implementation of an exact material …
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Comparing Anti-VEGF Antibodies and Aptamers on Paper Microfluidic-Based Platforms
<p>The field of microfluidics is expanding into what is known as paper microfluidics. This uses a paper platform rather than materials (i.e. PDMS, PMMA) that are commonly used in microfluidics research. Current devices require an expensive manufacturing process and external sources to power the …
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Modeling of NK Cells in Pediatric Patients With Unusually Severe or Recurrent HSV Using High-Dimensional Flow Cytometry
… over the world with some patients having severe and/or recurrent HSV infections. Our lab studies human Natural Killer (NK) cells, which are important in innate immune responses to viral infections and tumors. A publication in 2013 by Ornstein et al from our lab studied HSV+ pediatric patients and …
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The Impacts of Arterial Occlusion, Sex, and Exercise on Arteriogenesis and Functional Vasodilation
… vasodilation. Patients demonstrate both local and systemic impairments in vasodilation, but as the collateral circulation is the primary site of resistance to the ischemic zone, impaired collateral vasodilation would have the greatest potential to induce claudication. Collateral function …
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Do Canines Experience the Effects of Heart Rate Turbulence?
… study whether HRT is present following a PVC in otherwise healthy canines.</p> <p><b>Methods</p></b> <p>For multiple months, five non-medicated, healthy canines were chronically monitored from between 1 and 8 sessions each. At each session, the canines were ventricularly paced to induce PVCs. …
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Neural processing of semantic content in movies
… such as movies, contain interacting, multimodal and semantic features and allow for free exploration through eye movements. The full extent of neural responses to features such as motion, film cuts and eye movement behavior has not been established. The main hypothesis of this thesis is that …
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Mechanisms for regenerative intervertebral disc healing during early growth in mice
… adjacent nerves. Discectomy, the current standard of treatment to address herniation, does not repair AF defects and can result in re-herniation and recurrent pain. As such there is a need for improved AF repair strategies. It has previously been established that neonatal mice functionally …
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Modeling Action Potential Propagation During Hypertrophic Cardiomyopathy Through a Three-Dimensional Computational Model
… (HCM) is the most common monogenic disorder and the leading cause of sudden arrhythmic death in children and young adults. It is typically asymptomatic and first manifests itself during cardiac arrest, making it a challenge to diagnose in advance. Computational models can explore and reveal …
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A 3-Dimensional In Silico Test Bed for Radiofrequency Ablation Catheter Design Evaluation and Optimization
… areas from the rest of the atrium. The standard <em>in vitro</em> evaluation of ablation catheters through lesion studies is a resource intensive effort due to tissue variability and visual measurement methods, necessitating large sample sizes and multiple prototype builds. A computational …
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Ultra-high Field MRI Methods for Precise Anatomical and Spectroscopic Measurements in the Brain and Application to Neurological and Neuropsychiatric Diseases
<p>Neurological and neuropsychiatric diseases and disorders are a major burden on society, impairing the health and functioning of millions of people every year. There is a need to define the biological bases of these diseases and identify potential biomarkers to improve diagnosis, monitoring, and …
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Improvement of Statistical Process Control at St. Jude Medical's Cardiac Manufacturing Facility
… users to identify special causes, or shifts, and can therefore change the process to keep producing good products, free of defects. </p> <p> There are many factories and manufacturing facilities having implemented some sort of statistical process control. St. Jude Medical implemented control …
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