Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 139 for “"Osteosarcoma"”.
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Tratamiento actual del osteosarcoma
… aplicados a los enfermos afectos de osteosarcoma. Planteamiento del problema se realizo un estudio general sobre el osteosarcoma con una revisión bibliográfica de todos los aspectos clínico-patológicos, así como de los diversos tratamientos de quimioterapia y cirugía, desde las …
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Characterization of Erbb4 Expression In Osteosarcoma
… in studies characterizing ERBB4 expression in osteosarcoma, indicating that ERBB4 may be cleaved to enhance malignant behavior in osteosarcoma. ERBB4 protein was significantly up-regulated from monolayer to sphere cultures in osteosarcoma, leading to the hypothesis that there would be an …
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Improving Nk Cell Therapy For Osteosarcoma
<p>Osteosarcoma (OS) is the most common primary bone tumor. Despite new treatment options, 5-year survival for metastatic OS has remained at only 30% for the last 30 years. Adoptive transfer of Natural Killer (NK) cells holds promise for a new, non-toxic therapy for OS. NK cells are part of the …
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The role of autophagy in canine osteosarcoma
Canine osteosarcoma (OS) is a primary tumour in the bone and is mesenchymal in origin. The common sites affected are the metaphyseal regions of long bones, particularly the front limbs of dogs. Osteosarcoma in dogs shares many biological and clinical resemblances in humans with molecular and …
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The role of cancer stem cells in osteosarcoma
Osteosarcoma (OS) is the most common bone malignancy often producing aggressive tumours in adolescents. OS aetiology is poorly understood, however, recent studies suggest OS cancers contain a small population of cancer stem cells (CSC) which initiate tumour growth. The cancer stem cell hypothesis …
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… cause of death for patients with pediatric osteosarcoma (OS). OS has a high degree of heterogeneity and genomic instability, making understanding the pathogenesis and drivers of metastasis of this disease challenging. In an effort to explain tumoral heterogeneity, the tumor initiating cell …
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Inhibition of the autophagy pathway modulates osteosarcoma chemoresistance
Osteosarcoma is the most common primary malignant bone tumour. Although the introduction of chemotherapy has improved the survival rate of osteosarcoma patients, chemoresistance remains a major clinical problem underlying poor survival outcome. Previous studies have shown that deregulation of a …
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Targeted gene therapy for canine osteosarcoma: preliminary investigations
Osteosarcoma (OS) is the most common bone cancer in dogs. It is biologically aggressive and <20% survive >2 years with standard therapy. Hence, new approaches must be considered. TP53 is altered in ~50% of human and canine cancers, including OS, making it a candidate for targeted suicide gene …
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Hsp27 and Chemotherapy-Induced Autophagy As Biomarkers In Osteosarcoma
<p>Survival for patients with osteosarcoma has not improved for > 30 years. Despite aggressive multi-agent chemotherapy combined with surgical resection, a significant fraction of patients with localized disease relapse after optimal treatment. We evaluated the occurrence of cytoplasmic LC3B (light …
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Bi-functional scaffold for bone regeneration after osteosarcoma resection
L'abstract è presente nell'allegato / the abstract is in the attachment
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
Osteosarcoma is the most common primary malignant bone tumor in children, adolescents, and dogs. Lethality is due to lung metastases. Despite standard of care, patients with lung metastases have a survival rate of only 25%. Therefore, our lab studied potential therapeutics to target lung …
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Role of biomechanics and tumor microenvironment in osteosarcoma progression
… physical and biochemical, present in the osteosarcoma tissue microenvironment and connect them to give a broader understanding of the tumor microenvironment and the interactions between cellular neighborhoods. Chapter 1 is an introduction and a detailed review of existing literature on the …
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Role of Amplification of Chromosome 6P12-P21 in Human Osteosarcoma
Osteosarcoma is an aggressive bone malignancy with neither reliable prognostic or predictive biomarkers nor drugs for targeted therapy. It is the most common malignant tumour of bone, predominantly occurring in adolescents. Currently, the mainstay of treatment is surgical resection in combination …
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CRISPR/Cas9-mediated ATG7 knockout results in enhanced osteosarcoma chemosensitivity
… of chemotherapy, the survival rates in Osteosarcoma (OS) have improved immensely in patients with the localised disease. Despite this, long-term survival rates for OS patients facing metastatic or recurrent disease remains unchanged. One of the main reasons for this is resistance to …
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Investigating the role of zoledronate for inhibition of osteosarcoma metastasis
Osteosarcoma (OS) is the most common primary bone tumor in dogs and it accounts for nearly 10% of all diagnosed canine cancers. Despite aggressive multimodality therapy, the mortality rate for canine OS exceeds 90% from the development of distant metastases to lungs and other visceral organs. Given …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
Canine osteosarcoma (OS) is a malignant neoplasia of the osteoblast, most often identified in the appendicular skeleton, which is both locally aggressive and highly metastatic. The standard of care treatment of amputation and adjuvant chemotherapy yields a median survival time of 10-12 months, an …
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Investigating procaspase-3 as a potential therapeutic target in canine osteosarcoma
… activating compound, in the treatment of canine osteosarcoma. Procaspase-3 is expressed in osteosarcoma cells, and furthermore, greater expression is seen in malignant canine osteoblasts than normal osteoblasts. Exposing cells to PAC-1 results in the activation of procaspase-3 to caspase-3, …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… clinical progression seen in most patients with osteosarcoma, where metastasis to the lung is the most common cause of death. The primary research need in the field is to understand the biology of metastasis in osteosarcoma so as to improve outcomes for future patients. Unraveling the complexity …
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