Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Osteoprogenitor"”.
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Impact of Hyperglycemia on Rat Cortical Bone Microstructure and Osteoprogenitor Cell Exhaustion
… number due to the excessive proliferation of osteoprogenitors increases osteocyte lacunar density in hyperglycemic bone. To address the hypothesis, changes in bone porosity, due to osteocyte lacunar density and vascular canal volume, in streptozotocin (STZ)-induced hyperglycemic Wistar Albino …
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Cellular Responses to Short-Term Mechanical Loading: Relative Involvement of Osteoblasts, Pre-Osteoblasts, and Osteoprogenitor Cells
Bone is an organ that is highly sensitive to changes in its mechanical loading environment. Although it is known that increased mechanical loading results in new bone formation, the cellular mechanisms underlying this response remain unclear. This investigation applied in vivo and in vitro …
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Engineered [beta]TCP-binding HER-family protein fusions and their use for improving osteoprogenitor- mediated bone regeneration
… and proliferation of the marrow-resident osteoprogenitors (CTPs) can be limited in large defects by the inflammatory microenvironment. Ligands that can improve CTP survival and other relevant upstream processes like colony formation and proliferation should advance bone healing. One such …
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In Vitro Assessment of Bone and Cartilage Stimulating Peptides
… concentrations with respect to their effects on osteoprogenitor proliferation, osteogenic differentiation, cell culture mineralization and cell migration. BCSPs appeared to enhance the bone growth in the previous study using an animal model; however, the cellular and molecular mechanisms of BCSPs …
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Non-invasive shock wave stimulated periosteum for bone tissue engineering
… cambium cells of the periosteum, which are known osteoprogenitor cells, have limited suitability for clinical applications of bone tissue engineering due to their low cell number (2-5 cells thick). Extracorporeal shock waves (ESWs) have been reported to cause thickening of the cambium layer and …
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Application of Fluid Flow for Functional Tissue Engineering of Bone Marrow Stromal Cells
… of a biomaterial scaffold, pharmaceutics, and osteoprogenitor cells. One source of osteoprogenitor cells is bone marrow stroma, which can be obtained from the patient - minimizing the risk of an immune response - directed in vitro to proliferate, and differentiate into a bone-like tissue. To …
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Modulation of Osteoblast Differentiation in Rat Calvarial Cells: Investigations into Effects of Mechanical Load and Interleukin-1β
… if mechanical load induces differentiation of osteoprogenitor cells. This study used an in vitro mechanical loading model of rat calvarial osteoblasts to determine if loading affected differentiation of osteoprogenitor cells. Measurements of prostaglandin and nitric oxide, two possible …
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Bioactive Poly(Lactic-co-Glycolic Acid)-Calcium Phosphate Scaffolds for Bone Tissue Regeneration
… calcium and phosphate ions to differentiating osteoprogenitor cells, thereby stimulating osteogenesis when implanted in vivo. In this research, the effect of zinc on the differentiation of osteoprogenitor cells was investigated. Zinc supplementation of the culture media had no stimulatory …
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Controlled release of gentamicin from polyelectrolyte multilayers to treat implant-related infection
… products were generally nontoxic toward MC3T3-E1 osteoprogenitor cells. A reproducible in vivo rabbit bone infection model was developed to test the PEM coatings against sterile, uncoated placebos; subsequent in vivo experimentation demonstrated the proof-of-principle that an antibiotic-eluting …
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Biodegradable polymer scaffold fabrication and the creation of tissue-engineered bone
… believe this tissue may have a large number of osteoprogenitor cells of periosteal origin and may therefore possess significant osteogenic potential. The methodologies developed and described in this thesis represent powerful regenerative tools which may someday result in the realization of our …
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Comparative in vitro study of the proliferation and growth behavior of human osteoblast-like cells on various 2D-biomaterials
… of human osteoblast-like cells or earlier osteoprogenitor cells into a scaffold followed by the in vitro multiplication and/or differentiation of osteogenic cells before host implantation. The in vitro study of the growth behavior of osteoblasts onto the surface of the biomaterials provided …
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Effects of Mild Heating on the Osteogenic Differentiation of Human Mesenchymal Stem Cells during Inflammation
… to induce proliferation and differentiation of osteoprogenitor cells in vitro. The central hypothesis of our study is that mild heat shock may facilitate the bone and cartilage regeneration from MSCs under inflammatory conditions of osteoarthritis. In this study we focus on the osteocentric …
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Osteoblast Response to Zirconia-Hybridized Pyrophosphate Stabilized Amorphous Calcium Phosphate
… of Zr-ACP, a MC3T3-E1 mouse calvarial-derived osteoprogenitor cell line was used to measure cell response to Zr-ACP. To accomplish this objective, Zr-ACP was added to cell culture at different stages in cell maturation (days 0, 4 and 11). DNA synthesis, alkaline phosphatase (ALP) activity, …
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Electrospun Nanocellulose: A New Biomaterial
… solutions. Porosity and Ca-P crystals enhanced osteoprogenitor cell adhesion on the electrospun cellulose scaffolds. Cationic modification by trimethyl ammonium betahydroxy propyl (THAMP) derivation and adsorption of extracellular matrix proteins on cellulose fibers promoted adhesion and …
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Cell Kinetics of Osteoblast Histogenesis in Evolving Rabbit Secondary Haversian Systems Using a Double Labeling Technique with [³H]-Thymidine and Bromodeoxyuridine
… Lightly labeled A+A' cells (identified as osteoprogenitor cells) remained in close approximation to the surface of the CBV (within 25 μm) and C+D cells (preosteoblasts) were located closer to bone-forming surfaces (~50 μm away from the CBV). The number of osteoblasts were increased up to 60 …
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The Use of Dynamic Fluid Flow Strategies for Bone Tissue Engineering Applications
… for bone tissue engineering involves seeding osteoprogenitor cells within a biomaterial scaffold then culturing this construct in a biodynamic bioreactor. The bioreactor imparts osteoinductive mechanical stimuli on the cells to stimulate the synthesis of an extracellular matrix rich in …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… these mice have increased bone marrow osteoprogenitors and CD8+ T-cells which support osteoblast differentiation. The animals were not protected from bone loss following OVX, but retained the hypersensitivity seen in the intact mice. Mesenchymal stem/progenitor cells (osteoprogenitors) …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… BMP/Wnt interactions during proliferation of osteoprogenitors, by focusing on Smad4, a central mediator of the greater TGF-beta/BMP pathway. Acute, tamoxifen-induced deletion of <italic>Smad4</italic> in otherwise normal osteoblasts in mice activates proliferation of predominantly post-mitotic …
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The Role of Bisphosphonates and Osteoblast Lineage Cells in Promoting Osteogenic and Angiogenic Processes Necessary for Bone Repair
… these studies, we determined that pre-existing osteoprogenitor (Osx+ lineage) cells but not more mature osteoblasts (Dmp1+ lineage) cells readily contribute to woven bone forming osteoblasts during fracture. Although depletion of the Osx+ and Dmp1+ cell lineages during stress fracture repair did …
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Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration
Long-term exposure to pharmacological doses of glucocorticoids has been associated with the development of osteopenia and avascular necrosis. Bone loss may be partially attributed to a steroid-induced decrease in the osteoblastic differentiation of multipotent progenitor cells found in the bone …