Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Osteogenic differentiation"”.
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Bionanoparticles as Viable Substrates to Promote Osteogenic Differentiation of Bone Marrow Stromal Cells
… role that the nano environment plays on their differentiation potential. This dissertation focuses on studying the effect of nanotopography on the promotion of osteogenic differentiation of BMSCs. The nanoptopographies were created by coating 2D substrates with turnip yellow mosaic virus (TYMV) …
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Osteogenic differentiation of human mesenchymal stem cells on thin film tyrosine derived polycarbonates
… of regenerative medicine because of the vast differentiation potential into various cell lines such as: osteoblasts, chondrocytes, adipocytes, and neurons. Osteogenic differentiation of human mesenchymal stem cells (hMSC) could be an important tool in the treatment of orthopedic deficiencies …
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The design and numerical analysis of a microfluidicssystem for osteogenic differentiation of mesenchymal stemcells.
… early periods of mes-enchymal stem cells during osteogenic differentiation. Where the glucose/lactate levelsare assesed, including the development of a characteristic profile of the metabolomicand lipidomic factors that could allude to key biomarkers which could be used to assessthe proposed …
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Effects of Mild Heating on the Osteogenic Differentiation of Human Mesenchymal Stem Cells during Inflammation
… of the mechanisms that induce stem cell differentiation into desired tissues or structures, and enhance the qualitative extent of stem cell proliferation and differentiation, all while mitigating the effects of inflammation. Studies have shown that temperature is strongly correlated with …
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Modulation of Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells through Signals in the Extracellular Microenvironment
… functional regeneration by modulating MSC differentiation are a promising alternative to the limitations and potential complications associated with current conventional therapies. In this work, signals present in the native microenvironment were utilized in fabricating …
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Adipose-Derived Stem Cell Osteogenic Differentiation: A Study of the Influence of Extracellular Matrix on the Differentiation Process
… these cells utilize to differentiate down the osteogenic pathway are still unclear. Specific differences exist between BMSC and ADSC osteogenesis; however more detailed analysis of how the two MSC types differ will be important for enhanced clinical relevance of ADSC. Chapter 1 of this work …
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The synergistic effect of pulsed electromagnetic fields and demineralized bone matrix on the osteogenic differentiation of mesenchymal stem cells
… that are osteoconductive, osteoinductive and osteogenic in order to achieve optimal bone healing. Furthermore, electrical stimulation technologies such as pulsed electromagnetic fields (PEMF) have been used to enhance the effectiveness of bone graft materials. PEMP has been shown to have a …
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An in vitro evaluation of tyrosine derived polyarylates and polycarbonate as polymeric scaffold for human mesenchymal stem cells osteogenic differentiation
… at minimum on the use of scaffolds that support differentiation. Therefore , this thesis details a study that systematically evaluated hMSC differentiation on materials that exhibit gradual range in surface properties as a first study for selecting materials as potential scaffolds. Polycarbonates …
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The Quantitative Assessment of Osteoinductivity of Human Demineralized Bone Matrix and cDNA Array Analysis of Osteogenic Differentiation in Human Periosteal Cells
… gene expression profiles during osteoblast differentiation in human periosteal cells.</p> <p>BMP-4 is one of the most osteoinductive factors and has been investigated for clinical applications. For this reason, BMP-4 was designated as the osteoinductive protein for use in the quantitative …
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Designing and constructing a prototype standalone bioreactor using 3D printing and finite element analysis : a tool to define osteogenic differentiation in a 3D mechanical environment
… make it operational for future studies involving osteogenic differentiation. This bioreactor system provides compression on scaffolds located in a chamber. It also has indirect perfusion, maintains a temperature of 37°C when running, and can maintain an optimal pH value of (7.2 to 7.6) for …
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The Notch Target Hes4 Promotes Osteosarcoma Tumor Growth and Metastasis By Inhibiting Osteogenic Differentiation, and Has Potential As A Prognostic Biomarker For Newly Diagnosed Patients With High Grade Osteosarcoma.
… of OS is caused by genetic disruptions of osteogenic differentiation, we sought to identify pathways that are involved in normal bone development and homeostasis. One such pathway is the Notch signaling pathway. We hypothesized that the Notch downstream target Hairy/Enhancer of Split 4 …
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Stimulations and modulations of chondrogenic differentiation of human embryonic stem cells
… systems, BMP2 was shown to induce chondrogenic differentiation and maturation/hypertrophy, of which distinct temporal pattern differences were observed. Further analysis suggested that BMP2 probably exerts a bipotent effect in inducing both chondrogenic and osteogenic differentiation, while …
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In Vitro Assessment of Bone and Cartilage Stimulating Peptides
… their effects on osteoprogenitor proliferation, osteogenic differentiation, cell culture mineralization and cell migration. BCSPs appeared to enhance the bone growth in the previous study using an animal model; however, the cellular and molecular mechanisms of BCSPs performance remain unclear. In …
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Bone Marrow Stromal Cell Invasion and Bone Regeneration in Enzymatically-Degradable Osteoinductive Hydrogels
… of conjugation of cell adhesion RGD peptide and osteogenic peptide KIPKA SSVPT ELSAI STLYL to a model biodegradable hydrogel on osteogenic differentiation of BMS cells and production of mineralized matrix was studied. RGD peptide was grafted to the hydrogel by adding acrylated RGD (Ac-GRGD) to …
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Investigation of adipose-derived mesenchymal stem cells interaction with electrospun demineralized bone matrix nanofiber scaffolds
… scaffolds. The ability to support osteoblastic differentiation of AD-MSCs for long-term (three weeks) in osteogenic differentiation media was also investigated. Both PCL scaffolds and DBM scaffolds seeded with no cells were used as control surfaces. The total protein content of viable AD-MSCs on …
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Comparative osteogenesis of equine mesenchymal stem cells isolated from bone marrow, adipose tissue, and synovium
… in this study were carried out to define the osteogenic potential of equine MSCs derived from synovium, bone marrow, and adipose tissue maintained under the same culture conditions. Equine MSCs were isolated from synovium [SYN], bone marrow [BM] and adipose tissue [AD], expanded in monolayer …
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Characterization of human adipose tissue-derived adult multipotent precursor cells
… and ascorbic acid to induce ADSCs towards the osteogenic lineage. In two- and three-dimensional induction studies, ADSC were able to express bone characteristics which were then confirmed in an in vivo model. This work progressed to the identification of candidate genes involved in …
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Characterization and comparison of cell frequency, growth, and multipotential differentiation of adult mesenchymal stromal cells derived from equine bone marrow and adipose tissue
… tissues, cell doubling characteristics and differentiation multipotential in culture based on histochemical staining and compositional analysis. Equine MSCs and ASCs from young adult horses were harvested and isolated from sternal bone marrow and supragluteal subcutaneous adipose tissue, …
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