Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Osteolytic"”.
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CD166 modulates disease progression and osteolytic disease in multiple myeloma
… cells in the bone marrow (BM) and by multiple osteolytic lesions throughout the skeleton. We previously reported that CD166 is a functional molecule on normal hematopoietic stem cells (HSC) that plays a critical role in HSC homing and engraftment, suggesting that CD166 is involved in HSC …
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Bone-Specific Metabolism and Mechanism of Action of Curcuminoids in Blocking Osteolysis in Breast Cancer and Other Resorptive Bone Diseases
… age-related bone loss, rheumatoid arthritis, and osteolytic bone metastases, affect over 55 million Americans each year. Breast cancer bone metastases, the model of bone resorptive disorders to be used here, causes osteolysis through a “vicious cycle”, whereby osteoclasts release growth factors …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
… a novel therapeutic agent for the treatment of osteolytic bone disease. Co-culture or conditioned medium studies using human or mouse cancer cell lines were used to develop an in vitro model system of tumour cell – bone cell interactions. This showed that osteolytic tumour cells enhance …
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Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model
… that GW2580 and ABT-869 significantly decreased osteolytic lesions and tumor growth in MDA-MB-231 bone metastases. Also, GW2580 increased bone mass in normal C57BL/6 mice, validating the effect of this inhibitor on CSF-1R-expressing osteoclasts in vivo. Since IC87114 failed to reduce tumor growth …
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골경화성 골전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성
… change (84/88, 95%) with only 4 lesions showed osteolytic change on corresponding CT images. The most lesions on F-18 FDG PET/CT also demonstrated sclerotic change (20/23, 87%) with 3 osteolytic lesions. All metastatic lesions detected on bone scintigraphy and F-18 FDG PET/CT were found on F-18 …
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Identificazione di bersagli terapeutici e realizzazione di tecnologie innovative in oncologia ortopedica
… is a novel approach for the adjuvant therapy of osteolytic bone metastases. Doxorubicin (DXR) is widely used in chemotherapy, although its activity is restricted by dose-dependent cardiotoxicity and marrow toxicity. However, its efficacy can be improved when specific targeting at the tumor site …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΟΥ ΡΟΛΟΥ ΤΩΝ ΟΙΣΤΡΟΓΟΝΩΝ ΣΤΗΝ ΟΣΤΙΚΗ ΕΠΟΥΛΩΣΗ (ΚΑΤΑΓΜΑ ΚΑΤΩ ΓΝΑΘΟΥ). (ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ)
… THEIR KNOWN CONTRIBUTION TO THE RESTRAINT OF THE OSTEOLYTIC PROCESSWHICH OCCURS IN OSTEOPOROSIS. FRACTURES WERE EXPERIMENTALLY CAUSED TO THE ANGLE OF THE MANDIBLE OF 63 FEMALE WISTAR RATS. TWENTY ONE OF THE ANIMALS COMPOSED THE CONTROL GROUP. BENZOIC ESTRADIOL WAS ADMINISTERED INTRAMUSCULARY TO …
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Δυναμική ταξινόμηση των μορφών της νόσου του Paget των οστών και η θεραπευτική αντιμετώπισή τους
… of bone turnover or remodelling: that is, the osteolytic phase, the mixed phase, and the osteoblastic phase. Normal or diminished bone scan activity in the osteoblastic phase indicates diminished bone turnover which we distinguish as the osteosclerotic phase. Modelling states or bone …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
… dogs with osteoblastic OS compared to those with osteolytic OS. We investigated FGFR gene expression with reverse transcriptase polymerase chain reaction (RT-PCR) and FGF2 secretion via ELISA. The effects of FGF signaling attenuation on OS cell pro-tumorigenic properties were evaluated by …
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Three-Dimensional Analysis of the Development of Upper Arm Musculoskeletal Stress Markers in Late Adolescents and Young Adults of Archaic and Mississippian Populations of Tennessee
… seen were in scoring Robusticity rather than Osteolytic or Osteophytic Activity. In all instances, late adolescents in this study followed the general pattern set by the other age sets. The results of this study suggest that three-dimensional scans, at this point may not be optimal for MSM …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… p-smad2 to activate PTHrP expression and bone osteolytic effect. Taken together, we reveal a novel mechanism that 14-3-3ζ dictates the tumor suppressor or metastases promoter activities of TGF-β signaling pathway through switching p-smad2 binding partner from p53 to Gli2. The expected results …
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Autocrine prolactin signaling in breast cancer cells leads to metabolic changes and therapeutic opportunities for anti-tumour and anti-bone metastatic treatment
… women worldwide and is often associated with osteolytic bone metastasis, characterized by bone destruction. There is growing evidence for a role of autocrine prolactin (PRL) signalling in breast cancer progression, as well as for a role of prolactin in breast cancer-associated bone metastasis. …
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Reciprocal communication between cancer cell and tumor microenvironment promotes breast cancer metastasis
… is a key regulator involved in the formation of osteolytic niche, suggesting its potential as a novel biomarker and therapeutic target for breast cancer bone metastasis.
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“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
… cells. Since PTHrP enhances the growth and osteolytic potential of prostate cancer cells, it is important to control PTHrP expression in these cells. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) downregulates PTHrP expression in a variety of human cell types, including prostate cancer cells. …
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Aseptic loosening around total hip and knee arthroplasty is linked to plasma microRNA
… are detectable at the molecular level in osteolytic bone samples. This is the first study to our knowledge investigating the role of circulating miRNA in patients with aseptic loosening around hip and knee replacements. These findings help us understand the pathophysiology of osteolysis …
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Treatment response using CT-based rigidity analysis in an animal model of lytic musculoskeletal lesions subjected to systemic therapy
Cancer is a global epidemic; over 1.5 million new cancer diagnoses and greater than 600,000 deaths due to cancer are estimated to occur in the United States within the year 2015 alone. Approximately two-thirds of patients with bone metastases will experience pain, pathological fractures, spinal …