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Showing 1 to 17 of 17 for “"Osteoprotegerin"”.
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RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces
… (RANKL)—is critical for osteoclastogenesis, and osteoprotegerin (OPG) is a decoy ligand that competitively inhibits RANKL. A higher RANKL/OPG ratio is associated with areas of bone resorption, while a lower ratio occurs in areas of bone deposition and homeostasis. There have been almost no …
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Osteoprotegerin: a pathological role in human abdominal aortic aneurysm
… necrosis factor receptor superfamily known as osteoprotegerin (OPG) is constitutively expressed within the human artery wall and, under pathological conditions, is upregulated and associated with vascular disease. Elaboration on the involvement OPG of in AAA will determine its potential as a …
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Modulation of RANKL and Osteoprotegerin in Adolescents Using Orthodontic Forces
… (RANKL)--is critical for osteoclastogenesis, and osteoprotegerin (OPG) is a decoy ligand that competitively inhibits RANKL. A higher RANKL/OPG ratio is associated with areas of bone resorption, while a lower ratio occurs in areas of bone deposition and homeostasis. There has been almost no …
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Serum Osteoprotegerin, a Potential Novel Marker of Systemic Inflammation: The Influence of Obesity, Insulin Sensitivity and Oral Glucose Loading on its Circulating Concentrations
Circulating osteoprotegerin (OPG) promotes bone formation in vivo and correlates with the presence of type 2 diabetes, severity of vascular calcification and coronary artery disease. Obesity is a risk factor for diabetes and cardiovascular disease but little is known about the impact of body weight …
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Serum levels of osteoprotegerin and glucometabolic indices in subjects with newly detected glycemic abnormalities // Серумни нива на остеопротегерин и глюкометаболитни показатели при лица с новооткрити гликемични нарушения
Малко са данните за циркулиращите нива на ОПГ при лица с новооткрит тип 2 диабет (нТ2ЗД), както и асоциирането на ОПГ с различни глюкометаболитни показатели и маркери за ранна съдова увреда. В хода на нашето проучване проведохме две скринингови програми за търсене на гликемични нарушения сред …
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Physical training, inflammation and bone integrity in elite female rowers
… factors that regulate bone (sclerostin (SOST), osteoprotegerin (OPG)), and receptor activator of nuclear factor kappa-B ligand (RANKL)) and energy metabolism (insulin-like growth factor-1 (IGF-1) and leptin), and inflammation (tumor necrosis factor-α (TNF-α)) in elite heavyweight female rowers. …
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Muscular Strength Training Modifies Regulation of Bone Remodeling: Inferences From Serum Biomarkers in Young Women
… for nuclear factor kappa-beta ligand (RANKL), osteoprotegerin (OPG), osteocalcin, and N-telopeptide (NTx) were measured in women aged 20 + 1.5 years (mean + SD) who underwent 32 weeks of unilateral isokinetic concentric or eccentric muscular strength training. Changes in serum biomarkers were …
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In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis
… transforming growth factor beta (TGF-~), and osteoprotegerin (OPG). In addition, Bcell precursors are able to differentiate into osteoclasts in vitro. However, the role of B cells in bone metabolism and osteoporosis is still largely unknown, particularly at the systematic expression level in …
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Osteolyse beim Multiplen Myelom : Untersuchungen am Zellmodell
… ligand (RANKL) and the soluble decoy receptor osteoprotegerin (OPG). Binding of RANKL to RANK leads to osteoclastogenesis and osteolysis whereas binding to OPG inactivates RANKL. Myeloma cells seem to disturb bone marrow microenvironment in a manner tipping the balance towards osteolysis. On …
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Kalirin : novel role in osteocyte function
… in MLO-Y4 cells. Moreover, the mRNA levels of osteoprotegerin (OPG) and SOST, which are important for controlling osteoclast differentiation and Wnt signaling leading to bone formation, respectively, were reduced in Kal-KO osteocytes. Next, the role of Kalirin in osteocyte morphology and …
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The Fruit of Poncirius Trifoliata Promotes Mesenchymal Stem Cell Differentiation into Osteoblasts in Glucocorticoid-induced Osteoporosis Model
… through inhibition of ALP activity, Runx2, OC, osteoprotegerin (OPG) expression and mineral nodule formation. However, poncirin induced mesenchymal stem cell differentiation into osteoblasts in DEX-treated C3H10T1/2 cells. It was tested that whether DEX inhibited Runx2 expression through smurf1 …
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Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering
… induced osteocalcin (OCN), osteopontin (OPN), osteoprotegerin (OPG), vascular endothelial growth factors (VEGF), and cyclooxygenase 2 (COX-2) mRNA at 8 hour post-heating (PH). The addition of GFs with heating induced OPG and VEGF genes more than heating or GF addition alone. OPN, OCN, and OPG …
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Μελέτη της ετερότοπης οστεοποίησης νευρογενούς αιτιολογίας
… – sRANKL εμφανίζει τα εξής χαρακτηριστικά: η osteoprotegerin είναι μετρήσιμη και αυξάνει προς το τέλος των μετρήσεων. Το sRANKL απεναντίας δεν είναι μετρήσιμο σε καμία χρονική στιγμή κατόπιν της ΚΕΚ. Τα παραπάνω συνεπάγονται ότι η ΚΕΚ είναι παράγων επαγωγής οστεοβλαστικής δραστηριότητας όχι …
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Uraemic vascular damage and calcification in children with chronic kidney disease
… circulating calcification inhibitors, fetuin-A, osteoprotegerin and Matrix Gla-protein, may influence an individual patients’ susceptibility to calcify, and but have not been described in children. I found that these levels influenced vascular stiffness and calcification, and that there may be a …
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Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts
… RANKL are blocked by its soluble decoy receptor, osteoprotegerin (OPG), thus inhibiting osteoclast differentiation, activation and survival. RANKL and OPG are produced by many cells in the body including human gingival fibroblasts and PDL cells. At the moment, no data exist comparing the effect of …
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Wirkungsweise von Bisphosphonaten auf die Expression verschiedener Knochenmarker in mesenchymalen Stammzellen der Plazenta
Humane mesenchymale Stammzellen (hMSC) sind u. a. Ausgangspunkt für die Differenzierung zu Osteoblasten. Sie bieten Ansatzpunkte für die Weiterentwicklung von Gewebeersatzverfahren im Rahmen der regenerativen Medizin (Tissue Engineering). Als alternative Ressource zum Knochenmark für die Gewinnung …