Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Osteosarcoma Metastasis"”.
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Investigating the role of zoledronate for inhibition of osteosarcoma metastasis
Osteosarcoma (OS) is the most common primary bone tumor in dogs and it accounts for nearly 10% of all diagnosed canine cancers. Despite aggressive multimodality therapy, the mortality rate for canine OS exceeds 90% from the development of distant metastases to lungs and other visceral organs. Given …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… clinical progression seen in most patients with osteosarcoma, where metastasis to the lung is the most common cause of death. The primary research need in the field is to understand the biology of metastasis in osteosarcoma so as to improve outcomes for future patients. Unraveling the complexity …
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Understanding the role of interleukin-8 (IL-8) in canine osteosarcoma metastasis
The student, Matthew Dowling, accepted the attached license on 2018-06-20 at 22:06.
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
Osteosarcoma (OS) is the most common primary malignant bone cancer in children. Despite the improvement in multiagent chemotherapy, 5-year survival rate for metastatic OS is only 20% to 30%. One of the main reasons for failure in therapy is due to the activation of autophagy in metastasis and …
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Metadherin Functions As A Laminin Receptor That Is Essential For Metastasis and Is Associated With Poor Survival In Osteosarcoma
<p>Osteosarcoma is a highly invasive bone malignancy in which metastasis accounts for the vast majority of death and morbidity in patients. Understanding the mechanisms controlling metastasis is essential for improving patient survival in this disease. In order to improve the clinical outcomes for …
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Exosomal Communication By Metastatic Osteosarcoma Cells Modulates Alveolar Macrophages to An M2 Tumor-Promoting Phenotype and Inhibits Tumoricidal Functions
<p>Osteosarcoma metastasizes to the lung, and there is a link between the predominance of tumor promoting immunosuppressive M2<em> </em>macrophages in the metastases and poor patient survival. By contrast, M1<em></em>macrophage predominance correlates with longer survival. M2 macrophages can be …