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Showing 1 to 10 of 10 for “"Osteoinductivity"”.
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The Assessment of Osteoinductivity of Human Allograft Demineralized Bone Matrix by <i>In Vivo</i> and <i>In Vitro</i> Assay Models
<p>The osteoinductive potential (osteoinductivity) is a very important aspect of demineralized bone matrix (DBM) as a biomaterial. This study is directed at establishing qualitative and quantitative assays of the osteoinductivity of human DBM. Further aspects of this study include an assessment of …
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The Quantitative Assessment of Osteoinductivity of Human Demineralized Bone Matrix and cDNA Array Analysis of Osteogenic Differentiation in Human Periosteal Cells
… <em>in vitro</em> assay. At the same time, the osteoinductivity of DBM was measured by histomorphometric analysis of new bone formation in an <em>in vivo</em> athymic mouse bioassay. DBM exhibiting high osteoinductivity in the nude mouse bioassay contained higher amounts of extractable BMP-4 …
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Osteoblast Response to Zirconia-Hybridized Pyrophosphate Stabilized Amorphous Calcium Phosphate
… (PLGA) scaffold could potentially increase the osteoinductivity of the scaffold and therefore promote osteogenesis when implanted in vivo. To determine the osteoinductivity of Zr-ACP, a MC3T3-E1 mouse calvarial-derived osteoprogenitor cell line was used to measure cell response to Zr-ACP. To …
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Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing
… Wnt pathway was activated by HA but the osteoinductivity of HA itself overridden the Wnt modulating capacity of Li+. Finally, a global gene expression profiling demonstrated that the controlled release of Li+ from PLGA activated the canonical Wnt signaling. In conclusion, the present …
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Elucidating Cause-Effect Relationships between Extracellular Matrix Signaling and Mesenchymal Stem Cell Differentiation
… on associated cell behavior. In terms of the osteoinductivity of select ECM components, the results showed that both FG and LN enhanced the osteogenic response of encapsulated MSC cells. In addition, the integrin-based interactions supported by these ECM components indicated that integrin ?2 …
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Surface Patterned Ceramics Via Breath Figures Method With Potential Application As Implant Coatings
… coatings due to the enhanced bioactivity and osteoinductivity of the ceramic. For this reason in the second part of this work we evaluated the potential bioactivity of surface porous silicon oxynitrides in terms of bioactive silicon ions release capability and effects of different porosity …
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Preclinical Evaluation of 3D Printed Biomaterials for Repairing Critical-Size Bone Defects
… evaluate mineral content, cytocompatibility, osteoinductivity, microstructure and biomechanical properties. <br>4- *In-vivo* testing of the local biological effect of candidate biomaterials following subcutaneous implantation in rats. <br>5- *In-vivo* evaluation of the biomaterials’ ability to …
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Bioactive Poly(Lactic-co-Glycolic Acid)-Calcium Phosphate Scaffolds for Bone Tissue Regeneration
… and biocompatibility, but they often lack osteoinductivity and are resistant to biodegradation. Conversely, amorphous calcium phosphate (ACP) is a mineral that solubilizes under aqueous conditions, releasing calcium and phosphate ions, which have been postulated to enhance osteoblast …
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Bone Marrow Stromal Cell Invasion and Bone Regeneration in Enzymatically-Degradable Osteoinductive Hydrogels
… enhance biocompatibility, biodegradability and osteoinductivity. These characteristics make the synthetic scaffold and ideal bone analog for bone reconstruction. This work will focus on the establishment of a multifunctional synthetic scaffold which are enzymatically degradable and …
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Evaluation of Non-functionalized Single Walled Carbon Nanotubes Composites for Bone Tissue Engineering
… bone repair because of their osteoconductivity, osteoinductivity and osteogenicity. Nevertheless, the application of autografts is limited because of donor availability and donor site morbidity. Allografts have the advantage that the tissues are readily available and can be easily applied, …