Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Other Biochemistry, Biophysics, and Structural Biology"”.
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Conformation of the U12-U6atac snRNA Complex of the Minor Spliceosome and Binding by NTC-related Protein RBM22
… non-coding regions, called introns, are removed and coding regions, or exons, are ligated to form a mature mRNA. This process is catalyzed by the spliceosome, a multi-mega Dalton ribonucleoprotein complex assembled from five small nuclear ribonucleoproteins (snRNP) in the form of small nuclear …
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Confirmation of Emx2 Protein Binding Partners
… that processes sensory input from eyes, ears, and touch receptors and mediates the conscious use of skeletal muscles. The processing of information related to each of these types of functions is localized within discrete areas of the neocortex, which are separated by sharp borders. Proper …
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Regulation of Actin Dynamics During Drosophila Germband Extension
… body plan. In fly embryos, this is known as germband extension and is mainly driven by cell intercalation or neighbor exchange by planar polarized cell-cell interface contraction to shorten the tissue along the dorsal-ventral axis. In this thesis, I show that interface contraction consists of …
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Molecular Dynamics Simulations Provide Insight into Stability of Hyperthermophilic Endoglucanases
… requires the utilization of high temperatures and is currently limited by the thermostability of endoglucanases. For this reason, it would be beneficial to discover more high-efficiency, thermostable enzymes to utilize in the hydrolytic process. In this study molecular dynamics simulations were …
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Synthesis, Kinetic and Photocatalytic Studies of Porphyrin-Ruthenium-Oxo Complexes
Macrocyclic ligand-complexed transition metal-oxo intermediates are the active oxidizing species in a variety of important biological and catalytic oxidation reactions. Many transition metal catalysts have been designed to mimic the predominant oxidation catalysts in Nature, namely the cytochrome …
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Lipid Composition and Configuration Drive Biophysical Properties of The Mammalian Plasma Membrane
… lipidomics, our lab confirmed PL class asymmetry and surprisingly measured the endoplasmic leaflet to contain double the number of PLs vs. the exoplasmic leaflet. My re-analysis of classical studies show that PM PL abundance imbalance has been a consistent finding across decades of literature. …
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Design and Characterization of Chimeric Probes Specific to K48-K63-linked Heterotypic Ubiquitin Chains
… central role in orchestrating cellular processes and regulating dynamic molecular interactions. Consequently, dissecting the mechanisms that govern diverse biological pathways relies heavily on our ability to interpret the complexity of ubiquitin modifications. A persistent challenge in the field …
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A Hydrodynamic Method for Measuring Aqueous Nanoparticle Surface Interactions
… of this research dissertation were to develop and present novel analytical methods for the quantification of surface binding interactions between aqueous nanoparticles and water-soluble organic solutes. Quantification of nanoparticle surface interactions are presented in this work as …
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Modulation of Kras Structure and Dynamics By Kras Ubiquitination and Membrane Depolarization
… of KRAS with its regulators, effectors, and the membrane present one such avenue. In this study, we investigated how post-translational covalent and environmental modifications could modulate these interactions of KRAS. Using computational molecular dynamics simulations, nuclear magnetic …
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Dissecting The Interaction Between P53 and Trim24
<p>Dissecting the Interaction of p53 and TRIM24</p> <p>Aundrietta DeVan Duncan</p> <p>Supervisory Professor, Michelle Barton, Ph.D.</p> <p>p53, the “guardian of the genome”, plays an important role in multiple biological processes including cell cycle, angiogenesis, DNA repair and apoptosis. …
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SOLVING THE CABLE EQUATION, A SECOND-ORDER TIME DEPENDENT PDE FOR NON-IDEAL CABLES WITH ACTION POTENTIALS IN THE MAMMALIAN BRAIN USING KSS METHODS
… method with Forward Euler, Backward Euler and Crank-Nicolson to solve the Cable Equation. The Cable Equation measures action potentials in axons in a mammalian brain treated as an ideal cable in the first part of the study. We shall subject this problem to the further assumption of a …
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An Assessment of Potential False Positive E.coli Pyroprints in the CPLOP Database
… found in each species of organism is unique, and can be used as a tool to differentiate at the molecular level. This has caused rapid genotyping methods to become the cornerstone of a new area of research dependent on reading the genome as a form of identification. One of these specific …
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… (PDAC) is challenging due to asymptomatic nature and deep location of the malignancy within the abdomen. The development of PDAC consists of three different pathways but two arise from the duct, Pancreatic Intraepithelial Neoplasia (PanIN) and Intraductal Papillary Mucinous Neoplasm (IPMN). During …
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Analyzing Functional Interactions of Designed Peptides by NMR Spectroscopy
… of relationships between the peptide structure and its functional interactions. Here, we report the analysis of two groups of synthetic peptides designed for two applications – broad bactericidal action and inhibition of protein-protein interactions in human cells. Novel amphiphilic peptides …
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Biochemical Assay Optimization and Computational Screening Efforts to Identify Potential LuxS Inhibitors
… small signaling molecule autoinducer-2 (AI-2) and is implicated in the infectious behaviors of various bacterial species. AI-2 is biosynthesized from <em>S-</em>ribosylhomocysteine (SRH) by the enzyme LuxS and induces interspecies cell-to-cell communication. Inhibition of LuxS would therefore …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
… prevalence, there is currently no cure for IPF, and the cause of this disease is still unclear. Our laboratory and collaborators have shown that nudix hydrolase 21 (NUDT21, which is also known as cleavage factor 25, CFIm25) is a key regulator of alternative polyadenylation (APA). NUDT21 depletion …